Absolutely—great goal.
Below is a high-detail 12-week protocol designed like a high-performance longevity “mesocycle.”
I’ll keep it practical, measurable, and advanced—but still safe.
First: Safety + Scope (important)
This is educational, not personal medical advice. A plan this aggressive should be run with a physician, especially if you have any condition or take meds (glucose/BP/thyroid/anticoagulants/psychiatric meds, etc.).
Do not do prolonged fasting, ketosis, cold/heat stress, or supplements blindly if pregnant, underweight, history of ED, arrhythmia, seizure disorder, chronic kidney/liver disease, or uncontrolled endocrine/cardiovascular issues.
0) Week 0: Baseline Setup (before starting)
A) Clinical + lab baseline
Ask your clinician for:
- CBC, CMP, eGFR, AST/ALT
- Fasting glucose, fasting insulin, HbA1c
- Lipids: ApoB, LDL-C, HDL-C, TG, Lp(a)
- hs-CRP, homocysteine
- TSH, free T4, free T3
- Ferritin, B12, folate, vitamin D (25-OH)
- Omega-3 index (if available)
- Uric acid
- Optional (performance): total/free testosterone or estradiol, SHBG, IGF-1 (context-dependent)
B) Performance baseline
- DEXA (body comp + bone density)
- VO2max test (lab or wearable estimate baseline)
- Grip strength
- 5-rep max on key lifts (or estimated 1RM)
- Resting HR, HRV (7-day average)
- Cognitive baseline: reaction time + working memory app (e.g., Quantified Mind/Cambridge Brain Sciences)
C) Devices
- Wearable: Oura/WHOOP/Garmin (sleep, HRV, RHR, recovery)
- CGM: 2–4 weeks at start (then periodic)
- Optional: blood ketone meter (during keto phases), home BP cuff
1) The 12-Week Architecture
- Phase 1 (Weeks 1–4): Foundation + metabolic reset
- Phase 2 (Weeks 5–8): Metabolic flexibility + capacity build
- Phase 3 (Weeks 9–12): Performance optimization + consolidation
Deload at weeks 4 and 8. Re-test in week 12.
2) Nutrition Protocol (advanced but sustainable)
Global rules (all 12 weeks)
- Protein: 1.6–2.2 g/kg/day
- Fiber: 30–45 g/day
- Hydration: 30–40 ml/kg/day + electrolytes
- Alcohol: ideally 0 (or max 1–2/wk)
- Meal timing: finish last meal 3+ hours before bed
Phase 1 (Weeks 1–4): “Clean ketogenic reset”
- Carbs: 30–60 g net/day
- Protein: 1.8–2.2 g/kg
- Fats: remainder of calories (mostly EVOO, avocado, nuts, eggs, fatty fish)
- Feeding window: 14:10, progress to 16:8 if energy/sleep stable
- Goal: flatten glucose variability, improve satiety and mitochondrial efficiency
CGM targets:
- Fasting glucose: ~75–90 mg/dL
- Most postprandials <140 mg/dL
- 24h glucose variability low
Phase 2 (Weeks 5–8): “Cyclical keto + performance carbs”
- 5 low-carb days + 2 higher-carb refeed days aligned to hardest training
- Low-carb days: 50–80 g net carbs
- Refeed days: 150–250 g carbs (mostly whole-food starch: potatoes, rice, oats, fruit)
- Continue 16:8 most days
- Optional: 1 x 24h fast/week (non-HIIT day), only if sleep/recovery unaffected
Phase 3 (Weeks 9–12): “Metabolic flexibility + longevity maintenance”
- Targeted carbs around training:
- 30–60 g pre/post high intensity or heavy lifting
- Non-training days lower carb (50–100 g net), training days moderate (120–220 g)
- Optional: 36h fast once every 2–3 weeks if already well adapted (skip if sleep, mood, or training drops)
3) Supplement Stack (with doses, timing, cycling)
Use as a clinician-reviewed template, not a mandatory list.
Foundation stack (daily)
- Creatine monohydrate: 3–5 g/day (any time)
- Omega-3 (EPA+DHA): 1.5–2.5 g/day with meals
- Magnesium glycinate/taurate: 200–400 mg elemental at night
- Vitamin D3: usually 1000–2000 IU/day (adjust by labs)
- K2 MK-7 90–180 mcg/day if appropriate
- Glycine: 3 g 30–60 min pre-bed (sleep quality support)
Performance/cognitive add-ons (cycle)
- Caffeine + L-theanine (focus days):
- caffeine 50–150 mg + L-theanine 100–200 mg
- cycle: 5 days on / 2 off
- Rhodiola rosea: 200–400 mg AM (std. extract)
- cycle: 6 weeks on / 2 weeks off
- Citicoline (CDP-choline): 250–500 mg AM on cognitively heavy days
- Curcumin phytosome: 500 mg 1–2x/day with food (if inflammation/joint load high)
- Electrolytes on low-carb/fasting days: sodium/potassium/magnesium as needed
Sleep rescue (as-needed, not nightly dependence)
- Melatonin: 0.3–1 mg, occasional use for schedule reset
Avoid random stacking of many nootropics at once. Add one variable every 7–10 days.
4) Training Plan (strength + HIIT + zone 2 + recovery)
Weekly template (most weeks)
- Mon: Lower-body strength + 15 min Zone 2 cooldown
- Tue: Upper-body strength + mobility
- Wed: Zone 2 (45–60 min) + core
- Thu: Full-body strength (power emphasis)
- Fri: HIIT (VO2 block) + easy walk
- Sat: Long Zone 2 (60–90 min) or ruck/hike
- Sun: Recovery (mobility, breathwork, optional light yoga)
Strength details
- 3 sessions/week
- Main lifts: squat/hinge/push/pull/carry
- 3–5 sets of 4–8 reps for compound lifts
- Progression: +1 rep or +2.5–5% load weekly if recovery good
- Deload weeks 4 and 8: reduce volume by ~40–50%
HIIT protocol
- 1–2 sessions/week max
- Example: 4x4 min hard (90–95% max HR) with 3 min easy between
- Do not place HIIT the day after poor sleep or low HRV streak
Zone 2 target
- 2–3 sessions/week
- 45–90 min/session
- Nasal-breathing possible, conversational pace
- Goal: aerobic base and mitochondrial density
5) Recovery + Stress Resilience Stack
- HRV resonance breathing:
- 10 min, 1–2x/day at ~5.5–6 breaths/min
- NSDR/Yoga Nidra: 10–20 min afternoon (especially on high-cognitive days)
- Sauna: 3–4x/week, 15–25 min (80–90°C), rehydrate + electrolytes
- Cold exposure: 2–3x/week, 2–5 min cool/cold water (not immediately post-lifting if hypertrophy is priority)
- Neurofeedback concept:
- 2–3 sessions/week with alpha-theta/SMR training (clinic or validated platform)
- track objective outcomes (sleep latency, HRV, reaction time)
6) Sleep Protocol (non-negotiable longevity lever)
- Fixed wake time (±30 min daily)
- Morning outdoor light within 30 min of waking
- Caffeine cutoff: 8–10 hours before bed
- Bedroom: dark, cool, quiet
- Pre-sleep routine (30–45 min): low light, no intense cognitive load
- Track: sleep efficiency, deep sleep trends, resting HR/HRV
7) Data-Driven Decision Rules (biohacker control loop)
Use a weekly review dashboard:
- If HRV ↓ >15% + RHR ↑ >7 bpm for 2+ days → reduce training intensity 30–50%, prioritize sleep/recovery
- If CGM shows frequent >160 mg/dL spikes → reduce refined carbs, add post-meal walks, increase protein/fiber first
- If sleep <6.5 h for 2 nights → no HIIT; keep Zone 2 only
- If strength stalls 2+ weeks → increase calories/protein or reduce fasting frequency
- If mood/libido/cognition declines → pull back fasting and stimulant load first
8) 12-Week Milestones
- Week 0: baseline labs + device setup
- Week 4: deload + mini review (sleep, HRV, CGM trends, training load)
- Week 8: deload + adjust macros/fasting by objective recovery
- Week 12: re-test labs/performance, compare to baseline, lock long-term plan
If you want, I can turn this into a day-by-day calendar (exact meals, exact workout sessions, supplement timing by clock time) tailored to your age, sex, body weight, and whether your top priority is max lifespan vs peak performance.