Disclaimer: This protocol is for informational and educational purposes only. It is not medical advice. Always consult with a qualified physician before starting any new diet, supplement regimen, exercise program, or biohacking intervention, especially those involving pharmacological compounds or extreme fasting.
The "Titan Protocol": 3-Month Longevity & Peak Performance Optimization
This plan is designed to systematically upregulate longevity pathways (AMPK, mTOR inhibition, Autophagy) while maximizing physical output and cognitive throughput. It relies on a phased approach: Reset, Build, and Optimize.
Phase 0: The Data Infrastructure (Weeks -1 to 0)
Before starting, you must establish baselines. Without data, you are just guessing.
1. The Wearable Stack (Continuous Monitoring)
- Oura Ring or Ultrahuman Ring: For Sleep efficiency, HRV (Heart Rate Variability), and Readiness.
- Continuous Glucose Monitor (CGM) (e.g., Levels, Dexcom): Essential for understanding your personal metabolic response to food.
- Garmin/Coros Watch: For tracking training load (VO2 Max) and ECG.
2. The Bloodwork (Baseline)
Order a comprehensive panel (e.g., Function Health or Marek Health). Look for:
- Metabolic: HbA1c, Fasting Insulin, Homocysteine, Triglycerides/HDL ratio.
- Hormonal: Testosterone (Free/Total), DHEA-S, Cortisol (diurnal).
- Inflammatory: hs-CRP, Omega-3 Index, Vitamin D.
- Longevity: NAD+ levels (if available), Telomere length (optional).
Phase 1: The Metabolic Reset (Month 1)
Goal: Eliminate inflammation, improve mitochondrial efficiency, and establish metabolic flexibility (ability to burn fat and glucose equally well).
1. Dietary Protocol: Ketogenic-Cyclical
- Weeks 1-2 (Strict Keto): Target <20g net carbs/day. Focus on high healthy fats (avocado, EVOO, MCT), moderate protein (1.6g-2g per kg lean body mass), and low carbs.
- Weeks 3-4 (Targeted Ketogenic): Introduce carbohydrates only around the heaviest workout window (post-workout). 25-50g of glucose (dextrose or rice) to replenish glycogen without spiking insulin excessively.
- Elimination: Remove all seed oils (soybean, canola), processed sugars, and alcohol.
2. Fasting Regimen
- Daily: 16:8 (16 hours fasting, 8 hours eating). Stop eating by 8:00 PM.
- Weekly: One 24-hour fast (dinner to dinner) in Week 2 and Week 4 to boost autophagy.
3. Exercise: Zone 2 & Foundation
- Focus: Aerobic base building.
- Protocol: 3x/week Zone 2 Cardio (45-60 mins). Zone 2 is defined as "conversational pace"—you can speak in full sentences but feel slightly breathless. This builds mitochondrial density.
- Strength: 2x/week Full Body hypertrophy (3 sets of 10-12 reps, moderate weight).
- Steps: Minimum 8,000 steps daily.
4. Supplement Stack (Daily)
- Morning (Fastened):
- Creatine Monohydrate: 5g (Cognitive & muscle retention).
- Lion's Mane Mushroom: 500mg (NGF production for brain health).
- Spirulina/Chlorella: 5g (Heavy metal binding).
- With Food:
- Vitamin D3 + K2: 5,000 IU D3 / 100mcg K2.
- Omega-3 (High DHA): 2g (Brain health).
- Magnesium Glycinate: 400mg (Sleep/Muscle relaxation).
- Night:
- L-Theanine: 200mg (Relaxation).
- Apigenin: 50mg (GABA modulation).
Phase 2: Peak Performance & Hypertrophy (Month 2)
Goal: Maximize physical output, cognitive drive, and anabolic signaling. We introduce "hormetic stressors."
1. Dietary Protocol: Protein-Pacing & Nutrient Timing
- Macros: Increase protein to 1.8g-2.2g per kg LBM. Protein is the primary driver of longevity (sarcopenia prevention).
- Carb Cycling:
- Low Carb Days (Mon, Tue, Thu, Fri): <30g carbs.
- High Carb Days (Wed, Sat): 150-200g clean carbs (sweet potato, white rice) post-workout to spike mTOR for growth.
2. Fasting Regimen
- Daily: 14:10 (Shorter window to support higher training volume).
- Weekly: No 24-hour fasts. We need fuel for performance.
3. Exercise: VO2 Max & Strength
- VO2 Max: 1x/week. The "Norwegian 4x4" Protocol: Warm up, then 4 minutes of hard effort (90-95% max HR) followed by 3 minutes active rest. Repeat 4 times.
- Strength: 3x/week. Split (Push/Pull/Legs). Focus on heavy compound lifts (Deadlift, Squat, Bench) in the 5-8 rep range.
- Rucking: 1x/week (Weekend). 45-60 mins with weighted vest (10-20lbs). Low impact, high metabolic demand.
4. Supplement Stack (Additions)
- Pre-Workout:
- Citrulline Malate: 6-8g (Blood flow).
- Beta-Alanine: 3.2g (Buffer acid—causes tingles).
- Longevity/Cognitive:
- Spermidine: 1mg daily (Autophagy inducer).
- Urolithin A: 500mg (Mitophagy—mitochondrial recycling).
- Stress Resilience:
- Rhodiola Rosea: 300mg pre-workout or morning (Adaptogen).
5. Advanced Stress Resilience: HRV Training
- Use the Elite HRV or Oura app.
- Practice: 10 minutes of "Coherent Breathing" daily. Inhale for 5.5 seconds, Exhale for 5.5 seconds.
- Goal: Increase HRV baseline (parasympathetic tone).
Phase 3: Deep Cellular Repair & Cognitive Optimization (Month 3)
Goal: The "Deep Clean." Aggressively targeting senescent cells ("zombie cells") and DNA repair.
1. Dietary Protocol: The Fasting-Mimicking Diet (FMD)
- Weeks 1 & 3: Normal high-protein diet.
- Week 2 (The Deep Dive): 5-day ProLon Fasting Mimicking Diet or homemade version.
- Calories: ~1,100 Day 1, ~800 Days 2-5.
- Macros: High Fat (approx 11%), Low Protein (approx 9%), Low Carb (approx 44%).
- Result: Massive stem cell regeneration and lowered IGF-1.
- Week 4: Return to Ketogenic diet.
2. Fasting Regimen
- Daily: Back to 16:8 or 18:6 (Time Restricted Feeding).
- Circadian Fasting: Stop eating 3 hours before bed.
3. Exercise: Mobility & Blood Flow
- Focus: Recovery and vascular health.
- Protocol:
- Zone 2: 2x/week (30 mins).
- Strength: 2x/week (Maintenance, 2 sets of 15 reps, lighter weight).
- Nasal Breathing Only: Restrict breathing during all cardio to increase CO2 tolerance and nitric oxide production.
4. Supplement Stack (The "Senolytic" Phase)
- Note: These are powerful compounds. Cycle carefully.
- Quercetin: 500mg + Theaflavins: 300mg (Senolytics—induce death of zombie cells). Take for 3 days consecutively, then stop.
- Fisetin: 500mg (Alternate days during Week 2).
- NMN (Nicotinamide Mononucleotide): 500mg-1g daily (NAD+ precursor).
- PQQ (Pyrroloquinoline Quinone): 20mg (Mitochondrial biogenesis).
5. Cognitive Neurofeedback
- Tool: 20Hz Binaural Beats or an app like Muse for meditation.
- Protocol: 20 minutes of "Deep Work" immediately following a cold plunge (see below).
The Daily "Biohacker" Routine (Sample Day)
06:00 AM: Wake Up
- Action: No snooze. Get natural sunlight exposure in eyes immediately (sets circadian rhythm).
- Hydration: 500ml water with Sea Salt (sodium/potassium) and Lemon Juice.
06:30 AM: Movement & Cold
- Exercise: 30 min Zone 2 Cardio (Rucking or Cycling) OR 45 min Heavy Lifting (depending on phase).
- Cold Plunge: 3 minutes at 50°F (10°C) immediately post-exercise.
- Why: Dopamine reset (increases dopamine receptors by 250%), cold shock protein activation.
08:00 AM: Work Block 1 (Deep Work)
- Supplements: Creatine, Lion's Mane, Caffeine (200mg) + L-Theanine (200mg).
- Tech: Turn off notifications. Focus on highest cognitive load task.
12:00 PM: Break & Fuel
- Meal: Largest meal of the day. High protein, healthy fats, veggies.
- Post-Meal: 15 min walk (glucose disposal).
01:00 PM: Work Block 2
- Administrative tasks/Meetings.
04:00 PM: Physiological Reset
- Supplements: Magnesium, Omega-3.
- Activity: 5 minutes Box Breathing (Inhale 4s, Hold 4s, Exhale 4s, Hold 4s) or using a HeartMath device to synchronize HRV.
06:00 PM: Last Meal
- Diet: Lean protein and fibrous vegetables. Minimal carbs to prevent glucose spike before sleep.
08:00 PM: Digital Sunset
- Action: Turn off overhead lights. Use blue-light blocking glasses.
- Environment: Keep room cool (65°F-68°F).
09:30 PM: Sleep Hygiene
- Supplements: Apigenin, Glycine (3g), or low-dose Melatonin (0.5mg) if needed.
- Action: Read fiction (no screens). 10:00 PM Sleep target.
Glossary of Advanced Concepts
- Hormesis: The biological phenomenon where a beneficial effect results from the exposure to low doses of an agent that is otherwise toxic or lethal when given at higher doses (e.g., Exercise, Heat Sauna, Cold Plunge, Fasting).
- Senolytics: A class of drugs that selectively induce death of senescent cells (old cells that stop dividing but don't die, secreting inflammatory factors).
- Mitophagy: The selective degradation of mitochondria by autophagy. It is the cellular cleanup of "bad" mitochondria.
- VO2 Max: The maximum amount of oxygen your body can utilize during exercise. It is the single strongest predictor of all-cause mortality.
Expected Outcomes
- Month 1: Weight loss (mostly water), mental clarity stabilization, improved sleep score.
- Month 2: Increased muscle definition, higher VO2 max, elevated libido/energy.
- Month 3: Deep sense of well-being, improved biomarkers (HbA1c, fasting insulin), enhanced cognitive resilience.
Final Note: Biohacking is a game of inches. Track everything. If your HRV drops for 3 consecutive days, back off the training and increase sleep. The data drives the decisions.