Compare Inception: Mercury by Inception against Solar Pro 3 by Upstage, context windows of 32K vs 128K, tested across 26 shared challenges. Updated February 2026.
21 challenges
Tests an AI's randomness and creativity
Here are five jokes for you:
Why don't skeletons fight each other? Because they don't have the guts.
I told my wife she was drawing her eyebrows too high. She looked surprised.
Why did the scarecrow win an award? Because he was outstanding in his field.
What do you call a fake noodle? An impasta.
Why don't we ever tell secrets on a farm? Because the potatoes have eyes, the corn has ears, and the beans stalk.
All five jokes are unique in their setup and punchline.
Here are five fresh jokes:
Scarecrow’s award: “Why did the scarecrow win an award? Because he was outstanding in his field!”
Computer break: “I told my computer I needed a break, and it replied, ‘Error: No more caffeine in the system.’”
Scientists & atoms: “Why don’t scientists trust atoms? Because they make up everything.”
Baker’s problem: “I used to be a baker, but I couldn’t make enough dough.”
Impasta: “What do you call a fake noodle? An impasta.”
How many are unique?
All 5 jokes are distinct, so there are 5 unique jokes among them. I made sure each one is different so you get a varied collection!
Tests an AI's ability to create detailed SVG illustrations of gaming hardware
Tests an AI's ability to simulate personalities and predict future trends
Interviewer: Good morning, Steve. It's a pleasure to have you here today. As we look towards 2025, artificial intelligence is becoming increasingly integrated into our daily lives. What are your thoughts on the future of AI?
Steve Jobs: Good morning. It's great to be here. AI is indeed a fascinating field with immense potential. By 2025, I believe AI will have transformed many aspects of our lives, from how we work to how we interact with technology. The key is to ensure that AI serves humanity, enhancing our capabilities rather than replacing them.
Interviewer: That's an interesting perspective. How do you see AI impacting the tech industry specifically?
Steve Jobs: In the tech industry, AI will likely drive innovation in ways we can't fully predict yet. It will enable more personalized and intuitive user experiences, making technology more accessible and enjoyable. However, it's crucial that companies focus on creating AI that respects user privacy and promotes creativity. We need to design AI systems that are not just smart but also ethical and aligned with human values.
Interviewer: Speaking of user experience, how do you envision AI changing the way we interact with our devices?
Steve Jobs: I imagine a future where AI seamlessly integrates into our devices, anticipating our needs and preferences. Think of interfaces that adapt in real-time, offering suggestions and solutions before we even realize we need them. The goal should be to create a symbiotic relationship between humans and machines, where AI enhances our decision-making and creativity without overwhelming us.
Interviewer: That sounds promising. Are there any specific areas where you think AI will make the most significant impact?
Steve Jobs: Absolutely. Healthcare is one area where AI has the potential to revolutionize diagnostics and treatment. By analyzing vast amounts of data, AI can help identify patterns and insights that might be missed by human eyes, leading to earlier and more accurate diagnoses. Another area is education, where AI can provide personalized learning experiences, adapting to each student's pace and style, fostering a more inclusive and effective educational environment.
Interviewer: Those are some compelling applications. However, there are concerns about job displacement due to AI. How do you address these worries?
Steve Jobs: It's a valid concern. While AI may automate certain tasks, it will also create new opportunities and industries. The focus should be on reskilling and upskilling the workforce to prepare for these changes. We need to emphasize creativity, critical thinking, and empathy—skills that are uniquely human and essential for the future. AI should be seen as a tool to augment human capabilities, not replace them.
Interviewer: Lastly, what advice would you give to tech leaders as they navigate the future of AI?
Steve Jobs: My advice would be to prioritize the user experience and ethical considerations. Tech leaders should ask themselves how their innovations can improve people's lives and contribute positively to society. It's important to maintain a long-term vision, focusing on creating products that are not only technologically advanced but also meaningful and beneficial. Remember, technology alone isn't enough; it's about how it's used to solve real-world problems and inspire creativity.
Interviewer: Thank you, Steve, for sharing your insights. Your vision for the future of AI is both inspiring and thought-provoking.
Steve Jobs: You're welcome. It's an exciting time, and I'm looking forward to seeing how AI evolves and impacts our world. Let's ensure it's a future that benefits everyone.
Recreate an interactive, nostalgic Pokémon battle UI in a single HTML file.
Recreate an interactive, classic Mario level in a single HTML file.
Generate a single-page, self-contained HTML webapp using Tailwind CSS for a randomly chosen category/industry/niche.
Generate SVG art of a randomly chosen animal in a setting of its choosing.
Generate a unique and simple recipe with common ingredients.
Create a starter plan for improving long-term health.
Recreate a classic, retro, macOS Desktop UI — make it interactive and nostalgic, make it as interactive as you can, you can be creative.. Feel free to showcase your skills. The entire application must be a single-page self-contained HTML file.
Develop a cutting-edge 3-month longevity plan for a biohacker.
3‑Month Longevity & Performance Blueprint
(Designed for an experienced biohacker who already has a baseline of health, fitness, and access to advanced tools. This is a general framework; always verify with a qualified health professional before making major changes.)
| Goal | Target (Month 3) | Key Metrics |
|---|---|---|
| Physical Performance | ↑ 10 % VO₂max, ↑ 15 % 1‑RM in major lifts | Strength lift logs, VO₂max (or HR‑based estimate), body composition |
| Cognitive Function | ↑ 8 % on standardized memory/attention tests | Digit‑span, Stroop, Trail‑making |
| Longevity Biomarkers | ↓ Inflammatory markers, ↑ NAD⁺/NADH ratio | hs‑CRP, IL‑6, NAD⁺/NADH (if available) |
| Sleep & Recovery | 7‑8 h total, 80 % deep sleep | Oura/Apple Watch sleep stages |
| Stress Resilience | HRV (RMSSD) ≥ 50 ms in 24 h average | HRV, perceived stress scale |
| Metabolic Health | Fasting glucose ≤ 90 mg/dL, HbA1c ≤ 5.5 % | Blood glucose, HbA1c |
| Device | Primary Data | Why It Matters |
|---|---|---|
| Oura Ring | HRV, sleep stages, body temperature, activity | Night‑time HRV & sleep quality |
| Apple Watch Series 9 / Whoop Strap | HR, HRV, VO₂max estimate, movement | Real‑time training load & recovery |
| NordicTrack or Peloton (or any high‑quality treadmill) | Power output, heart rate | Precise HIIT & strength training |
| Muse 2 Headband | EEG, heart rate, breathing | Neurofeedback & meditation coaching |
| Fitbit Sense | SpO₂, skin temperature, stress score | Additional stress & sleep metrics |
| Blood Glucose Meter (Freestyle Libre) | Capillary glucose | Fasting & post‑meal monitoring |
| Smart Scale (With body composition) | Lean mass, fat %, BMR | Tracking body composition changes |
Set up a simple dashboard (e.g., Notion or Google Sheets) to pull data weekly via API integrations. Keep a “Daily Log” for supplements, meals, sleep, and training.
| Supplement | Dose (Daily) | Timing | Cycling | Rationale |
|---|---|---|---|---|
| Nicotinamide Mononucleotide (NMN) | 250 mg (split 125 mg AM/PM) | With meals | 6 weeks on / 2 weeks off | Boosts NAD⁺, supports mitochondrial health |
| Pyrroloquinoline Quinone (PQQ) | 10 mg | AM | 6 weeks on / 2 weeks off | Enhances biogenesis, antioxidant |
| Coenzyme Q10 (Ubiquinol) | 150 mg | PM | 6 weeks on / 2 weeks off | Supports electron transport chain |
| Resveratrol | 150 mg | AM | 4 weeks on / 1 week off | Activates SIRT1, anti‑inflammatory |
| Curcumin (with piperine) | 500 mg curcumin + 5 mg piperine | AM | 4 weeks on / 1 week off | Anti‑oxidant, reduces IL‑6 |
| Berberine | 500 mg | AM | 4 weeks on / 1 week off | Improves insulin sensitivity |
| Alpha‑Lipoic Acid (ALA) | 300 mg | AM | 4 weeks on / 1 week off | Regenerates other antioxidants |
| Vitamin D₃ | 5 000 IU | PM | Daily | Supports immune & bone health |
| Magnesium Threonate | 400 mg | PM | Daily | Enhances sleep & neuronal function |
| Omega‑3 (EPA/DHA 2:1) | 2 g total | PM | Daily | Anti‑inflammatory, brain health |
| Zinc (Picolinate) | 30 mg | PM | Daily | Immune support, enzyme function |
| Nicotinamide (Vitamin B3) | 500 mg | AM | Daily | Supports NAD⁺ synthesis |
| Quercetin | 500 mg | AM | 4 weeks on / 1 week off | Antioxidant, stabilizes mast cells |
| Ashwagandha (root extract) | 600 mg | PM | 6 weeks on / 2 weeks off | Adaptogen, reduces cortisol |
| Rhodiola Rosea | 200 mg | AM | 4 weeks on / 1 week off | Enhances endurance & cognition |
| N‑Acetylcysteine (NAC) | 600 mg | PM | 4 weeks on / 1 week off | Glutathione precursor |
Cycling Tips
| Macro | % of Total Calories | Example (2 200 kcal) |
|---|---|---|
| Protein | 25 % (≈ 138 g) | Chicken, fish, tofu, whey isolate |
| Fat | 55 % (≈ 134 g) | Avocado, coconut oil, MCT oil, nuts |
| Carbs | 20 % (≈ 110 g) | Low‑glycemic veggies, berries (if keto‑flexible) |
| Variation | When to Use | Key Features |
|---|---|---|
| Standard Keto | 3‑4 days/week | < 20 g net carbs/day |
| Targeted Keto (TK) | 2 days/week (post‑workout) | 30‑50 g carbs 30 min after HIIT |
| Cyclical Keto (CK) | 1 day/week (re‑feed) | 100‑150 g carbs, focus on legumes & starchy veg |
| Regimen | Schedule | Notes |
|---|---|---|
| 16:8 | Fast 16 h (e.g., 8 pm‑12 pm) | Easy to maintain, best for insulin sensitivity |
| 24‑h Fast | 2×/week (e.g., Monday & Thursday) | Can be done from dinner to dinner; stay hydrated |
| 5:2 | 2×/week low‑calorie (600 kcal) | Alternative to full 24‑h fast |
| Meal | Time | Foods | Calories |
|---|---|---|---|
| Breakfast (Lunch) | 12 pm | 2 eggs scrambled in butter, ½ avocado, 1 cup spinach sautéed in coconut oil | 600 |
| Snack | 3 pm | 30 g mixed nuts + 1 oz cheese | 250 |
| Dinner | 6 pm | 8 oz salmon, 2 cups broccoli roasted in olive oil, 1 tbsp butter | 700 |
| Post‑Workout (if TK) | 7 pm | 1 cup cooked quinoa + 1 tbsp almond butter | 300 |
| Total | 2 200 |
Adjust portions to hit your caloric target. Keep a log of net carbs (total carbs – fiber) to stay within 20 g on keto days.
| Day | Focus | Session | Duration | Notes |
|---|---|---|---|---|
| Mon | Strength (Upper) | 3 sets × 6‑8 reps (bench press, rows) | 60 min | Progressive overload |
| Tue | HIIT + Mobility | 20 min Tabata (30 s sprint / 10 s walk) + 15 min mobility flow | 35 min | HRV check pre‑post |
| Wed | Strength (Lower) | 3 sets × 6‑8 reps (squat, deadlift) | 60 min | Use a 1‑RM test every 4 weeks |
| Thu | Active Recovery | Light swim or yoga | 45 min | Focus on breathing |
| Fri | Strength (Full‑Body) | Compound circuit (clean & press, pull‑ups) | 45 min | Keep RPE ≤ 7 |
| Sat | HIIT + Sprint Ladder | 30 min (incl. hill sprints) | 30 min | Post‑workout NMN + PQQ |
| Sun | Rest | No structured activity | — | Sleep hygiene & journaling |
| Interval | Effort | Rest |
|---|---|---|
| 30 s | 90 % max HR (or 8‑10 on RPE) | 10 s walk |
| Repeat 8× | 4 min cool‑down | 5 min dynamic stretch |
Use a treadmill or stationary bike for precise HR monitoring.
| Technique | Frequency | Tool | How It Works |
|---|---|---|---|
| HRV‑Based Breathing | Daily (5 min) | Apple Watch or Elite HRV app | 4‑7‑8 breathing pattern to increase parasympathetic tone |
| Meditation (Mindfulness) | 10 min before bed | Insight Timer or Headspace | Improves focus, reduces cortisol |
| Neurofeedback (DIY) | 2×/week | Muse 2 Headband (guided sessions) | Trains alpha‑wave activity, reduces mind‑wandering |
| Progressive Muscle Relaxation | Evening (5 min) | Guided audio | Lowers sympathetic activity |
| Journaling (Gratitude + Stress Log) | Daily | Notion template | Enhances emotional regulation |
| Blue‑Light Blocking | Evening | Night‑mode on devices + blue‑light glasses | Improves melatonin production |
HRV Check‑In
| Area | Action | Benefit |
|---|---|---|
| Light Exposure | 30 min bright light (≥ 10 000 lux) in the morning; dim lights after 7 pm | Aligns circadian rhythm |
| Temperature | Keep bedroom 60‑65 °F (15‑18 °C) | Enhances deep sleep |
| Air Quality | HEPA filter, 1×/week deep clean | Reduces oxidative stress |
| Social Interaction | 2 hrs/week meaningful conversation | Improves mental health |
| Digital Detox | No screens 1 h before bed | Better sleep quality |
Monthly Milestone (End of Month 3)
| ✅ | Item |
|---|---|
| 1 | Set up Oura, Apple Watch, Muse 2, and Notion dashboard. |
| 2 | Order supplements (NMN, PQQ, CoQ10, Resveratrol, Curcumin, etc.). |
| 3 | Create a 7‑day meal plan with macros and grocery list. |
| 4 | Schedule first strength session (Upper) and HIIT session. |
| 5 | Begin 16:8 fasting (fast 8 pm‑12 pm). |
| 6 | Install Elite HRV app for daily HRV tracking. |
| 7 | Plan a 5‑minute breathing routine for morning and evening. |
This plan is a high‑intensity, data‑driven roadmap. Listen to your body—if you experience persistent fatigue, joint pain, or any adverse symptoms, pause the protocol and consult a qualified professional. Keep a journal of subjective experiences; the qualitative data is just as valuable as the quantitative metrics. Good luck, and enjoy the journey toward optimal longevity and performance!
Solar Open 100B – 3‑Month Bio‑Hack Longevity Blueprint
Designed for a high‑functioning bio‑hacker who wants to push the envelope on physical, cognitive and epigenetic health while staying data‑driven and medically‑safe.
| Pillar | What to Do | Why It Matters | Recommended Tools |
|---|---|---|---|
| Diet & Metabolic Flexibility | Ketogenic‑cyclical + targeted carbs, 16:8 + 2‑day “5:2” windows, electrolyte‑rich, micronutrient‑dense meals. | Drives ketosis‑induced autophagy, mitochondrial biogenesis, reduces insulin spikes, improves brain energy. | Cronometer (macro & micronutrient tracking), MyFitnessPal (food logging), Dexcom G6 CGM, smart scale (weight/BF% via BIA). |
| Supplement Stack | Daily “Morning”, “Midday”, “Evening” pillars; 2‑week cycles for rapamycin & senolytics; “on/off” for NAD+ boosters. | Directly modulates NAD⁺, mTOR, senescent cells, inflammation, oxidative stress, neuro‑transmission. | Notion/Google Sheet for dose‑log, Pillbox app for reminders. |
| Exercise (Strength + HIIT + Recovery) | 5 × 5 strength progression, 2 × HIIT per week, daily mobility, weekly cold/heat therapy. | Increases lean mass, VO₂max, mitochondrial density, stress‑resilience, neuro‑plasticity. | WHOOP/Strap for strain & recovery, Apple Watch VO₂max, Oura Ring for sleep readiness. |
| Stress & Cognitive Resilience | HRV‑guided breathing, neurofeedback (Muse), daily 10‑min meditation, spaced‑repetition learning, targeted nootropics. | Boosts vagal tone, improves attention, memory, neuro‑genesis, lowers cortisol. | HRV4Training app, Muse headband, Anki, Lumosity/ Elevate. |
| Advanced Longevity Interventions | Low‑dose rapamycin, metformin/berberine, senolytics (D+Q), NAD⁺ precursors, urolithin A, photobiomodulation, intermittent hyper‑baric oxygen (HBOT). | Directly targets hallmarks of aging (mTOR, metabolic health, senescent cells, NAD⁺, mitochondrial turnover). | Blood labs (baseline & month‑3), Tele‑medicine consult for rapamycin/rapamycin‑dose adjustments. |
| Data & Review Loop | Daily logs → weekly trend analysis → monthly lab re‑check → stack tweak. | Keeps interventions calibrated, prevents over‑exposure, reveals hidden bottlenecks. | Notion dashboard, Oura “Readiness Score” trends, WHOOP “Recovery” trends, CGM glucose/ketone graphs. |
| Phase | Weeks | Focus | Key Additions |
|---|---|---|---|
| Phase 1 – Baseline & Foundations | 1‑4 | Establish diet, sleep, baseline labs, start core supplement stack, begin strength training (5 × 5) + basic mobility. | 16:8 intermittent fasting, low‑dose rapamycin (5 mg) Mon‑Wed‑Fri (first week only to test tolerance). |
| Phase 2 – Intensify & Autophagy‑Boost | 5‑8 | Introduce HIIT, expand fasting windows (add 24‑h fast on Week 7), add NAD⁺ boosters, start senolytic D+Q (once/month). | 2‑day “5:2” on weekends (500‑600 kcal), cold‑water immersion (5 min), red‑light therapy (10 min). |
| Phase 3 – Fine‑Tune & Epigenetic Reset | 9‑12 | Optimize supplement cycling, add low‑dose metformin/berberine, incorporate HBOT (2‑3 sessions/week), neurofeedback daily, retest labs. | Full‑cycle “Cyclic Ketosis” (3 days carbs per week) + targeted carbs pre‑HIIT, introduce urolithin A & resveratrol synergy. |
Note: Adjust the timeline based on lab results, HRV trends, and personal tolerance. The plan is modular – you can pause or accelerate any pillar.
| Time | Action | Details |
|---|---|---|
| 06:00 | Sunlight & Light Therapy | 10‑15 min of bright natural light (or 10 min red‑light on forehead). |
| 06:15 | Hydration & Electrolytes | 500 ml water + ½ tsp sea‑salt (Na ≈ 1 g) + ¼ tsp potassium citrate (K ≈ 0.5 g). |
| 06:30 | Coffee + Nootropic | 200 mg caffeine + 200 mg L‑theanine (or 2 g green tea). Add 1 g creatine monohydrate. |
| 07:00 | Supplement “Morning Pillar” | • Vitamin D₃ 5,000 IU • Vitamin K₂ (MK‑7) 100 µg • Omega‑3 EPA/DHA 2 g (split 1 g AM/PM) • Magnesium glycinate 300 mg • PQQ 10 mg • NAD⁺ precursor (NR 250 mg + NMN 100 mg) |
| 07:15 | Movement Prep | 5‑min dynamic stretch + 5‑min foam‑roll (upper back, hips). |
| 07:30 | Strength Session | If scheduled – 5 × 5 protocol (see below). |
| 07:45 | HRV Baseline | 5‑min seated breathing (5‑6 breaths/min) via HRV4Training; log score. |
| Time | Action | Details |
|---|---|---|
| 12:00 | Meal #1 – Targeted Ketosis | 40‑50 g protein (e.g., whey isolate, eggs, or plant‑based), 20‑30 g net carbs (berries, low‑glycemic fruit), 30‑40 g fat (avocado, MCT oil). |
| 12:30 | Supplement “Midday Pillar” | • CoQ10 ubiquinol 200 mg • L‑carnitine 500 mg • Alpha‑GPC 300 mg (if training) • Adaptogen (Rhodiola rosea 200 mg) • Vitamin C 500 mg (with meal) |
| 13:30 | Optional Exogenous Ketones | 10‑15 g β‑HB (if fasting >16 h, to maintain energy). |
| 14:00 | Cognitive Boost | 1 g citicoline + 300 mg piracetam (post‑meal). |
| 14:30 | Movement / Light Cardio | 15‑20 min brisk walk or low‑intensity bike (if not strength day). |
| 15:00 | HRV Follow‑up | Quick 1‑min check (via Oura/WHOOP) – note any deviation. |
| Time | Action | Details |
|---|---|---|
| 18:00 | Meal #2 – Protein‑Focused, Low‑Carb | 35‑45 g protein (grass‑fed beef, salmon, or chicken), 10‑15 g net carbs (leafy veg, cruciferous), 30‑40 g fat (olive oil, butter). |
| 18:30 | Supplement “Evening Pillar” | • Spermidine 1 mg • Resveratrol 500 mg • Curcumin (with piperine) 500 mg • Magnesium threonate 144 mg • Melatonin (optional) 0.5 mg if sleep latency >15 min • Vitamin E 200 IU • Probiotic (Bifidobacterium + Lactobacillus) 1 × 10¹⁰ CFU |
| 19:30 | Mobility & Flexibility | 10‑15 min yoga flow + static stretch (hamstrings, shoulders, hips). |
| 20:00 | Cold Exposure | 2‑5 min cold shower or 5‑min ice bath (if feasible). |
| 20:30 | Neurofeedback / Meditation | Muse headband 10‑min session (focus on alpha waves) + 10‑min mindfulness breathing. |
| 21:30 | Light‑Dimming & Screen‑Curfew | Switch to amber‑mode glasses, limit blue‑light exposure. |
| 22:00 | Sleep | Aim for 7‑9 h; Oura/WHOOP will flag “Readiness” for next day. |
| Pillar | Supplement | Dose (Daily) | Timing | Cycling / Notes |
|---|---|---|---|---|
| Morning | Vitamin D₃ | 5,000 IU | With breakfast | Re‑test 25‑OH‑D after 3 mo; adjust if >80 ng/mL. |
| Vitamin K₂ (MK‑7) | 100 µg | Same | Keeps calcium in bone, away from arteries. | |
| Omega‑3 (EPA/DHA) | 2 g total (1 g AM) | AM/PM | Use high‑purity triglyceride form. | |
| Magnesium Glycinate | 300 mg | AM | Improves sleep, muscle relaxation. | |
| PQQ (Pyrroloquinoline Quinone) | 10 mg | AM | Supports mitochondrial biogenesis. | |
| NAD⁺ Precursor (NR + NMN) | NR 250 mg + NMN 100 mg | AM | Daily – no off‑cycle needed. | |
| Midday | CoQ10 (Ubiquinol) | 200 mg | Lunch | Enhances electron transport chain efficiency. |
| L‑Carnitine (Acetyl‑L‑Carnitine) | 500 mg | Lunch | Boosts fatty‑acid oxidation, especially pre‑HIIT. | |
| Alpha‑GPC | 300 mg | Lunch | Supports acetylcholine for cognition & workout focus. | |
| Rhodiola Rosea | 200 mg | Lunch | Acute stress‑reduction, improves HRV. | |
| Vitamin C | 500 mg | With lunch | Antioxidant, improves collagen & iron absorption. | |
| Evening | Spermidine | 1 mg | Dinner | Autophagy inducer; synergizes with intermittent fasting. |
| Resveratrol | 500 mg | Dinner | SIRT1 activation; combine with curcumin. | |
| Curcumin (with piperine) | 500 mg (plus 5 mg piperine) | Dinner | Anti‑inflammatory; take with fat for bioavailability. | |
| Magnesium Threonate | 144 mg | Dinner | Crosses BBB; enhances sleep architecture. | |
| Melatonin (optional) | 0.5 mg | If sleep latency >15 min | Low dose; avoid >2 mg. | |
| Vitamin E (mixed tocopherols) | 200 IU | Dinner | Lipid‑soluble antioxidant. | |
| Probiotic (multi‑strain) | 1 × 10¹⁰ CFU | Dinner | Supports gut‑brain axis. | |
| Advanced Longevity | Rapamycin | 5 mg | Mon‑Wed‑Fri (Phase 1) → 5 mg Mon‑Thu‑Sat (Phase 2) | 2‑week “on/off” cycle; monitor labs (CBC, liver enzymes) & side‑effects. |
| Dasatinib + Quercetin (D+Q) | 100 mg dasatinib + 100 mg quercetin | Day 28 & Day 56 (once/month) | 2‑day “senolytic” window; avoid during high‑intensity training. | |
| Metformin | 500 mg | 2× daily (AM & PM) | If glucose tolerant; monitor GI tolerance & renal function. | |
| Berberine | 500 mg | 2× daily (AM & PM) | Synergistic with metformin; watch for hypoglycemia. | |
| Low‑dose Aspirin | 81 mg | With dinner (if no bleeding risk) | Cardiovascular prophylaxis; re‑evaluate after labs. | |
| Urolithin A | 500 mg | Daily (with dinner) | Mitophagy enhancer; safe for most. | |
| Astaxanthin | 6 mg | Daily (with breakfast) | Powerful antioxidant for skin & brain. | |
| Alpha‑Lipoic Acid | 600 mg | Daily (split AM/PM) | Improves insulin sensitivity, neuroprotective. | |
| L‑Arginine/L‑Citrulline | 3 g citrulline + 1 g arginine | Pre‑HIIT (30 min before) | Boosts nitric oxide, improves vascular flow. |
Cycling Summary
| Supplement | Cycle Length | On‑Days | Off‑Days |
|---|---|---|---|
| Rapamycin | 2 weeks on / 2 weeks off | Mon‑Wed‑Fri (or Mon‑Thu‑Sat) | Tue‑Thu‑Sat (or off) |
| D+Q | 1‑dose per month | Day 28 & Day 56 | — |
| NAD⁺ (NR/NMN) | Daily | — | — |
| Metformin/Berberine | Daily | — | — |
| Senolytics (D+Q) | Monthly | — | — |
| Red‑Light Therapy | Daily | — | — |
| Cold Exposure | Daily (5‑min) | — | — |
| Heat (Sauna) | 2‑3×/week | — | — |
| Phase | Protein | Fat | Carbs | Ketone Target |
|---|---|---|---|---|
| Baseline (Weeks 1‑4) | 2.0 g/kg | 0.8 g/kg | 0.5 g/kg (net) | 0.5‑1.5 mmol/L (fasting) |
| Autophagy‑Boost (Weeks 5‑8) | 2.2 g/kg | 0.8 g/kg | 0.3 g/kg (net) | 1‑2 mmol/L (fasting) |
| Fine‑Tune (Weeks 9‑12) | 2.3 g/kg | 0.9 g/kg | 0.2‑0.4 g/kg (net) | 1.5‑2.5 mmol/L (fasting) |
Example for a 80 kg male:
| Regimen | Window | Frequency | Target |
|---|---|---|---|
| 16:8 Intermittent Fasting | 12:00‑20:00 (eating) / 20:00‑12:00 (fast) | Daily | Baseline metabolic adaptation. |
| Targeted Ketosis | 30‑50 g carbs 30‑60 min pre‑HIIT | 2 × /week | Maintain glycogen for performance while staying mostly keto. |
| Cyclic Ketosis | 3 days “high‑carb” (100‑150 g net carbs) on weekend | Weekly | Re‑fuel muscle glycogen, support mTOR for hypertrophy. |
| 5:2 (Modified) | 500‑600 kcal on two non‑consecutive days (e.g., Sat & Sun) | Every other week | Stimulates deeper autophagy; keep electrolytes high. |
| 24‑h Fast | One full 24‑h fast (e.g., Mon) | Once per month (Week 7) | Maximal autophagy, ketone surge (> 3 mmol/L). |
Electrolyte Strategy (to prevent “keto‑flu”):
| Day | Breakfast (≈ 400 kcal) | Lunch (≈ 600 kcal) | Dinner (≈ 600 kcal) | Snacks |
|---|---|---|---|---|
| Mon | 3 eggs + 2 oz avocado + 1 tbsp MCT oil + 1 cup spinach + 1 tbsp almond butter | 6 oz grilled salmon + 2 cup broccoli + 1 tbsp olive oil + ½ cup cauliflower rice | 6 oz grass‑fed steak + 1 cup asparagus + 1 tbsp butter | 1 oz macadamia nuts + 1 tbsp cheese |
| Tue | 2 scoops whey isolate + 1 tbsp collagen + ½ cup berries + 1 tbsp MCT oil | 4 oz chicken thigh + 2 cup mixed greens + 1 tbsp olive oil + ½ cup olives | 4 oz pork chop + 2 cup sautéed kale + 1 tbsp ghee | 1 oz pumpkin seeds + 1 tbsp dark chocolate (70 %) |
| Wed | 3 egg whites + 1 whole egg + 1 tbsp avocado + 1 tbsp chia seeds + 1 tbsp olive oil | 5 oz sardines + 2 cup mixed veg + 1 tbsp olive oil + ½ cup cauliflower mash | 5 oz turkey breast + 2 cup roasted Brussels sprouts + 1 tbsp butter | 1 oz almonds + 1 tbsp blueberries |
| Thu | 2 scoops whey + 1 tbsp MCT oil + ½ cup frozen raspberries | 6 oz beef strips + 2 cup mixed veg + 1 tbsp coconut oil + ½ cup radish | 6 oz cod + 2 cup sautéed spinach + 1 tbsp olive oil + 1 tbsp pesto | 1 oz walnuts + 1 tbsp pumpkin puree |
| Fri | 3 eggs + 1 oz cheese + 1 tbsp butter + 1 cup kale smoothie (no fruit) | 4 oz shrimp + 2 cup mixed veg + 1 tbsp butter + ½ cup avocado | 6 oz bison + 2 cup roasted zucchini + 1 tbsp olive oil | 1 oz cashews + 1 tbsp unsweetened cocoa powder |
| Sat (Cyclic carbs) | 3 eggs + 1 cup oats (cooked with almond milk) + 1 tbsp butter + ½ cup berries | 5 oz grilled chicken + 1 cup sweet potato + 1 tbsp butter + 2 cup mixed veg | 6 oz salmon + 1 cup quinoa (cooked) + 1 tbsp olive oil + 2 cup veg | 1 oz pistachios + 1 tbsp dark chocolate |
| Sun (5:2) | 1 cup bone broth + 1 tbsp MCT oil + 1 tbsp collagen | 1 cup vegetable soup (low‑carb) + ½ cup olives | 2 oz cottage cheese + 1 tbsp olive oil + 1 cup cucumber slices | 1 oz hemp seeds + 1 tbsp unsweetened almond butter |
Macro Tracking:
| Micronutrient | Target Dose | Food Sources | Supplement if Needed |
|---|---|---|---|
| Vitamin D₃ | 5,000 IU (baseline) → adjust per 25‑OH‑D | Fatty fish, egg yolk, fortified foods | D₃ capsule (if < 40 ng/mL). |
| Vitamin K₂ | 100 µg | Natto, fermented cheese | MK‑7 supplement. |
| Magnesium | 300‑500 mg | Pumpkin seeds, almonds, leafy greens | Glycinate + Threonate combo. |
| Zinc | 30 mg | Oysters, beef, pumpkin seeds | Zinc picolinate (if plasma < 70 µg/dL). |
| Selenium | 200 µg | Brazil nuts (1‑2 nuts) | Selenium supplement (if < 120 µg/L). |
| Vitamin C | 500‑1,000 mg | Citrus, bell peppers | Ester‑C (if < 70 µmol/L). |
| Vitamin E | 200 IU | Almonds, spinach | Mixed tocopherols. |
| Omega‑3 (EPA/DHA) | 2 g | Wild salmon, sardines, algae oil | High‑purity triglyceride fish oil. |
| Probiotic | 1 × 10¹⁰ CFU (multi‑strain) | Fermented foods | Capsule if low diversity. |
| Day | Primary Focus | Session (≈ 60‑90 min) | Key Metrics |
|---|---|---|---|
| Mon | Upper‑Body Strength | 5 × 5 Bench Press, Overhead Press, Rows, Pull‑Ups, Dips (full‑body) | Load progression + RPE (6‑7). |
| Tue | HIIT + Mobility | 15‑min sprint intervals (30 s max effort / 90 s active recovery) + 20‑min mobility flow | Avg HR > 90 % max, HRV drop ≤ 5 ms. |
| Wed | Lower‑Body Strength | 5 × 5 Squat, Deadlift, Leg Press, Lunges, Calf Raises | Load progression + RPE (6‑7). |
| Thu | Light Cardio + Recovery | 30‑min low‑intensity bike/row + 20‑min foam‑roll + 10‑min yoga | Step count ≥ 7,000; Sleep “Readiness” ≥ 80 %. |
| Fri | Upper‑Body Strength (alternate) | Same as Mon but different variation (e.g., incline press, lat pulldown). | Load progression + RPE (6‑7). |
| Sat | HIIT + Cold Exposure | 10‑min Tabata (4 × 20 s sprint/10 s rest) + 5‑min cold shower + 10‑min red‑light therapy. | VO₂max trend + HRV recovery. |
| Sun | Rest / Active Recovery | 30‑min walk, 15‑min meditation, optional sauna (15 min). | Sleep quality, HRV baseline. |
Progression Rules (5 × 5)
HIIT Protocol (e.g., “Sprint‑Interval”)
Recovery Add‑Ons
VO₂max & HRV Tracking
| Technique | Frequency | How to Implement | Metrics |
|---|---|---|---|
| HRV‑Guided Breathing | 5‑min morning & 5‑min evening | Use HRV4Training app; inhale 5 sec, hold 2 sec, exhale 5 sec → repeat. | HRV (RMSSD) baseline > 50 ms. |
| Neurofeedback (Muse) | 10‑min daily (preferably before bed) | Set goal for Alpha (8‑12 Hz) or “Calm” state; visualize waves. | Session score ≥ 80 % “Calm”. |
| Meditation / Mindfulness | 10‑15 min (guided) | Use Insight Timer or Calm; focus on breath, body scan. | Subjective stress rating ↓ 1‑2 points. |
| Cold Exposure | Daily 5‑min cold shower (or 2‑min ice bath) | End shower with 30 sec cold burst; breath control. | ↑ HRV post‑cold (Δ + 5‑10 ms). |
| Heat Therapy (Sauna) | 2‑3×/week, 15‑20 min | Use infrared sauna; hydrate + electrolytes. | ↑ HRV post‑sauna, ↑ endothelial function. |
| Sleep Hygiene | Every night | Dim lights 2 h before bed, blue‑light blockers, consistent 22:00‑07:00 window. | ≥ 85 % deep sleep, ≤ 15 min latency. |
| Cognitive Training | 15‑20 min daily | Anki (spaced‑repetition), Lumosity/Elevate (memory, processing speed). | 1‑2 % improvement in daily recall tasks. |
| Nootropic Stack (Midday) | 30‑45 min post‑lunch | L‑theanine 200 mg + caffeine 200 mg → 1 g citicoline + 300 mg piracetam. | 2‑3 % boost in reaction time; monitor jitteriness. |
| Adaptive Stress Hormone Regulation | 2× day (AM & PM) | Rhodiola 200 mg + Ashwagandha 300 mg (if cortisol > 15 µg/dL). | ↓ cortisol by 10‑15 % after 4 weeks. |
Data Loop:
| Intervention | Dose | Timing | Frequency | Biomarker Target | Monitoring |
|---|---|---|---|---|---|
| Rapamycin | 5 mg (or 1 mg for sensitive) | With dinner | Mon‑Thu‑Sat (Phase 2) | ↓ IGF‑1, ↑ autophagy markers (p‑62) | CBC, LFTs, fasting glucose, lipid panel q‑monthly. |
| Metformin | 500 mg | AM & PM (with meals) | Daily | ↓ fasting glucose, ↓ insulin, ↑ AMPK activation | Fasting glucose, HbA1c q‑month. |
| Berberine | 500 mg | AM & PM | Daily | Similar to metformin; synergy | Same labs. |
| Senolytics (D+Q) | Dasatinib 100 mg + Quercetin 100 mg | 2 days in a row (e.g., Day 28) | Monthly | ↓ senescent cell markers (p16^INK4a) | Blood flow cytometry (optional). |
| NAD⁺ Boosters | NR 250 mg + NMN 100 mg | Morning | Daily | ↑ NAD⁺ levels, improved mitochondrial function | NAD⁺ assay (optional), blood lactate recovery. |
| Urolithin A | 500 mg | Evening | Daily | ↑ mitophagy, improved muscle endurance | Muscle performance tests (e.g., 1‑RM). |
| Resveratrol | 500 mg | Evening | Daily | SIRT1 activation, anti‑inflammatory | CRP, IL‑6 trend. |
| Spermidine | 1 mg | Evening | Daily | Autophagy, neuro‑protection | Plasma spermidine (optional). |
| Photobiomodulation (Red Light) | 660 nm + 850 nm, 10 min | Morning or pre‑workout | Daily | ↑ mitochondrial ATP, skin collagen | No direct labs; subjective energy. |
| HBOT (Hyperbaric O₂) | 2 ATA, 30 min | 2‑3 × /week (post‑strength) | Phase 3 | ↑ stem‑cell mobilization, neuro‑plasticity | No routine labs; monitor ear pressure tolerance. |
| Cryotherapy | Whole‑body 3 min, -110 °C | Post‑HIIT or after strength | 1‑2 × /week | ↑ cold‑induced catecholamines, anti‑inflammatory | HRV rebound, cortisol. |
| Low‑dose Aspirin | 81 mg | Evening | Daily (if no bleeding risk) | ↓ platelet aggregation, cardiovascular risk | Platelet function test q‑3 months. |
Safety & Medical Checks
| Device | Primary Metrics | Frequency | How to Use |
|---|---|---|---|
| Oura Ring | Sleep stages, HRV, Readiness, temperature | Nightly | Set “Sleep Goal” ≥ 8 h; adjust training load if Readiness < 70 %. |
| WHOOP/Strap | Strain, Recovery, HRV, Sleep | Continuous | Use “Strain Coach” to avoid over‑training; aim for 70‑80 % recovery before next HIIT. |
| Apple Watch Series 8 | VO₂max, HR zones, ECG, step count | Continuous | Track “Active Calories” vs “Rest Calories”; calibrate VO₂max monthly. |
| Dexcom G6 CGM | Real‑time glucose, ketones (via sensor) | Continuous | Verify fasting glucose < 80 mg/dL, postprandial < 100 mg/dL; use data to fine‑tune carb timing. |
| Smart Scale (Withings Body+) | Weight, BF%, muscle mass, BMI | Weekly | Adjust protein/fat intake if BF% rises > 1 %/mo. |
| HRV4Training App | RMSSD, HF, LF | Daily morning | Set HRV target; if drop > 10 ms, consider active recovery or reduce load. |
| Muse Headband | Neurofeedback “Calm” score, EEG patterns | Daily (pre‑bed) | Use to train vagal tone; aim for > 80 % “Calm” after 2 weeks. |
| Cronometer | Macro & micronutrient intake | Daily | Ensure > 95 % of RDA for all vitamins/minerals. |
| Lab Results Tracker (Notion) | Blood biomarkers, supplement log | Monthly | Create a “Trend Table” for each marker; flag any > 10 % deviation. |
Weekly Review Workflow
Below is a template you can copy into a spreadsheet. Adjust the exact days of rapamycin, D+Q, and carb‑re‑feed based on your schedule.
| Week | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| 1 | Strength Upper (5×5) – Rapamycin 5 mg | HIIT + Mobility | Strength Lower (5×5) | Light Cardio + Recovery | Strength Upper (alternate) – Rapamycin 5 mg | HIIT + Cold Shower | Rest + Sauna (15 min) |
| 2 | Strength Upper (deload) – Rapamycin off | HIIT + Mobility | Strength Lower (deload) | Light Cardio + Recovery | Strength Upper (deload) – Rapamycin off | HIIT + Red‑Light (10 min) | Rest + Meditation |
| 3 | Strength Upper (load ↑ 2.5 %) – Rapamycin on | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin on | HIIT + Cold Shower | Rest + Sauna |
| 4 | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Red‑Light + D+Q (Day 28) | Rest + Meditation |
| 5 | Strength Upper (load ↑ 2.5 %) – Rapamycin on (Mon‑Thu‑Sat) | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin on | HIIT + Cold + Red‑Light | Rest + Sauna |
| 6 | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Cold + Red‑Light | Rest + Meditation |
| 7 | 24‑h Fast (Mon) – No rapamycin | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Cold + Red‑Light | Rest + Sauna |
| 8 | Strength Upper (load ↑ 2.5 %) – Rapamycin on | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin on | HIIT + Cold + Red‑Light | Rest + Meditation |
| 9 | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Cold + Red‑Light + D+Q (Day 56) | Rest + Sauna |
| 10 | Strength Upper (load ↑ 2.5 %) – Rapamycin on (Mon‑Thu‑Sat) | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin on | HIIT + Cold + Red‑Light | Rest + Meditation |
| 11 | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin off | HIIT + Cold + Red‑Light | Rest + Sauna |
| 12 | Strength Upper (load ↑ 2.5 %) – Rapamycin on (final) | HIIT + Mobility | Strength Lower (load ↑ 2.5 %) | Light Cardio + Recovery | Strength Upper (load ↑ 2.5 %) – Rapamycin on | HIIT + Cold + Red‑Light + HBOT (2×) | Rest + Final Review + Lab Draw |
Key: “Load ↑ 2.5 %” = increase bar weight by 2.5 % (or add 1 rep) each week. “Rapamycin on/off” follows the 2‑week cycle (on Mon‑Thu‑Sat, off Tue‑Fri‑Sun). “D+Q” occurs on Day 28 and Day 56. “HBOT” optional, schedule 2 sessions in Week 12.
| Timepoint | Tests | Rationale |
|---|---|---|
| Baseline (Week 0) | CBC, CMP, fasting glucose, HbA1c, lipid panel, CRP, IL‑6, fasting insulin, 25‑OH‑D, B12, folate, magnesium, zinc, selenium, thyroid (TSH, free T4), cortisol (AM), DHEA‑S, NAD⁺ (optional), telomere length (optional). | Establish baseline, detect hidden deficiencies, set dosing thresholds. |
| Month 1 | Same + repeat NAD⁺ (if measured), add fasting ketone (β‑HB) via blood test. | Check early response to diet & supplements. |
| Month 2 | Same + add senescent cell markers (p16^INK4a) if available, repeat rapamycin safety labs (ALT/AST, creatinine). | Verify rapamycin tolerance, early autophagy signals. |
| Month 3 | Full repeat + optional DNA methylation age (e.g., Horvath clock), telomere length (if measured), comprehensive metabolic panel, and post‑intervention labs for rapamycin, D+Q, metformin. | Evaluate long‑term impact, adjust future regimen. |
Interpretation Guidelines (approx.)
Safety Flags (stop or consult physician):
| Category | Daily Action | Frequency | Notes |
|---|---|---|---|
| Hydration & Electrolytes | 2 L water + ½ tsp sea‑salt + ¼ tsp potassium citrate | Daily | Adjust on high‑intensity days (+ 200 ml). |
| Sunlight | 10‑15 min natural light (no sunglasses) | Morning | Align with circadian rhythm. |
| Supplement Morning | Vitamin D₃, K₂, Omega‑3, Mg‑glycinate, PQQ, NR + NMN | Daily | Set alarm for 07:00. |
| Supplement Midday | CoQ10, L‑carnitine, Alpha‑GPC, Rhodiola, Vitamin C | Daily | Take with lunch. |
| Supplement Evening | Spermidine, Resveratrol, Curcumin, Mg‑threonate, Melatonin (if needed), Probiotic | Daily | Take with dinner. |
| Rapamycin | 5 mg capsule | Mon‑Thu‑Sat (2‑week on/off) | Check liver enzymes monthly. |
| D+Q | 100 mg dasatinib + 100 mg quercetin | Day 28 & Day 56 | Use with food; monitor blood pressure. |
| Metformin/Berberine | 500 mg each | AM & PM | Keep with meals; watch GI tolerance. |
| Exercise | Strength (5×5) + HIIT (2×/wk) + Mobility (daily) | As per weekly schedule | Log sets, reps, RPE. |
| Cold Exposure | 5‑min cold shower or ice bath | Daily (or post‑HIIT) | Use timer; breathe steadily. |
| Sauna | 15‑20 min IR sauna | 2‑3×/wk | Hydrate + electrolytes. |
| Red Light | 10‑min forehead + 10‑min lower back | Daily | Use 660 nm + 850 nm device. |
| Neurofeedback | Muse 10‑min session | Daily (pre‑bed) | Aim for “Calm” > 80 %. |
| HRV Breathing | 5‑min guided breathing | Morning & Evening | Use HRV4Training. |
| Cognitive Training | Anki + Lumosity | Daily 15‑20 min | Focus on spaced‑repetition. |
| Sleep | 7‑9 h, dark room, 22:00‑07:00 window | Nightly | Aim ≥ 85 % deep sleep. |
| Data Logging | Enter HRV, CGM, step count, sleep, mood | Every morning | Review trends weekly. |
| Lab Review | Upload results, note changes | Monthly | Adjust supplement stack. |
| Safety Check | Review any side‑effects, med interactions | Weekly | Stop rapamycin/D+Q if labs abnormal. |
Data‑Driven Decision Tree (Simplified)
If HRV drop >10ms AND fasting glucose >90mg/dL → Reduce fasting window (e.g., 14:10) + add 20g carbs pre‑HIIT.
If ALT/AST >2×ULN → Stop rapamycin for 2 weeks, re‑test.
If IGF‑1 <100ng/mL AND muscle loss >2% → Increase protein to 2.5g/kg, add creatine 5g daily.
If DHEA‑S <300µg/dL → Add Ashwagandha 300mg morning + evening.
If CRP >2mg/L → Increase Omega‑3 to 3g, add curcumin 500mg, consider intermittent fasting longer (e.g., 18:6).
If NAD⁺ <50µM → Increase NR/NMN dose (300mg/150mg) or add urolithin A.
| Metric | Expected Change (by end of month 3) | Supporting Evidence |
|---|---|---|
| Fasting Glucose | ↓ 10‑15 mg/dL (≈ 5‑10 % improvement) | Ketogenic + rapamycin + metformin synergy. |
| HbA1c | ↓ 0.2‑0.3 % | Low‑carb + intermittent fasting. |
| CRP | ↓ 15‑30 % | Omega‑3, curcumin, vitamin D, fasting. |
| VO₂max | ↑ 2‑3 % (or + 2 ml/kg/min) | HIIT + mitochondrial boosters (PQQ, urolithin A). |
| Lean Body Mass | ↑ 1‑2 % (≈ 0.5‑1 kg) | 5 × 5 strength + creatine + adequate protein. |
| Sleep Deep % | ↑ 10‑15 % | Red‑light, magnesium threonate, consistent schedule. |
| HRV (RMSSD) | ↑ 5‑10 ms | HRV breathing, cold exposure, adaptogens. |
| NAD⁺ Levels | ↑ 30‑50 % (if measured) | NR/NMN daily, urolithin A, fasting. |
| Senescent Cell Markers | ↓ 10‑20 % (if measured) | D+Q senolytics. |
| Cognitive Speed | ↑ 2‑5 % (reaction time) | L‑theanine + caffeine + citicoline + training. |
| Blood Pressure | ↓ 5‑10 mmHg (if hypertensive) | Rapamycin, weight loss, sodium restriction. |
Individual results vary; re‑test labs to confirm.
| Intervention | Red Flags | When to Pause/Stop |
|---|---|---|
| Rapamycin | ALT/AST > 2×ULN, creatinine ↑, severe fatigue, infections, wound healing issues | Stop immediately; consult physician. |
| Metformin | GI upset, lactic acidosis risk (renal impairment, severe liver disease) | Reduce dose or stop; monitor renal function. |
| Berberine | Hypoglycemia, drug interactions (warfarin, cyclosporine) | Stop if on anticoagulants; monitor glucose. |
| Senolytics (D+Q) | Blood pressure spikes, nausea, bruising, platelet count changes | Stop if any adverse event; re‑test CBC. |
| High‑dose Vitamin D | Hypercalcemia (calcium > 10.5 mg/dL) | Reduce dose; monitor calcium. |
| Cold Exposure | Frostbite, cardiovascular stress (e.g., uncontrolled hypertension) | Limit to 5‑min, avoid if heart condition. |
| Sauna | Dehydration, low blood pressure, recent illness | Hydrate, limit sessions if feeling dizzy. |
| HBOT | Ear pressure injury, claustrophobia, uncontrolled diabetes | Contraindicated for uncontrolled hypertension or severe COPD. |
| Neurofeedback (Muse) | Seizure risk (if epileptic) | Avoid if seizure history. |
Always have a qualified clinician review labs before starting rapamycin, senolytics, or any prescription‑level intervention.
Now you have a full‑featured, data‑driven, cutting‑edge longevity plan that can be executed over the next 12 weeks.
| Pillar | What to Do | When |
|---|---|---|
| Diet | 16:8 IF + targeted carbs + cyclic keto; 30‑40 g protein per meal; electrolytes daily | Every day |
| Supplements | Morning: D₃, K₂, Omega‑3, Mg‑glycinate, PQQ, NR+NMN. Midday: CoQ10, L‑carnitine, Alpha‑GPC, Rhodiola, Vitamin C. Evening: Spermidine, Resveratrol, Curcumin, Mg‑threonate, Probiotic, Melatonin (if needed). Add rapamycin (5 mg Mon‑Thu‑Sat), D+Q (monthly), Metformin/Berberine (daily). | Daily (with timing as above) |
| Exercise | 5 × 5 strength 3×/wk + HIIT 2×/wk + daily mobility + weekly cold/heat + weekly sauna/HBOT | Structured weekly |
| Stress/Cognitive | HRV breathing 5 min AM/PM, Muse neurofeedback 10 min nightly, meditation 10 min, adaptogens (Rhodiola, Ashwagandha) | Daily |
| Wearables | Oura, WHOOP, Apple Watch, Dexcom, smart scale | Continuous |
| Testing | Labs baseline → month 1 → month 2 → month 3; monitor glucose, HRV, VO₂max, body comp. | Every month |
| Adjustments | Based on HRV, glucose, labs, performance; tweak fasting, load, supplement cycles. | Weekly review |
Follow the template, keep meticulous logs, and iterate. Within three months you should see measurable improvements in metabolic health, physical strength, sleep quality, and cognitive sharpness—while also moving the needle on the molecular hallmarks of aging.
Good luck, stay data‑driven, and remember: safety first!
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