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© 2026 Rival
  1. Home
  2. Models
  3. Claude Haiku 4.5
  4. Advanced Longevity Plan (Biohacker)

See how Claude Haiku 4.5 compares on this challenge:

  • Claude Haiku 4.5 vs Claude Sonnet 4.6
  • Claude Haiku 4.5 vs Gemini 3.1 Pro Preview
  • Claude Haiku 4.5 vs Z.ai: GLM 5

4 models have responded to the "Advanced Longevity Plan (Biohacker)" challenge. Compare their approaches side-by-side on RIVAL. This response is part of RIVAL's open dataset of 5,600+ AI model responses.

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Back to Claude Haiku 4.5

Advanced Longevity Plan (Biohacker)

Claude Haiku 4 5's response to the 'Advanced Longevity Plan (Biohacker)' challenge.

Claude Haiku 4.5
February 4, 2026
Text

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Prompt

Develop a comprehensive, cutting-edge 3-month longevity plan for a biohacker aiming to optimize longevity, physical and cognitive performance. Incorporate advanced strategies like specific supplement stacks (with dosages and cycling), detailed dietary protocols (e.g., ketogenic variations, fasting regimens), advanced wearable tracking, personalized exercise routines (including strength, HIIT, and recovery), stress resilience techniques (e.g., HRV training, neurofeedback concepts), among other things. The plan should be highly detailed and actionable.

Claude Haiku 4.5
Response

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Claude Haiku 4.5Advanced Longevity Plan (Biohacker)
claude-haiku-4.5 logo
Claude Haiku 4.5

Comprehensive 3-Month Longevity Optimization Plan

TABLE OF CONTENTS

  1. Foundation & Assessment
  2. Nutritional Architecture
  3. Supplement Stack Protocol
  4. Exercise & Movement System
  5. Recovery & Sleep Optimization
  6. Stress Resilience & Cognitive Enhancement
  7. Tracking & Biofeedback
  8. Implementation Timeline
  9. Monthly Progression
  10. Troubleshooting & Adaptation

PHASE 0: FOUNDATION & ASSESSMENT (Week 1)

Baseline Testing

Before starting, establish metrics:

TestMethodFrequency
Lipid PanelBloodworkBaseline + Week 12
Fasting Glucose/InsulinBloodworkBaseline + Week 12
HbA1cBloodworkBaseline + Week 12
hs-CRPBloodworkBaseline + Week 12
HomocysteineBloodworkBaseline + Week 12
Testosterone/DHEABloodworkBaseline + Week 12
Thyroid Panel (TSH, Free T3, Free T4)BloodworkBaseline + Week 12
Vitamin D25-OHBloodworkBaseline + Week 12
VO2 MaxSubmaximal test or GarminBaseline + Week 12
Body CompositionDEXA or InBodyBaseline + Week 12
Resting Heart RateWearableDaily tracking
HRV (Heart Rate Variability)WearableDaily tracking
Cognitive BaselineNIH Toolbox or LumosityBaseline + Week 12
Grip StrengthDynamometerBaseline + Week 12

Genetic Testing (Optional but Recommended):

  • Nutrigenomix or DNAlife for personalized nutrition
  • 23andMe + Promethease for SNP analysis (MTHFR, ApoE, etc.)

PART 1: NUTRITIONAL ARCHITECTURE

Phase 1A: Weeks 1-4 (Metabolic Reset & Baseline)

Macronutrient Framework

Caloric Target: Maintenance (calculate: BMR × 1.4-1.5)

  • Adjust based on goals (fat loss: -300-500 cal; muscle gain: +200-300 cal)

Macro Split:

  • Protein: 1.0-1.2g per lb bodyweight
  • Fat: 0.8-1.0g per lb bodyweight
  • Carbs: Remaining calories (typically 30-40% of total)

Example for 200lb male (2,500 cal maintenance):

  • Protein: 200-240g (800-960 cal)
  • Fat: 160-200g (1,440-1,800 cal)
  • Carbs: 150-200g (600-800 cal)

Dietary Protocol: Metabolic Flexibility Foundation

Daily Eating Window:

  • 11am-7pm (8-hour window) or 12pm-8pm
  • Adjust based on circadian preference and training schedule

Meal Structure:

Meal 1 (11am-12pm) - Post-Fasting Meal:

  • 40-50g protein (grass-fed beef, wild fish, pastured eggs)
  • 30-40g carbs (white rice, sweet potato, oats)
  • 15-20g fat (olive oil, avocado, nuts)
  • Micronutrient density: leafy greens, colorful vegetables
  • Rationale: Break fast with easily digestible carbs + protein to spike mTOR moderately

Example:

  • 8oz grass-fed beef or wild salmon
  • 1 cup white rice or 2 medium sweet potatoes
  • 2 cups mixed greens with olive oil dressing
  • 1 apple

Meal 2 (3-4pm) - Pre-Training Meal (if training 4-5pm):

  • 30-40g protein
  • 40-60g carbs (if training; lower if rest day)
  • 10-15g fat
  • Low fiber to avoid GI distress

Example:

  • 2 scoops whey isolate or 6oz chicken breast
  • 1.5 cups white rice or 2 rice cakes + honey
  • Pinch of sea salt

Meal 3 (6-7pm) - Post-Training/Dinner:

  • 40-50g protein
  • 25-35g carbs (prioritize if trained hard)
  • 20-25g fat
  • Higher micronutrient density

Example:

  • 8oz grass-fed beef or wild-caught salmon
  • 150g white rice or 2 medium potatoes
  • 2 cups vegetables (broccoli, asparagus, carrots)
  • 1 tbsp butter or coconut oil

Phase 1A Dietary Rules

✓ Prioritize:

  • Grass-fed beef, pastured poultry, wild-caught fish (salmon, sardines, mackerel)
  • Organic vegetables (especially cruciferous, leafy greens)
  • White rice, white potatoes (lower antinutrient load)
  • Pasture-raised eggs (3-5 daily)
  • Fermented foods (sauerkraut, kimchi, kefir)
  • Bone broth (1-2 cups daily for collagen + minerals)

✗ Eliminate:

  • Seed oils (canola, soybean, sunflower)
  • Processed foods, refined carbs
  • Added sugars (except post-workout)
  • Alcohol (first 4 weeks; reintroduce week 5)
  • Gluten (test reintroduction week 5)
  • Excess dairy (except butter, ghee, fermented)

Hydration Protocol

  • Baseline: 0.5-1oz per lb bodyweight daily
  • Add: 500-1000ml per hour of exercise
  • Electrolytes:
    • Morning: 1/4 tsp sea salt in water with lemon
    • Post-workout: 500-1000mg sodium, 300-400mg potassium, 100-200mg magnesium
    • Product: LMNT, Nuun, or DIY (sea salt + potassium citrate + magnesium glycinate)

Phase 1B: Weeks 5-8 (Metabolic Flexibility Deepening)

Transition to Ketogenic Variation

Objective: Increase mitochondrial density, fat oxidation, autophagy signaling

Protocol: 4-Day Keto / 3-Day Refeed Cycle

Keto Days (Mon, Tue, Thu, Fri):

  • Protein: 1.0-1.2g/lb
  • Fat: 1.2-1.5g/lb
  • Carbs: <30g (net carbs)
  • Calories: Maintenance to -200 (fat loss focus)

Example Keto Day (200lb male):

  • Meal 1 (11am): 8oz salmon, 2 tbsp MCT oil, 3 cups spinach, 1 avocado
    • P: 50g | F: 65g | C: 8g
  • Meal 2 (3pm): 6oz grass-fed beef, 2 tbsp ghee, 4 cups mixed greens
    • P: 40g | F: 50g | C: 4g
  • Meal 3 (6:30pm): 8oz pastured chicken thighs, 1/4 cup macadamia nuts, broccoli with butter
    • P: 50g | F: 55g | C: 6g

Daily Total: P: 140g | F: 170g | C: 18g | ~2,500 cal

Refeed Days (Wed, Sat, Sun):

  • Protein: 1.0-1.2g/lb
  • Fat: 0.6-0.8g/lb
  • Carbs: 1.5-2.0g/lb
  • Calories: Maintenance to +200 (replenish glycogen)

Example Refeed Day (200lb male):

  • Meal 1 (11am): 8oz beef, 1.5 cups white rice, 2 tbsp olive oil, vegetables
    • P: 50g | F: 35g | C: 60g
  • Meal 2 (3pm): 6oz chicken, 1.5 cups white rice, 1 tbsp honey
    • P: 40g | F: 15g | C: 70g
  • Meal 3 (6:30pm): 8oz salmon, 1 cup sweet potato, 1 tbsp butter, vegetables
    • P: 50g | F: 25g | C: 50g

Daily Total: P: 140g | F: 75g | C: 180g | ~2,700 cal

Timing Optimization

Keto Days:

  • Fasting window: 7pm-11am (16 hours)
  • Rationale: Maximize fat oxidation, autophagy signaling

Refeed Days:

  • Carbs concentrated around training (if trained) or early/mid-day
  • Break fast at 10-11am with carbs
  • Rationale: Replenish glycogen, spike insulin for mTOR signaling

Intermittent Fasting Progression

  • Weeks 5-6: 14-hour fasts (7pm-9am)
  • Weeks 7-8: 16-hour fasts (7pm-11am) on keto days
  • Optional Week 8: One 24-hour fast (dinner to dinner) mid-week for autophagy

Phase 1C: Weeks 9-12 (Advanced Metabolic Cycling)

Introduce Targeted Carb Cycling

Objective: Optimize performance, recovery, and metabolic adaptation

Weekly Template:

DayTypeCarbsPurpose
MonHeavy StrengthRefeed (1.5-2g/lb)Glycogen for strength
TueHIITModerate (0.8-1g/lb)Glycogen + fat loss
WedKeto<30gAutophagy, fat oxidation
ThuModerateModerate (0.8-1g/lb)Recovery, flexibility
FriStrengthRefeed (1.5-2g/lb)Glycogen for strength
SatLow-IntensityLow (0.3-0.5g/lb)Fat oxidation, recovery
SunRefeedHigh (1.5-2g/lb)Glycogen replenishment

Nutrient Timing Precision

Pre-Workout (30-60 min before, high-carb days):

  • 30-40g fast carbs (white rice, honey, rice cakes)
  • 15-20g protein (whey isolate)
  • Minimal fat/fiber
  • Example: 2 rice cakes + 1 tbsp honey + 1 scoop whey isolate

Intra-Workout (if >60 min):

  • 10-20g fast carbs
  • 5-10g BCAA or EAA
  • 500-1000ml electrolyte solution
  • Example: 10g dextrose + 7g BCAA + LMNT in water

Post-Workout (within 30-60 min):

  • 40-60g fast carbs
  • 30-40g protein
  • Minimal fat/fiber
  • Example: 1.5 cups white rice + 8oz chicken breast

PART 2: SUPPLEMENT STACK PROTOCOL

Tier 1: Essential Foundation (All 12 Weeks)

Objective: Fill micronutrient gaps, support basic longevity pathways

2.1 Micronutrient Stack

SupplementDoseTimingRationale
Vitamin D34,000-5,000 IUMorning with fatImmune, bone, mood, longevity
Magnesium Glycinate400-500mgEveningSleep, stress, muscle, cardiac
Omega-3 (Fish Oil)2-3g EPA/DHAWith mealsAnti-inflammatory, cognitive, cardiac
Zinc Picolinate15-25mgMorning (alternate days)Immune, testosterone, recovery
Selenium200mcgMorningThyroid, antioxidant, mood
Vitamin K2 (MK-7)90-180mcgWith fat-soluble vitaminsBone, cardiovascular, longevity
Folate (L-Methylfolate)400-800mcgMorningMethylation, cognitive, homocysteine
B12 (Methylcobalamin)1,000-2,000mcgMorning or sublingualEnergy, methylation, cognitive
Iron (if deficient)15-25mg elementalMorning, separate from othersEnergy, oxygen transport

Cycling: All daily, no cycling needed

Stacking Strategy:

  • Morning (with breakfast): D3 + K2 + Omega-3 + Folate + B12 + Zinc (alternate days)
  • Evening (with dinner): Magnesium Glycinate + Omega-3 + Selenium

2.2 Mitochondrial Support Stack

SupplementDoseTimingRationale
CoQ10 (Ubiquinol)200-300mgMorning with fatMitochondrial energy, cardiac, antioxidant
L-Carnitine2-3gPre-workout or morningFat oxidation, mitochondrial function
Acetyl-L-Carnitine (ALCAR)1-2gMorningCognitive, mitochondrial, neuroprotection
Creatine Monohydrate5g dailyAnytime with carbsStrength, power, cognitive, neuroprotection
PQQ (Pyrroloquinoline Quinone)10-20mgMorningMitochondrial biogenesis, antioxidant
NAD+ Precursor (NMN or NR)250-500mgMorningNAD+ levels, sirtuin activation, longevity

Cycling: All daily, no cycling needed

Stacking Strategy:

  • Morning: CoQ10 + PQQ + NMN/NR with breakfast
  • Pre-workout: L-Carnitine + Creatine with carbs
  • Anytime: ALCAR with meals

2.3 Antioxidant & Anti-Inflammatory Stack

SupplementDoseTimingRationale
Curcumin (95% Curcuminoids)500-1,000mgWith black pepper (Piperine 5-10mg)Anti-inflammatory, antioxidant, cognitive
Resveratrol150-300mgMorningSirtuin activation, antioxidant, longevity
Quercetin500-1,000mgMorningAnti-inflammatory, senolytic, antioxidant
Astaxanthin4-12mgMorning with fatAntioxidant, eye health, recovery
Alpha-Lipoic Acid (ALA)300-600mgMorning or with mealsAntioxidant, blood sugar, mitochondrial
N-Acetyl Cysteine (NAC)600-1,200mgMorningGlutathione precursor, detoxification
Sulforaphane (Broccoli Sprout Extract)50-100 μmolMorningNRF2 activation, detoxification, longevity

Cycling (Weeks 1-12):

  • Continuous daily (no cycling needed)
  • Optional: 1 week off per month for receptor sensitivity

Stacking Strategy:

  • Morning Stack: Curcumin + Piperine + Resveratrol + Quercetin + Astaxanthin + ALA with breakfast
  • Separate: NAC (1-2 hours away from minerals), Sulforaphane with meal

Tier 2: Performance & Cognitive Enhancement (All 12 Weeks)

2.4 Cognitive Enhancement Stack

SupplementDoseTimingRationaleCycling
Alpha-GPC600-1,200mgMorning, split dosesCholine source, focus, memory, growth hormoneDaily
L-Theanine100-200mgMorning or as neededCalm focus, alpha waves, synergistic with caffeineDaily
Caffeine100-200mgMorning (6-8am)Alertness, performance, longevityDaily or 5 days/week
Rhodiola Rosea (3% Rosavins)300-600mgMorningStress resilience, fatigue, cognitive5 weeks on / 1 week off
Lion's Mane Mushroom (10:1)500-1,500mgMorning or splitNGF stimulation, cognitive, neuroprotectionDaily
Bacopa Monnieri (50% Bacosides)300-600mgMorning or splitMemory, learning, anxiety, neuroprotectionDaily
L-Tyrosine500-1,500mgMorning or pre-workoutDopamine, focus, stress resilienceDaily
Ginkgo Biloba (24% Flavones)120-240mgMorning, split dosesCognitive, blood flow, neuroprotectionDaily

Stacking Strategy:

  • Morning (7-8am): Caffeine + L-Theanine + Alpha-GPC + Rhodiola + Lion's Mane
  • Mid-morning (10am): Bacopa + Ginkgo
  • Pre-workout: L-Tyrosine (if not stimulated already)

Caffeine Cycling (Weeks 1-12):

  • Weeks 1-4: Daily 100-150mg (6-8am only)
  • Weeks 5-8: 5 days/week (Mon-Fri), off weekends
  • Weeks 9-12: 3 days/week (Mon, Wed, Fri) for sensitivity maintenance

2.5 Longevity & Senolytic Stack

SupplementDoseTimingRationaleCycling
Fisetin100-200mgMorningSenolytic, antioxidant, neuroprotection2 weeks on / 2 weeks off
Dasatinib5mg (if available)Once, mid-protocolSenolytic, cellular aging1 dose at Week 6 (consult MD)
Rapamycin (Sirolimus)5-10mg weeklyOnce weekly (suggest Mon)mTOR inhibition, autophagy, longevity1x weekly (consult MD)
Metformin500-1,000mgDinnerInsulin sensitivity, longevity, AMPKDaily (if approved; consult MD)
Spermidine1-2mgMorningAutophagy, mitochondrial, longevityDaily
Nicotinamide Riboside (NR)250-500mgMorningNAD+ precursor, sirtuin activationDaily (or alternate with NMN)

Cycling Strategy:

  • Fisetin: 2 weeks on (100-200mg daily) / 2 weeks off (rotate with Quercetin)
  • Dasatinib: Single dose at Week 6 (medical supervision recommended)
  • Rapamycin: 5-10mg once weekly (Monday) - requires prescription
  • Metformin/NR/Spermidine: Daily continuous

Note: Rapamycin and Dasatinib require physician oversight. Consider consulting a longevity-focused MD (e.g., through Fountain Life, Orca Health).


2.6 Sleep & Recovery Stack

SupplementDoseTimingRationaleCycling
Magnesium Glycinate300-500mg30-60 min before bedSleep, muscle relaxation, stressDaily
L-Glycine3-5gBefore bedSleep quality, collagen, recoveryDaily
Melatonin0.5-5mg30-60 min before bedSleep-wake cycle, antioxidant5 nights/week (avoid tolerance)
Apigenin50-100mgBefore bedSleep, anxiety, GABA enhancementDaily
Ashwagandha (KSM-66, 5% Withanolides)300-600mgEveningStress, cortisol, sleep qualityDaily
Valerian Root Extract400-900mgBefore bedSleep onset, deep sleep4 weeks on / 1 week off
Passionflower250-500mgBefore bedAnxiety, sleep quality, GABADaily

Stacking Strategy:

  • 30-60 min before bed: Magnesium Glycinate + L-Glycine + Apigenin + Ashwagandha + Passionflower + Melatonin (5 nights/week)
  • Valerian: Rotate in weeks 1-4, 5-9, off weeks 10-12

Tier 3: Training-Specific Stack (Varies by Phase)

2.7 Strength & Muscle Building (Weeks 1-12, emphasize Mon/Fri)

SupplementDoseTimingRationale
Creatine Monohydrate5g dailyPost-workout with carbsStrength, power, muscle, neuroprotection
Beta-Alanine3-5g dailySplit doses with mealsEndurance, buffering, strength endurance
Citrulline Malate6-8g30-60 min pre-workoutPump, endurance, blood flow, recovery
Betaine (Trimethylglycine)2.5-5gMorning or pre-workoutStrength, power, endurance, recovery
Taurine3-5gPre/post-workout or dailyMuscle function, recovery, cardiac, neuroprotection
Leucine (if needed)2-3gPost-workoutmTOR activation, muscle protein synthesis

Stacking Strategy:

  • Pre-workout (30-60 min before): Citrulline Malate + Beta-Alanine + Betaine
  • Post-workout (within 60 min): Creatine + Leucine with carbs + protein
  • Daily: Taurine (morning or split)

2.8 HIIT & Fat Loss Stack (Weeks 5-12, emphasize Tue/Sat)

SupplementDoseTimingRationale
Green Tea Extract (EGCG)300-500mgMorning or pre-workoutFat oxidation, thermogenesis, antioxidant
Caffeine100-200mgPre-workoutEnergy, fat oxidation, performance
L-Carnitine2-3gPre-workout or morningFat oxidation, mitochondrial, endurance
Yohimbine5-10mgFasted morning (optional)Fat oxidation, sympathomimetic
Capsaicin (Cayenne Extract)100-300mgWith mealsThermogenesis, anti-inflammatory

Stacking Strategy:

  • Pre-HIIT: Caffeine + L-Carnitine + Green Tea Extract (30-60 min before)
  • Fasted morning (optional): Yohimbine + L-Carnitine (if doing fasted cardio)
  • Daily: Capsaicin with meals

2.9 Recovery & Injury Prevention Stack (All 12 Weeks)

SupplementDoseTimingRationale
Collagen Peptides (Type I/III)10-20gMorning or post-workoutJoint, skin, gut, recovery
Glucosamine + Chondroitin1,500mg + 1,200mgDaily with mealsJoint cartilage, mobility, longevity
Hyaluronic Acid50-200mgMorningJoint, skin, connective tissue
Boswellia Serrata (65% Boswellic Acids)300-500mgMorning or eveningJoint inflammation, mobility, recovery
Bromelain (Pineapple Enzyme)500-1,000 GDUBetween meals or post-workoutInflammation, recovery, protein digestion
Vitamin C (Ascorbic Acid)500-1,000mgMorning or splitCollagen synthesis, antioxidant, immune

Stacking Strategy:

  • Morning: Collagen + Glucosamine + Chondroitin + Hyaluronic Acid + Vitamin C
  • Post-workout: Collagen + Bromelain (or with separate meal)
  • Evening: Boswellia

Tier 4: Advanced/Optional Stack (Weeks 5-12)

2.10 Advanced Longevity & Biohacking

SupplementDoseTimingRationaleNotes
Exosome TherapyAs prescribedPer providerCellular rejuvenation, tissue repairOptional; requires medical provider
Senolytics (Quercetin + Dasatinib)See Tier 2IntermittentSenescent cell clearance2-week protocols quarterly
Urolithin A250-500mgMorningMitochondrial health, autophagyEmerging; limited human data
Pterostilbene50-100mgMorningSirtuin activation, cognitiveResveratrol analog
Nicotinamide Mononucleotide (NMN)250-500mgMorningNAD+ elevation, longevityAlternate with NR
Hyaluronic Acid (IV)As prescribedPer providerSkin, joint, systemic hydrationOptional; medical provider
Stem Cell TherapyAs prescribedPer providerTissue regenerationAdvanced; significant cost
Plasmapheresis/Plasma ExchangeAs prescribedPer providerParabiosis benefit simulationExperimental; limited evidence

PART 3: EXERCISE & MOVEMENT SYSTEM

Overview: Periodized Training Architecture

Objective: Maximize strength, power, endurance, mitochondrial function, and longevity markers while managing fatigue and injury risk.

Weekly Structure:

  • 4 Strength Days (Mon, Tue, Thu, Fri)
  • 2 Conditioning Days (Tue, Sat)
  • 1 Complete Rest or Active Recovery (Wed, Sun)

Phase 1: Weeks 1-4 (Hypertrophy & Metabolic Foundation)

3.1 Monday: Lower Body Hypertrophy + Metabolic Stress

Warm-up (5-10 min):

  • 2 min light rowing or jumping jacks
  • Cat-cow stretches, leg swings
  • Bodyweight squats x 10

Main Work (45-50 min):

ExerciseSets x RepsTempoRestNotes
Barbell Back Squat4 x 6-83-1-13 minHeavy, focus on depth
Romanian Deadlift (RDL)3 x 8-102-1-22.5 minHamstring emphasis
Leg Press3 x 8-122-1-12 minHigher reps, metabolic stress
Walking Lunges3 x 12 each leg2-0-190 secUnilateral, balance
Leg Curl3 x 12-151-1-290 secHamstring isolation
Calf Raises3 x 15-201-0-160 secHigh reps for endurance

Metabolic Finisher (5-10 min):

  • 3 rounds: 20 goblet squats + 20 jump rope
  • Rest 60 sec between rounds
  • Rationale: Spike lactate, growth hormone, metabolic stress

Post-Workout:

  • 5 min easy stretching (quads, hamstrings, hip flexors)
  • Consume post-workout meal within 60 min

3.2 Tuesday: Upper Body Hypertrophy + HIIT Conditioning

Warm-up (5-10 min):

  • 2 min rowing machine
  • Arm circles, band pull-aparts, push-ups x 10

Main Work (50-55 min):

ExerciseSets x RepsTempoRestNotes
Bench Press (Barbell or Dumbbell)4 x 6-83-1-13 minHeavy, chest emphasis
Bent-Over Barbell Rows4 x 6-82-1-13 minBack thickness, strength
Incline Dumbbell Press3 x 8-102-1-12 minUpper chest, anterior shoulder
Weighted Pull-ups or Lat Pulldown3 x 6-102-1-12 minVertical pull, back width
Dumbbell Flyes3 x 10-122-1-290 secChest stretch, isolation
Barbell Curls3 x 8-102-1-190 secArm development
Tricep Dips or Pushdowns3 x 10-122-0-190 secArm development

HIIT Conditioning (15-20 min):

  • Rowing machine or bike: 30 sec all-out + 90 sec easy (8 rounds)
  • Rationale: VO2 max, fat oxidation, mitochondrial density

Post-Workout:

  • 5 min stretching
  • Post-workout meal within 60 min

3.3 Wednesday: Active Recovery & Mobility

Option A: Low-Intensity Steady State (LISS)

  • 30-45 min easy walk, swim, or bike at 50-60% max HR
  • Rationale: Parasympathetic activation, recovery, fat oxidation

Option B: Yoga or Mobility Flow (45-60 min)

  • Focus: Hip mobility, thoracic rotation, shoulder stability
  • Poses: Downward dog, pigeon, cat-cow, child's pose, shoulder pass-throughs
  • Rationale: Flexibility, injury prevention, stress reduction

Option C: Complete Rest

  • Sleep, meal prep, meditation
  • Rationale: CNS recovery, parasympathetic tone

3.4 Thursday: Lower Body Strength + Power

Warm-up (5-10 min):

  • 2 min rowing
  • Leg swings, bodyweight squats, jump rope x 20

Main Work (50-55 min):

ExerciseSets x RepsTempoRestNotes
Deadlift (Conventional or Sumo)4 x 3-52-1-13.5 minHeavy, posterior chain
Front Squat or Goblet Squat3 x 5-82-1-13 minQuad emphasis, core
Bulgarian Split Squat3 x 8 each leg2-1-12 minUnilateral strength
Box Jump or Broad Jump4 x 3-5Explosive3 minPower development
Hamstring Curl3 x 8-102-1-22 minHamstring strength
Sled Push3 x 20 metersExplosive90 secQuad power, metabolic

Power Focus:

  • Emphasize explosiveness on jumps/plyometrics
  • Rationale: Neurological adaptation, muscle fiber recruitment, longevity

Post-Workout:

  • 5 min stretching
  • Post-workout meal within 60 min

3.5 Friday: Upper Body Strength + Hypertrophy

Warm-up (5-10 min):

  • 2 min rowing
  • Band pull-aparts, push-ups, arm circles

Main Work (50-55 min):

ExerciseSets x RepsTempoRestNotes
Deadlift Variation or Weighted Dips4 x 3-62-1-13 minHeavy, chest/tricep/back
Barbell Rows (Pendlay or Yates)4 x 5-82-1-13 minBack strength, thickness
Incline Bench Press3 x 6-82-1-12.5 minUpper chest, anterior shoulder
Lat Pulldown or Pull-ups3 x 8-102-1-12 minBack width
Dumbbell Rows3 x 8-102-1-12 minUnilateral strength
Overhead Press (Barbell or Dumbbell)3 x 6-82-1-12.5 minShoulder strength
Face Pulls3 x 12-151-1-190 secShoulder health, rear delts

Post-Workout:

  • 5 min stretching
  • Post-workout meal within 60 min

3.6 Saturday: HIIT & Conditioning (20-30 min)

Option A: Rowing Machine HIIT

  • Warm-up: 3 min easy
  • Main: 8 rounds of (30 sec max effort + 90 sec easy)
  • Cool-down: 2 min easy

Option B: Bike Sprints

  • Warm-up: 3 min easy
  • Main: 6 rounds of (45 sec max effort + 2 min easy)
  • Cool-down: 2 min easy

Option C: Sled Push/Battle Ropes

  • Warm-up: 2 min easy movement
  • Main: 5 rounds of (30 sec sled push + 30 sec battle ropes + 60 sec rest)

Option D: Running Intervals (if joint-healthy)

  • Warm-up: 5 min easy jog
  • Main: 6-8 x 200-400m at 85-95% max effort, 2 min walk/jog recovery
  • Cool-down: 5 min easy jog

Post-Conditioning:

  • 5-10 min easy movement
  • Post-workout meal within 60 min

3.7 Sunday: Complete Rest or Gentle Movement

  • Sleep, meal prep, meditation
  • Optional: 10-20 min easy walk or gentle stretching
  • Rationale: CNS recovery, parasympathetic tone, injury prevention

Phase 2: Weeks 5-8 (Strength & Power Emphasis)

Objective: Increase neural drive, maximize strength gains, enhance power output

3.8 Monday: Lower Body Strength (Heavy)

ExerciseSets x RepsTempoRestNotes
Back Squat5 x 3-53-1-14 minHeavy strength focus
Deadlift (Variation)3 x 3-52-1-14 minPosterior chain strength
Front Squat3 x 5-82-1-13 minQuad strength, core
Box Jumps4 x 3-5Explosive3 minPower development
Leg Press (Heavy)3 x 5-82-1-12.5 minQuad strength, volume
Sled Push (Heavy)3 x 10-15 metersExplosive2 minPower, quad strength

3.9 Tuesday: Upper Body Strength + HIIT

ExerciseSets x RepsTempoRestNotes
Bench Press5 x 3-53-1-14 minHeavy strength
Barbell Rows5 x 3-52-1-14 minBack strength
Weighted Pull-ups3 x 3-62-1-13 minUpper back, strength
Incline Press3 x 5-82-1-12.5 minUpper chest
Dumbbell Rows3 x 6-82-1-12.5 minUnilateral strength
Overhead Press3 x 5-82-1-12.5 minShoulder strength

HIIT: 8 rounds of (45 sec max effort + 2 min easy) on rowing machine or bike


3.10 Thursday: Lower Body Power & Hypertrophy

ExerciseSets x RepsTempoRestNotes
Front Squat or Goblet Squat4 x 5-82-1-13 minQuad strength, power
RDL3 x 6-82-1-22.5 minHamstring strength
Bulgarian Split Squats3 x 8 each2-1-12 minUnilateral, hypertrophy
Jump Squats4 x 5Explosive3 minPower, explosive strength
Leg Curl3 x 8-122-1-22 minHamstring hypertrophy
Calf Raises3 x 12-201-0-190 secEndurance, calf development

3.11 Friday: Upper Body Power & Hypertrophy

ExerciseSets x RepsTempoRestNotes
Incline Bench Press4 x 5-82-1-13 minUpper chest strength
Weighted Pull-ups4 x 3-62-1-13 minBack strength, power
Dumbbell Bench Press3 x 6-102-1-12 minChest hypertrophy
Barbell Rows (Pendlay)3 x 6-82-1-12.5 minBack thickness
Clap Push-ups or Medicine Ball Chest Pass3 x 5Explosive2 minUpper body power
Dips (Weighted if possible)3 x 6-102-1-12 minChest/tricep strength

Phase 3: Weeks 9-12 (Deload, Periodization, and Peaking)

Objective: Consolidate gains, manage fatigue, test new maxes, prepare for next cycle

3.12 Week 9-10: Maintenance Phase

Lower Body Day:

  • 3 x 5-8 on main lifts (squat, deadlift)
  • 3 x 8-12 on accessory work
  • Reduce volume by ~30% from Phase 2
  • Maintain intensity (RPE 7-8/10)

Upper Body Day:

  • 3 x 5-8 on main lifts (bench, rows)
  • 3 x 8-12 on accessory work
  • Reduce volume by ~30%
  • Maintain intensity

Conditioning:

  • 2x per week at moderate intensity (60-70% max effort)

3.13 Week 11-12: Testing & Peaking

Monday: Lower Body Strength Test

  • Warm-up: Gradual build-up
  • Main: Attempt new 3-5 rep max on squat
  • Follow-up: 3 x 8 at 80% of new max
  • Accessory: 2 x 8-10 on secondary lifts

Tuesday: Upper Body Strength Test

  • Warm-up: Gradual build-up
  • Main: Attempt new 3-5 rep max on bench or rows
  • Follow-up: 3 x 8 at 80% of new max
  • Accessory: 2 x 8-10 on secondary lifts

Thursday & Friday: Moderate intensity work (RPE 6-7/10)

Conditioning: 1x per week at high intensity


General Strength Training Principles

RPE Scale (Rate of Perceived Exertion):

  • RPE 6: Could do 4+ more reps
  • RPE 7: Could do 3 more reps
  • RPE 8: Could do 2 more reps
  • RPE 9: Could do 1 more rep
  • RPE 10: Maximum effort, no reps left

Tempo Notation (e.g., 3-1-1):

  • First number: Eccentric (lowering) phase in seconds
  • Second number: Pause at bottom
  • Third number: Concentric (lifting) phase in seconds

Progressive Overload Strategy:

  • Week 1: Establish baseline with target weight/reps
  • Week 2: Add 1-2 reps or 5 lbs
  • Week 3: Add 1-2 reps or 5 lbs
  • Week 4: Deload (reduce volume 30-40%)
  • Repeat

Accessory Exercise Library

Lower Body:

  • Leg Press, Hack Squat, V-Squat
  • Leg Curl, Lying Leg Curl
  • Calf Raises, Seated Calf Raises
  • Sled Push, Sled Drag
  • Hack Squat, Smith Machine Squat
  • Step-ups, Bulgarian Split Squats

Upper Body:

  • Dumbbell Press, Machine Press
  • Lat Pulldown, Assisted Pull-ups
  • Dumbbell Flyes, Machine Flyes
  • Face Pulls, Reverse Flyes
  • Barbell Curls, Dumbbell Curls, Machine Curls
  • Tricep Dips, Rope Pushdowns, Skull Crushers
  • Lateral Raises, Front Raises, Upright Rows
  • Shrugs, Farmer Carries

PART 4: RECOVERY & SLEEP OPTIMIZATION

4.1 Sleep Architecture Optimization

Objective: Achieve 7-9 hours of high-quality sleep nightly, with emphasis on deep sleep and REM

Sleep Hygiene Protocol

Evening Routine (7-10pm):

  1. Light Reduction (8pm):

    • Dim lights to <50 lux
    • Use blue-light blocking glasses (Swannies, Spektrums)
    • No screens after 9pm (or use f.lux, Night Shift)
  2. Temperature Control (9pm):

    • Bedroom temperature: 60-67°F (15.5-19.5°C)
    • Consider cooling mattress (OOLER, ChiliSleep, Helix)
    • Cool shower or ice bath (optional, see below)
  3. Supplement Timing (9-9:30pm):

    • Magnesium Glycinate 300-500mg
    • L-Glycine 3-5g
    • Apigenin 50-100mg
    • Ashwagandha 300-600mg
    • Melatonin 0.5-5mg (5 nights/week only)
  4. Behavioral Practices (8-10pm):

    • No caffeine after 2pm
    • No large meals after 7pm
    • Dim lighting, relaxing music
    • Meditation or breathwork (10-20 min)
    • Journaling or gratitude practice (5-10 min)
    • Light reading (non-stimulating)
  5. Bedroom Environment:

    • Complete darkness (blackout curtains, eye mask)
    • White noise machine (brown noise preferred) or earplugs
    • No phones/screens (if needed, distance >3 feet)
    • Air purifier (optional)
    • Humidifier (if dry climate)

Sleep Tracking & Monitoring

Wearables for Sleep Tracking:

  • Oura Ring: HRV, temperature, sleep stages (gold standard)
  • WHOOP Band: Sleep, strain, recovery
  • Apple Watch: Basic sleep tracking
  • Garmin: Sleep stages, HRV
  • Eight Sleep: Smart mattress with temperature control + tracking

Target Metrics:

  • Total Sleep: 7-9 hours
  • Deep Sleep: 1.5-2.5 hours (20-30% of total)
  • REM Sleep: 1.5-2 hours (20-25% of total)
  • Sleep Efficiency: >85% (time asleep / time in bed)
  • Resting Heart Rate: <60 bpm (lower = better recovery)
  • HRV: >50 ms (higher = better parasympathetic tone)

4.2 Stress Management & HRV Training

Objective: Improve parasympathetic tone, reduce cortisol, enhance recovery

Heart Rate Variability (HRV) Training

What is HRV?

  • Measure of variation in time between heartbeats
  • Higher HRV = better parasympathetic (vagal) tone
  • Indicator of recovery, stress resilience, longevity

HRV Tracking Apps:

  • HRV4Training (gold standard)
  • Whoop
  • Elite HRV
  • Oura Ring
  • Apple Health + third-party apps

HRV-Based Training Adjustments:

HRV StatusActionRationale
High (>90th percentile)Hard training, strength focusGood recovery, CNS ready
Normal (40-90th percentile)Moderate training, mixedBalanced training
Low (<40th percentile)Light training, recovery focusPoor recovery, CNS fatigued

Protocol:

  • Measure HRV first thing in morning (before getting out of bed)
  • Take 5-minute reading in HRV app
  • Adjust daily training intensity based on score
  • Track trends over weeks/months

Breathing & Parasympathetic Activation

4-7-8 Breathing (Wim Hof-inspired):

  • Inhale for 4 counts
  • Hold for 7 counts
  • Exhale for 8 counts
  • 4 rounds, 2x daily (morning + evening)
  • Rationale: Activates vagus nerve, reduces cortisol

Box Breathing (for acute stress):

  • Inhale 4 counts
  • Hold 4 counts
  • Exhale 4 counts
  • Hold 4 counts
  • 5-10 rounds as needed
  • Rationale: Balances nervous system

Nasal Breathing:

  • Practice nasal breathing during day and sleep
  • Improves oxygenation, reduces mouth breathing
  • Use Somnifix or similar mouth tape at night (optional)

Cold Exposure & Stress Resilience

Wim Hof Method (Optional, Advanced):

  • 10-15 min cold shower (50-60°F) 2-3x per week
  • Or ice bath (50-55°F) for 3-5 min
  • Rationale: Activates parasympathetic rebound, improves stress resilience, anti-inflammatory

Protocol:

  • Weeks 1-4: Cold shower finishes (30-60 sec cold at end of hot shower)
  • Weeks 5-8: Cold showers (2-3 min) 2x per week
  • Weeks 9-12: Cold showers (3-5 min) 2-3x per week or ice bath (3-5 min) 1x per week

Contraindications:

  • Avoid if pregnant, hypertensive, or cardiac history
  • Not immediately post-workout (delays recovery)
  • Not immediately before bed

Meditation & Mindfulness

Daily Meditation Protocol:

  • Morning (5-10 min): Focused attention or loving-kindness meditation
  • Evening (10-20 min): Body scan or progressive relaxation
  • Apps: Headspace, Calm, Insight Timer, Ten Percent Happier

Neurofeedback (Optional, Advanced):

  • Muse Headband: Real-time brainwave feedback for meditation
  • Provides auditory cues based on alpha/theta waves
  • 10 min daily for enhanced parasympathetic activation

4.3 Sauna & Heat Therapy

Benefits:

  • Increased growth hormone (up to 140% in some studies)
  • Heat shock proteins (cellular protection)
  • Cardiovascular adaptation
  • Stress resilience
  • Muscle recovery

Protocol:

  • Frequency: 2-3x per week
  • Duration: 15-30 min per session
  • Temperature: 160-180°F (70-82°C) for dry sauna, 110-130°F (43-54°C) for infrared
  • Post-sauna: Cool down naturally or cold water rinse
  • Hydration: 500-1000ml electrolyte solution during/after

Timing:

  • Post-workout: 30-60 min after, not immediately
  • Evening: 2-3 hours before bed
  • Not immediately post-meal

4.4 Massage & Myofascial Release

Weekly Routine:

  • Professional massage: 1x per month (60 min)
  • Self-myofascial release: 10-15 min daily

Tools:

  • Foam roller (standard, trigger point, vibrating)
  • Lacrosse ball or trigger point ball
  • Massage gun (Theragun, Hypervolt)
  • Percussion massager

Daily Self-Release Protocol (10-15 min):

  • Calves: 2 min per leg (foam roller)
  • Quads: 2 min per leg (foam roller)
  • IT Band: 2 min per side (foam roller, trigger point)
  • Upper back: 2 min (foam roller)
  • Chest: 1 min per side (lacrosse ball)
  • Shoulders: 1 min per side (lacrosse ball)

4.5 Active Recovery Days

Purpose: Enhance blood flow, reduce soreness, maintain aerobic capacity without CNS fatigue

Option A: Light Cardio (30-45 min)

  • Easy walk (Zone 1: 50-60% max HR)
  • Easy bike or swim
  • Conversational pace

Option B: Yoga or Mobility Flow (45-60 min)

  • Focus on hip, shoulder, thoracic mobility
  • Gentle stretching
  • Parasympathetic activation

Option C: Tai Chi or Qigong (30-45 min)

  • Slow, flowing movements
  • Breathing focus
  • Stress reduction

Guidelines:

  • Heart rate: <120 bpm for most of session
  • Perceived exertion: 2-3/10
  • No metabolic stress
  • Can do daily if needed

PART 5: STRESS RESILIENCE & COGNITIVE ENHANCEMENT

5.1 Stress Resilience Framework

Baseline Stress Assessment

Measure at Week 1, 6, 12:

  • Perceived Stress Scale (PSS-10)
  • Cortisol levels (salivary or serum)
  • Resting heart rate
  • HRV trends
  • Sleep quality
  • Mood/anxiety scales

Cognitive Behavioral Techniques

Stress Inoculation Training:

  • Identify major stressors
  • Practice controlled exposure
  • Build confidence in stress management
  • Gradually increase difficulty

Example Protocol (Weeks 1-12):

  • Week 1-2: Identify 3 major stressors
  • Week 3-4: Practice 1-2 min exposure to mild stressor
  • Week 5-8: Increase exposure duration to 5-10 min
  • Week 9-12: Add multiple stressors simultaneously

Neurofeedback Concepts

Muse Headband Protocol (Optional):

  • Real-time EEG feedback for meditation
  • Trains alpha waves (relaxation) and theta waves (deep focus)
  • 10 min daily sessions
  • Gamified feedback (birds, weather)

Neurofeedback Goals:

  • Increase alpha power (8-12 Hz) for relaxation
  • Increase theta power (4-8 Hz) for focus
  • Decrease high-frequency beta (>20 Hz) for anxiety reduction

5.2 Cognitive Enhancement Protocols

Working Memory & Focus Training

Dual N-Back Task (Brain Training):

  • Free app: Brain Workshop, Dual N-Back
  • 20 min daily, 5 days per week
  • Increases working memory and fluid intelligence
  • Weeks 1-12: Progressive difficulty increase

Protocol:

  • Week 1-2: N-Back 2 (easy)
  • Week 3-4: N-Back 2-3 (moderate)
  • Week 5-8: N-Back 3-4 (hard)
  • Week 9-12: N-Back 4+ (very hard)

Cognitive Testing & Monitoring

NIH Toolbox Cognitive Battery:

  • Free online cognitive assessment
  • Tests: Processing speed, attention, memory, executive function
  • Baseline + Week 12 comparison

Lumosity or Peak Brain Training:

  • Gamified cognitive training
  • Daily 15-30 min sessions
  • Tracks improvement over time

Learning & Neuroplasticity Activation

Novel Learning Protocol (Pick One):

  • Learn a new language (Duolingo, 15 min daily)
  • Learn a musical instrument (30 min daily)
  • Learn a new skill (coding, art, etc.)
  • Rationale: Novel learning activates BDNF, neuroplasticity

Reading Protocol:

  • 30-60 min daily of non-fiction or challenging material
  • Focus areas: Longevity science, neuroscience, philosophy
  • Rationale: Cognitive engagement, vocabulary expansion

5.3 Social Connection & Meaning

Rationale: Strong social connections predict longevity better than most biomarkers

Weekly Protocol:

  • In-person: 1-2 meaningful conversations or social activities (60+ min)
  • Community: 1-2 hours per week in group activity (fitness class, club, volunteer)
  • Family: 30-60 min quality time with loved ones
  • Gratitude: Daily gratitude practice or journaling (5-10 min)
  • Meaning: Identify 1-2 activities that align with personal values

PART 6: TRACKING & BIOFEEDBACK SYSTEM

6.1 Wearable Devices & Apps

Primary Wearables

DeviceMetricsFrequencyCost
Oura Ring (Gen 3)Sleep, HRV, temperature, activityDaily$300-400
WHOOP BandSleep, strain, recovery, HRVDaily$30/month
Garmin Fenix/EpixSleep, HRV, training load, VO2 maxDaily$600-900
Apple Watch UltraActivity, workouts, ECG, blood oxygenDaily$800
Continuous Glucose Monitor (Dexcom)Blood glucoseEvery 5 min$50-150/month

Recommended Stack (Budget-Conscious)

Tier 1 (Essential):

  • Oura Ring or WHOOP (sleep, HRV, recovery)
  • Garmin or Apple Watch (activity, workouts)
  • Continuous Glucose Monitor (optional but valuable)

Tier 2 (Advanced):

  • Add: Muse Headband (neurofeedback)
  • Add: Eight Sleep (smart mattress with temperature control)

6.2 Biomarker Tracking Protocol

Blood Testing Schedule

Baseline (Week 1):

  • Lipid panel (Total cholesterol, LDL, HDL, Triglycerides)
  • Fasting glucose
  • Insulin
  • HbA1c
  • hs-CRP (inflammation)
  • Homocysteine
  • Testosterone, DHEA-S
  • Thyroid (TSH, Free T3, Free T4)
  • Vitamin D (25-OH)
  • Vitamin B12, folate
  • Complete metabolic panel (liver, kidney function)
  • Complete blood count

Mid-Point (Week 6, Optional):

  • Vitamin D, B12, homocysteine (if concerned)
  • Glucose, insulin (if tracking CGM)

End-Point (Week 12):

  • Repeat full baseline panel
  • Compare to baseline

Providers:

  • Quest Diagnostics, LabCorp (standard)
  • Ulta Lab Tests, Any Lab Test Now (direct-to-consumer)
  • Thorne, EverlyWell (at-home kits)
  • Functional medicine doctors (more comprehensive)

Tracking Spreadsheet Template

Create Google Sheet with tabs:

Tab 1: Daily Metrics

DateSleep (h)HRV (ms)RHR (bpm)WorkoutMood (1-10)Stress (1-10)Notes
1/17.56558Lower83

Tab 2: Weekly Averages

WeekAvg SleepAvg HRVAvg RHRWorkoutsAvg MoodAvg Stress

Tab 3: Blood Work

DateGlucoseInsulinHDLLDLTriglycerideshs-CRPTestosteroneVitamin D

Tab 4: Body Composition

DateWeight (lb)Muscle (lb)Fat (%)Waist (in)

Tab 4: Performance

DateSquat 1RMBench 1RMDeadlift 1RMVO2 MaxGrip Strength

6.3 Monthly Review Protocol

First Sunday of Each Month (30-45 min):

  1. Data Review (10 min):

    • Compile all metrics from past month
    • Calculate averages
    • Identify trends (improving, declining, stable)
  2. Assessment (10 min):

    • What went well?
    • What was challenging?
    • What needs adjustment?
  3. Biomarker Analysis (5 min):

    • Any concerning trends?
    • Supplement effectiveness?
    • Dietary adjustments needed?
  4. Training Analysis (5 min):

    • Strength progress?
    • Conditioning improvements?
    • Injury concerns?
  5. Adjustments (10 min):

    • Modify supplements if needed
    • Adjust training based on performance
    • Refine diet based on CGM/weight trends
    • Update goals

PART 7: IMPLEMENTATION TIMELINE

Week 1: Assessment & Setup Phase

Days 1-3:

  • Schedule baseline blood work (get results by end of week)
  • Establish baseline metrics (weight, body composition, grip strength, VO2 max)
  • Set up wearables (Oura, WHOOP, Garmin, CGM if using)
  • Download tracking apps (HRV4Training, MyFitnessPal, Cronometer)
  • Create Google Sheet for tracking

Days 4-7:

  • Begin baseline diet (no elimination yet, just track)
  • Start morning routine (meditation, HRV reading)
  • Begin evening routine (sleep hygiene)
  • Start Tier 1 supplements (micronutrients, mitochondrial support)
  • Begin training Week 1 protocol
  • Establish fasting window (11am-7pm)

End of Week 1:

  • Review blood work results
  • Adjust supplements based on deficiencies
  • Confirm training program is sustainable
  • Assess sleep quality (first night data)

Week 2-4: Metabolic Reset & Baseline

Focus: Establish consistent habits, baseline performance

Daily:

  • Track all meals (MyFitnessPal or Cronometer)
  • Read HRV upon waking
  • Complete scheduled workout
  • Evening routine (sleep hygiene, supplements)
  • Track sleep metrics

Weekly:

  • Monday: Review previous week's data
  • Adjust macros if needed based on body composition changes
  • Assess training progress (weights, reps, RPE)
  • Meditation: 5-10 min daily

Supplements (Tier 1 + 2):

  • Micronutrients (daily)
  • Mitochondrial support (daily)
  • Antioxidants (daily)
  • Cognitive stack (daily)
  • Sleep stack (5 nights/week)

Training:

  • Weeks 1-4 program (hypertrophy focus)
  • 4 strength days + 2 conditioning + 1 rest

Dietary Adjustments:

  • Eliminate seed oils, processed foods
  • Increase whole foods
  • Establish 8-hour eating window

Week 5-8: Metabolic Flexibility & Strength Building

Focus: Transition to keto-refeed cycling, increase strength focus

Days 1-3:

  • Begin 4-day keto / 3-day refeed cycle
  • Adjust macros: Keto days <30g carbs, refeed days 1.5-2g/lb carbs
  • Recalculate caloric targets
  • Update MyFitnessPal

Supplements (Add to Tier 1 & 2):

  • Longevity stack: Fisetin, Spermidine, NMN
  • Advanced cognitive: All cognitive stack
  • Recovery stack: All recovery supplements
  • Fat loss stack (if doing HIIT): Green tea, L-carnitine, Yohimbine

Training:

  • Weeks 5-8 program (strength & power emphasis)
  • Increase intensity on main lifts
  • Add power work (box jumps, plyometrics)

Recovery:

  • Add sauna 2x per week (15-20 min)
  • Add cold showers 2x per week (2-3 min)
  • Increase meditation to 10-15 min daily
  • HRV-based training adjustments

Testing (Week 6):

  • Optional: Recheck Vitamin D, B12, glucose (if using CGM)
  • Assess strength progress (attempt new maxes)
  • Body composition check (if doing DEXA)

Week 9-12: Peaking & Testing

Focus: Consolidate gains, test new maxes, prepare for next cycle

Weeks 9-10: Maintenance Phase

  • Reduce training volume by 30%
  • Maintain intensity (RPE 7-8/10)
  • Continue all supplements
  • Continue keto-refeed cycling

Weeks 11-12: Testing & Peaking

  • Attempt new 1RM on main lifts
  • Reduce conditioning volume
  • Maintain mobility work
  • Continue all supplements

Week 12: Final Testing & Assessment

  • Schedule final blood work (same tests as baseline)
  • Final body composition (DEXA, InBody)
  • VO2 max test
  • Cognitive testing (NIH Toolbox or Lumosity)
  • Grip strength
  • Compare all metrics to baseline

Week 12: Review & Plan Next Cycle

  • Comprehensive data review (all metrics)
  • Identify biggest improvements
  • Identify areas needing work
  • Plan next 12-week cycle (variations, new goals)
  • Update supplement stack based on results

PART 8: MONTHLY PROGRESSION & ADJUSTMENTS

Month 1 (Weeks 1-4): Establishing Baseline

Primary Goal: Establish habits, collect baseline data

Expected Changes:

  • Slight weight loss (1-3 lbs) from reduced processed foods
  • Improved sleep quality (especially weeks 3-4)
  • Increased energy (weeks 2-3, possible energy dip week 1)
  • Improved digestion, reduced bloating

Adjustments if Needed:

  • If weight loss too rapid (>3 lbs/week): Increase calories by 200-300
  • If weight gain (>2 lbs/week): Reduce calories by 200-300
  • If sleep poor: Increase magnesium, reduce evening caffeine cutoff to 12pm
  • If energy low: Check sleep, increase carbs on training days

Month 2 (Weeks 5-8): Metabolic Adaptation & Strength Building

Primary Goal: Increase strength, establish metabolic flexibility

Expected Changes:

  • Continued fat loss (1-2 lbs/week if in deficit)
  • Significant strength gains (5-15% increase in main lifts)
  • Improved body composition (muscle gain, fat loss)
  • Better energy on refeed days
  • Improved workout performance

Adjustments if Needed:

  • If strength plateau: Increase volume, add power work, ensure adequate sleep
  • If fatigue: Increase carbs on refeed days, reduce HIIT frequency
  • If muscle loss: Increase protein to 1.2g/lb, add more refeed days
  • If fat loss stalled: Increase HIIT frequency, reduce calories slightly, add L-carnitine

Month 3 (Weeks 9-12): Consolidation & Testing

Primary Goal: Test improvements, prepare for next cycle

Expected Changes:

  • Significant strength gains (10-20% from baseline)
  • Improved body composition (5-15 lb fat loss if in deficit, 5-10 lb muscle gain)
  • Enhanced cognitive performance (NIH Toolbox scores)
  • Improved blood markers (lipids, glucose, inflammation)
  • Better sleep quality, higher HRV

Adjustments if Needed:

  • If overtraining symptoms: Reduce volume, increase rest days
  • If blood markers poor: Adjust diet (increase antioxidants, reduce refined carbs)
  • If cognitive gains minimal: Increase brain training, add novel learning

PART 9: TROUBLESHOOTING & ADAPTATION

Common Issues & Solutions

Issue 1: Weight Loss Stalled (Weeks 5-8)

Possible Causes:

  • Metabolic adaptation
  • Overeating on refeed days
  • Insufficient cardio
  • Sleep deprivation
  • Stress/cortisol elevation

Solutions:

  • Reduce calories by 200-300
  • Increase HIIT frequency (add 3rd session)
  • Reduce refeed carbs slightly (1-1.5g/lb instead of 1.5-2g/lb)
  • Increase L-carnitine, add Yohimbine
  • Prioritize sleep (add melatonin, reduce stress)
  • Check cortisol levels (salivary test)

Issue 2: Strength Plateau

Possible Causes:

  • Insufficient caloric intake
  • Inadequate protein
  • Poor sleep/recovery
  • Overtraining (high HIIT frequency)
  • Poor form/technique

Solutions:

  • Increase calories by 200-300 (especially on strength days)
  • Ensure 1.2g/lb protein
  • Add extra rest day or reduce HIIT to 1x/week
  • Film sets, check form with coach
  • Add more refeed days (increase to 4 refeed days)
  • Reduce supplement cycling (ensure consistent dosing)

Issue 3: Poor Sleep Quality

Possible Causes:

  • Blue light exposure
  • Caffeine timing
  • Stress/anxiety
  • Magnesium deficiency
  • Sleep apnea

Solutions:

  • Strict blue light avoidance after 8pm
  • Caffeine cutoff at 2pm (or eliminate)
  • Add meditation (10-20 min evening)
  • Increase magnesium to 500-600mg
  • Add Valerian, Passionflower
  • Sleep apnea test (home test or sleep study)
  • Consider sleep coaching (Oura, Whoop provide recommendations)

Issue 4: Digestive Issues

Possible Causes:

  • Rapid diet change
  • Insufficient fiber (on keto days)
  • Dairy intolerance
  • Food sensitivities

Solutions:

  • Slow dietary transition (don't eliminate all foods at once)
  • Increase fiber on refeed days (vegetables, rice)
  • Eliminate dairy for 2 weeks, then reintroduce
  • Add fermented foods (sauerkraut, kimchi, kefir)
  • Add digestive enzymes (Betaine HCL, Bromelain)
  • Consider elimination diet (low-FODMAP, AIP)

Issue 5: Supplement Side Effects

Common Issues:

  • Nausea: Reduce supplement dose, take with food, switch brands
  • Headaches: Often NAC or high-dose antioxidants; reduce dose
  • Sleep disruption: Check timing of stimulating supplements (caffeine, L-Tyrosine, Rhodiola)
  • GI upset: Creatine, Beta-Alanine; take with food, increase water
  • Jitteriness: Reduce caffeine, L-Theanine, or Yohimbine

Solutions:

  • Reduce doses by 50%, slowly increase
  • Change timing (take with different meal)
  • Switch brands or forms
  • Take 1-2 week break, reintroduce

Issue 6: Overtraining/CNS Fatigue

Symptoms:

  • Declining strength despite good effort
  • Elevated resting heart rate (>10 bpm above baseline)
  • Low HRV
  • Irritability, mood disturbance
  • Poor sleep
  • Increased injury risk

Solutions:

  • Immediate: Reduce training volume by 30-50%
  • Take 3-5 day complete rest
  • Increase sleep (aim for 9-10 hours)
  • Reduce HIIT frequency
  • Increase recovery tools (sauna, massage, cold exposure)
  • Check HRV daily, train only if HRV normal

Personalization Adjustments

Based on Genetic Testing (If Available)

MTHFR Variants:

  • If homozygous or heterozygous: Use methylated B vitamins (methylfolate, methylcobalamin)
  • Increase folate intake

ApoE Variants:

  • ApoE3/3 (most common): Standard protocol
  • ApoE3/4 or 4/4: May need lower carb diet, focus on antioxidants, may have higher cholesterol response to saturated fat

Caffeine Sensitivity (CYP1A2):

  • Fast metabolizer: Can tolerate daily caffeine
  • Slow metabolizer: Reduce caffeine frequency, earlier cutoff time

Based on Metabolic Type

Protein Type (Fast Oxidizers):

  • Higher protein (1.2-1.4g/lb)
  • Lower carbs (0.5-1g/lb)
  • Higher fat (0.8-1.2g/lb)
  • More frequent meals (4-5/day)

Carb Type (Slow Oxidizers):

  • Moderate protein (0.8-1g/lb)
  • Higher carbs (1-1.5g/lb)
  • Lower fat (0.5-0.8g/lb)
  • Fewer, larger meals (2-3/day)

Balanced Type:

  • Moderate protein (1-1.1g/lb)
  • Moderate carbs (0.8-1g/lb)
  • Moderate fat (0.7-0.9g/lb)
  • Moderate meal frequency (3-4/day)

Based on Training Response

Poor Responder to Strength Training:

  • Increase volume (more sets/reps)
  • Increase frequency (5-6 days/week)
  • Increase calories (maintenance to +300)
  • Add more refeed days
  • Ensure >8 hours sleep

Good Responder to Strength Training:

  • Standard protocol
  • May progress faster through phases

Poor Responder to Cardio:

  • Increase HIIT frequency (3x/week)
  • Add longer steady-state sessions (45-60 min)
  • Increase L-carnitine, Green tea extract
  • Check VO2 max trajectory

PART 10: LONG-TERM SUSTAINABILITY & NEXT CYCLES

Post-12-Week Assessment

Comprehensive Review (Week 12):

  1. Quantitative Improvements:

    • Compare all blood markers (lipids, glucose, inflammation, hormones)
    • Body composition changes
    • Strength gains
    • Cardiovascular improvements (VO2 max)
    • Cognitive performance
  2. Qualitative Assessment:

    • Energy levels
    • Sleep quality
    • Mood/mental health
    • Stress resilience
    • Overall well-being
  3. Adherence & Sustainability:

    • Which habits stuck?
    • Which were challenging?
    • What needs modification for long-term?

Next 12-Week Cycle (Weeks 13-24)

Option A: Repeat with Variations

  • Maintain successful protocols
  • Increase training intensity/volume
  • Rotate exercise selection
  • Adjust supplement stack based on results

Option B: Different Focus

  • Weeks 13-24: Muscle building emphasis (higher calories, more volume)
  • Weeks 25-36: Strength & power focus
  • Weeks 37-48: Fat loss & conditioning focus

Option C: Advanced Biohacking

  • Add rapamycin (if medically supervised)
  • Try senolytic protocols (Fisetin + Quercetin)
  • Add exosome therapy (if available)
  • Experiment with plasma exchange

Maintenance Protocol (Year 2+)

Once established, simplified protocol:

Training:

  • 3-4 strength days/week (lower volume than initial 12 weeks)
  • 1-2 conditioning days/week
  • 2-3 active recovery days

Nutrition:

  • Maintenance calories (no aggressive deficit/surplus)
  • Flexible macro cycling (no strict keto-refeed)
  • Intuitive eating with protein priority

Supplements:

  • Tier 1 (micronutrients) + Tier 2 (mitochondrial) + Tier 3 (targeted)
  • Reduce frequency of advanced stacks
  • Annual senolytic protocol (2 weeks)

Recovery:

  • 7-9 hours sleep nightly
  • Sauna 1x/week
  • Cold exposure 1x/week
  • Meditation 5-10 min daily
  • Monthly massage or myofascial release

Testing:

  • Annual blood work (same panel as baseline)
  • Annual body composition
  • Annual VO2 max, strength testing
  • Quarterly HRV tracking

APPENDIX: QUICK REFERENCE GUIDES

Daily Supplement Stack (Simplified)

Morning (with breakfast):

  • Vitamin D3 4,000 IU
  • Magnesium Glycinate 400mg
  • Omega-3 (fish oil) 2-3g EPA/DHA
  • CoQ10 (Ubiquinol) 200mg
  • Alpha-GPC 600mg
  • Caffeine 100-200mg (or L-Theanine 100mg)
  • Lion's Mane 500mg
  • Curcumin 500mg + Piperine 5mg
  • Creatine 5g

Mid-Day (around lunch):

  • Bacopa Monnieri 300mg
  • Ginkgo Biloba 120mg
  • Quercetin 500mg
  • Astaxanthin 4-12mg
  • NAC 600mg

Pre-Workout (30-60 min before):

  • Citrulline Malate 6-8g
  • Beta-Alanine 3-5g
  • L-Carnitine 2-3g (if fat loss focus)

Post-Workout (within 60 min):

  • Creatine 5g (with carbs + protein)
  • Collagen 10-20g
  • Bromelain 500-1,000 GDU

Evening (with dinner):

  • Omega-3 (fish oil) 2-3g EPA/DHA
  • Magnesium Glycinate 300-400mg
  • Boswellia 300-500mg
  • Vitamin K2 90-180mcg

Before Bed (30-60 min):

  • Magnesium Glycinate 300-500mg
  • L-Glycine 3-5g
  • Apigenin 50-100mg
  • Ashwagandha 300-600mg
  • Melatonin 0.5-5mg (5x/week)

Weekly Meal Template

Keto Days (Mon, Tue, Thu, Fri):

MealExample
Breakfast (11am)8oz salmon + 2 tbsp MCT oil + 3 cups spinach
Lunch (3pm)6oz grass-fed beef + 2 tbsp ghee + salad
Dinner (6:30pm)8oz pastured chicken + 1/4 cup macadamia nuts + broccoli

Refeed Days (Wed, Sat, Sun):

MealExample
Breakfast (11am)8oz beef + 1.5 cups white rice + vegetables
Lunch (3pm)6oz chicken + 1.5 cups white rice + honey
Dinner (6:30pm)8oz salmon + 1 cup sweet potato + vegetables

Weekly Training Template

DayFocusDurationIntensity
MonLower Strength50 minRPE 8-9
TueUpper Strength + HIIT65 minRPE 8-9 + 9
WedActive Recovery30-45 minRPE 3-4
ThuLower Power50 minRPE 8-9
FriUpper Strength50 minRPE 8-9
SatHIIT Conditioning20-30 minRPE 9
SunRest——

HRV-Based Training Adjustments

HRV StatusTraining Recommendation
>90th percentileHard training, new maxes, high volume
70-90th percentileModerate-heavy training, normal volume
50-70th percentileModerate training, reduced volume
<50th percentileLight training, mobility, recovery focus

Sleep Optimization Checklist

  • Bedroom temperature 60-67°F
  • Complete darkness (blackout curtains)
  • White/brown noise
  • No screens 1 hour before bed
  • Blue light glasses after 8pm
  • Magnesium Glycinate 300-500mg at 9pm
  • L-Glycine 3-5g at 9pm
  • Apigenin 50-100mg at 9pm
  • Melatonin 0.5-5mg at 9:30pm (5x/week)
  • No caffeine after 2pm
  • No large meals after 7pm
  • 10-20 min meditation/breathing before bed

Monthly Tracking Checklist

  • Compile sleep data (average, deep sleep %, REM %)
  • Compile HRV data (average, trend)
  • Compile workout data (lifts, reps, RPE, conditioning)
  • Compile body weight (average, trend)
  • Compile meal tracking (macro averages, adherence)
  • Compile mood/stress scores
  • Review supplement adherence
  • Assess energy levels, recovery
  • Plan adjustments for next month

CONCLUSION

This 3-month longevity plan provides a comprehensive framework for optimizing physical performance, cognitive function, and long-term health. Success requires:

  1. Consistency: Small, consistent actions compound over time
  2. Flexibility: Adjust based on individual response and data
  3. Patience: Significant changes take 8-12 weeks to manifest
  4. Tracking: Data-driven decisions lead to better outcomes
  5. Sustainability: Choose habits you can maintain long-term

Expected Outcomes (Week 12):

  • 5-15 lb body recomposition (fat loss + muscle gain)
  • 10-20% strength improvement
  • 10-20% cardiovascular improvement
  • Improved blood markers (lipids, glucose, inflammation)
  • Better sleep quality, higher HRV
  • Enhanced cognitive performance
  • Improved stress resilience
  • Greater overall well-being

Remember: This is a starting framework. Personalize based on your genetics, response, goals, and lifestyle. Work with qualified healthcare providers (functional medicine doctors, longevity specialists) for medical oversight, especially with advanced interventions like rapamycin or senolytic protocols.

The goal is not perfection, but progressive improvement toward optimal health and longevity.

Advanced Longevity Plan (Biohacker)

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About Claude Haiku 4.5

Capabilities

ConversationReasoningCode GenerationAnalysisTool Use

Categories

TextCodeMultimodal

Specifications

Provider
Anthropic
Released
2025-10-15
Size
LARGE
Context
200,000 tokens

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