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Back to Z.AI: GLM 4.6

Advanced Longevity Plan (Biohacker)

Glm 4 6's response to the 'Advanced Longevity Plan (Biohacker)' challenge.

Z.AI: GLM 4.6
February 4, 2026
Text

?
Prompt

Develop a comprehensive, cutting-edge 3-month longevity plan for a biohacker aiming to optimize longevity, physical and cognitive performance. Incorporate advanced strategies like specific supplement stacks (with dosages and cycling), detailed dietary protocols (e.g., ketogenic variations, fasting regimens), advanced wearable tracking, personalized exercise routines (including strength, HIIT, and recovery), stress resilience techniques (e.g., HRV training, neurofeedback concepts), among other things. The plan should be highly detailed and actionable.

Z.AI: GLM 4.6
Response

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Z.AI: GLM 4.6Advanced Longevity Plan (Biohacker)
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Z.AI: GLM 4.6

Of course. Here is a comprehensive, cutting-edge 3-month longevity plan designed for a dedicated biohacker. This plan integrates advanced protocols across multiple domains to create a synergistic effect, pushing the boundaries of human performance and healthspan.


Disclaimer: For Informational Purposes Only

This plan is a theoretical framework based on current scientific literature and biohacking principles. It is NOT medical advice. Before starting any new supplement, diet, or exercise regimen, especially one this intensive, you must consult with a qualified medical doctor and, ideally, a functional medicine practitioner. Regular blood work is essential to monitor your biomarkers and ensure safety. Listen to your body; adjust as needed.


Guiding Philosophy: Systems Synergy & Hormesis

This plan is built on two core principles:

  1. Systems Synergy: No single intervention works in a vacuum. The power lies in how diet, exercise, sleep, and stress management amplify each other.
  2. Hormesis: The concept of "what doesn't kill you makes you stronger." We will strategically apply controlled stressors (exercise, fasting, cold exposure) to trigger adaptive responses that build resilience and promote cellular cleanup (autophagy).

Phase 1: Foundational Optimization & Baseline (Month 1)

Goal: Establish a rock-solid foundation. Gather baseline data, detoxify, and prime the body's systems for more intense interventions.

1. Advanced Wearable Tracking & Data Collection

Your goal is to become a master of your own data.

  • Core Wearables:
    • Oura Ring or WHOOP: For continuous sleep staging, HRV (Heart Rate Variability), resting heart rate (RHR), and recovery tracking. This is your primary feedback loop.
    • Continuous Glucose Monitor (CGM) (e.g., Freestyle Libre, Levels): To understand your personal glycemic response to foods, exercise, and stress. This is non-negotiable for dietary optimization.
    • Oura Ring / Apple Watch: For SpO2 (blood oxygen) monitoring during sleep and breathwork.
  • Action:
    • Week 1: Wear all devices consistently. Do not change anything yet. Your job is to collect a clean baseline of your current lifestyle.
    • Log Everything: Use an app like Cronometer for precise food tracking and a journal for notes on energy, mood, and cognitive performance.
    • Key Metrics to Watch: Average nightly deep sleep & REM sleep, HRV trends (morning vs. evening), RHR, daily active calories, and your glucose variability score.

2. Dietary Protocol: Ketogenic Reset & Nutrient Density

  • Objective: Achieve metabolic flexibility by becoming a fat-burning machine and reducing systemic inflammation.
  • Protocol: Strict Ketogenic Diet.
    • Macros: ~70-75% Fat, ~20-25% Protein, ~5-10% Net Carbs (<30g/day).
    • Fat Sources: Avocados, extra virgin olive oil, MCT oil, grass-fed butter/ghee, nuts (macadamias, pecans), fatty fish (salmon, sardines).
    • Protein Sources: Prioritize fatty fish, grass-fed beef, pasture-raised eggs, and collagen peptides.
    • Carb Sources: Above-ground vegetables (leafy greens, broccoli, cauliflower, asparagus, zucchini).
    • CGM Integration: Use your CGM to identify which "keto-friendly" foods spike your glucose. Some people react poorly to dairy or certain nuts. Eliminate them.
  • Meal Timing: Start with a standard 3-meal-a-day schedule. No snacking. Let your body adapt to using fat for fuel between meals.

3. Fasting Protocol: Introduction to Autophagy

  • Objective: Trigger cellular repair without excessive stress.
  • Protocol: Introduce a daily 16:8 intermittent fasting (IF) window.
    • Example: Finish dinner by 8 PM, break your fast at 12 PM the next day.
    • Hydration: During the fast, consume water, black coffee, and mineral-rich salt (e.g., Redmond Real Salt) to maintain electrolyte balance.
    • Week 3: Attempt one 24-hour fast (e.g., dinner to dinner). Monitor how you feel and your HRV/recovery the next day.

4. Exercise Routine: Strength & Foundation

  • Objective: Build lean muscle mass (crucial for longevity and glucose disposal) and work capacity.
  • Split: 3x full-body strength training, 1x LISS, 1x active recovery.
    • Strength (3x/week): Focus on compound movements.
      • Day A: Squat (Barbell Back or Goblet), Bench Press, Barbell Row.
      • Day B: Deadlift (Conventional or Romanian), Overhead Press, Pull-ups/Lat Pulldowns.
      • Protocol: 4 sets of 6-8 reps. Focus on progressive overload.
    • Low-Intensity Steady State (LISS) (1x/week): 45-60 minute brisk walk, hike, or Zone 2 cardio (keep HR below 75% of max). This builds mitochondrial efficiency.
    • Active Recovery (1x/week): Gentle yoga, stretching, foam rolling.

5. Stress Resilience & Sleep

  • Objective: Calibrate your nervous system and prioritize deep, restorative sleep.
  • HRV Training: Use your Oura/WHOOP data. Identify what tanks your HRV (late meals, alcohol, intense evening workouts, arguments). Modify your behavior.
  • Evening Shutdown Protocol (1 hour before bed):
    1. No screens (or wear blue-blocking glasses).
    2. Dim all lights.
    3. 10-minute meditation (using an app like Waking Up or Calm).
    4. 5-minute nasal breathing box breath: Inhale 4s, Hold 4s, Exhale 4s, Hold 4s.
    5. Take an Epsom salt (magnesium sulfate) bath.

6. Supplement Stack (Month 1: Foundations)

  • Morning:
    • Creatine Monohydrate: 5g. For cellular energy (ATP), brain health, and muscle performance.
    • Vitamin D3 + K2: 4000-5000 IU D3 / 100-200 mcg K2. Essential for immune function and calcium regulation. (Dose based on blood levels).
    • Omega-3 (Fish Oil): 2-4g, providing at least 1.5g EPA/DHA. For inflammation reduction and brain health.
  • With Meals:
    • Magnesium Glycinate/Threonate: 400mg. For relaxation, sleep quality, and over 300 enzymatic processes. Threonate is particularly good for the brain.
    • High-Purity Multivitamin (e.g., Thorne, Seeking Health): To fill any micronutrient gaps.
  • Evening:
    • L-Theanine: 200mg. Promotes alpha brain waves for a calm, alert state and synergizes with caffeine.
    • Apigenin: 50mg. A flavonoid that acts as a mild GABAergic modulator for deeper sleep.

Phase 2: Performance Amplification & Bio-Stacking (Month 2)

Goal: Layer in more advanced protocols. We've built the foundation; now we build the high-performance engine.

1. Dietary Protocol: Targeted Keto & Protein Cycling

  • Objective: Fuel high-intensity workouts while maintaining a primarily ketogenic state.
  • Protocol: Targeted Ketogenic Diet (TKD). On your 3 strength training days, consume 25-35g of fast-acting carbs (e.g., dextrose, or white rice) 30 minutes before your workout. Your CGM will help you dial in the perfect amount to fuel performance without kicking you out of ketosis.
  • Protein Cycling: On your strength training days, increase your protein intake to 1.6-2.0g per kg of lean body mass to maximize muscle protein synthesis (MPS). On other days, drop back to 1.2-1.5g/kg.

2. Fasting Protocol: The Longevity Fasting Mimicking Diet (FMD)

  • Objective: Deeply stimulate stem cell regeneration and autophagy.
  • Protocol: Instead of a 24-hour fast, perform a 3-day Fasting Mimicking Diet (e.g., ProLon DIY or a carefully constructed homemade version) in Week 2 of this month.
    • This is a low-calorie (~800-1100 kcal/day), low-protein, high-fat plan that tricks your body into a fasting state while still providing some nutrition.
    • Crucial: Plan this for a low-stress period. Track your HRV and recovery diligently before, during, and after.

3. Exercise Routine: Introducing HIIT & Power

  • Objective: Boost VO2 max, a key predictor of longevity, and increase explosive power.
  • Split: 2x Strength, 2x HIIT, 1x LISS, 1x Recovery.
    • Strength (2x/week): Continue the compound lift focus, but increase intensity. Consider adding a power-focused day: 5 sets of 3 reps on main lifts, moving the weight as explosively as possible.
    • High-Intensity Interval Training (HIIT) (2x/week):
      • Option A (Sprints): 8 rounds of 30-second all-out sprints on a bike or rower, followed by 90 seconds of easy recovery.
      • Option B (Kettlebells): 10 rounds of 20 seconds of kettlebell swings, 10 seconds of rest (Tabata protocol).
    • LISS (1x/week): Continue your Zone 2 session, aiming for 60 minutes.

4. Stress Resilience: Advanced Breathwork & Cold Exposure

  • Objective: Strengthen your nervous system's ability to switch between sympathetic ("fight or flight") and parasympathetic ("rest and digest") states.
  • Cold Exposure (3-4x/week):
    • Protocol: End your morning shower with 2-3 minutes of the coldest possible water.
    • Progression: In Week 3, try a full ice bath for 3 minutes at 10-12°C (50-54°F). Focus on controlling your breath. This is a powerful hormetic stressor that boosts norepinephrine and metabolic rate.
  • Physiological Sigh (Daily): The fastest way to calm your nervous system. When stressed, perform: 1) A double inhale through the nose (one deep, then another top-off). 2) A long, full exhale through the mouth. Repeat 1-3 times.

5. Supplement Stack (Month 2: Performance Focus)

  • Continue Month 1 stack.
  • Pre-Workout (on Strength/HIIT days):
    • Citrulline Malate: 8g. For vasodilation (pump) and performance.
    • Beta-Alanine: 3.2g. For muscular endurance (can cause paresthesia, "tingles").
    • Caffeine: 200mg. For focus and power output.
  • During FMD Week:
    • Suspend most supplements. Continue with electrolytes.
  • New Additions:
    • NMN or NR (Nicotinamide Riboside): 250-500mg daily in the morning. Precursors to NAD+, a critical coenzyme for energy metabolism and DNA repair. (Cycle 8 weeks on, 2 weeks off).
    • Urolithin A: 500mg daily. To promote mitophagy (clearing of damaged mitochondria).

Phase 3: Peak Optimization & Autoregulation (Month 3)

Goal: Refine and personalize the protocol based on 2 months of data. Become an intuitive biohacker, using data to guide your actions.

1. Dietary Protocol: Metabolic Flexibility & Carb Refeeds

  • Objective: Be metabolically flexible—able to switch seamlessly between burning fat and carbs.
  • Protocol: Cyclical Ketogenics.
    • 5-6 days/week: Remain in ketosis.
    • 1 day/week (e.g., Saturday): Perform a strategic "carb refeed." Consume 200-300g of clean carbohydrates (sweet potatoes, squash, white rice, fruit) after a strenuous workout.
    • Purpose: Replenish muscle glycogen, boost leptin (satiety hormone), and provide a psychological break. Your CGM is essential here to understand your body's response.

2. Fasting Protocol: Autoregulated Fasting

  • Objective: Fast based on biological feedback, not a rigid schedule.
  • Protocol: Use your HRV and RHR. If your morning HRV is high and RHR is low, your body is recovered and ready for a longer fast (e.g., extend your 16:8 to 20:4 or another 24-hour fast). If HRV is low and RHR is high, prioritize nutrition and recovery. Break your fast at 16 hours.

3. Exercise Routine: Autoregulation & Periodization

  • Objective: Train smarter, not just harder, by adapting daily intensity to your recovery state.
  • Autoregulation:
    • Check your Oura/WHOOP "Recovery Score" each morning.
    • Score >80% (Green Zone): Go for it. This is a day for a personal record, an extra HIIT session, or a higher-intensity lift.
    • Score 40-79% (Yellow Zone): Stick to the plan. This is your baseline workout.
    • Score <40% (Red Zone): De-load. Focus on active recovery: LISS cardio, mobility work, stretching. Do not push your body into a state of overtraining.
  • Split: Mix and match from Month 2, but let your recovery score dictate the intensity. Consider taking a full "de-load" week in Week 3, reducing volume and intensity by 50% to allow for supercompensation.

4. Stress Resilience: Neurofeedback & Meditation

  • Objective: Directly train your brainwaves for improved focus and calm.
  • Neurofeedback (Conceptual/Accessible): While professional neurofeedback is expensive, you can approximate its effects with at-home tech.
    • Muse Headband: A meditation headband that gives you real-time feedback on your brain activity, training you to enter deeper meditative states. Use this 3-5 times a week.
  • Advanced Meditation: Continue your practice, but extend sessions to 20-30 minutes. Explore non-dual or "open-awareness" meditation techniques.

5. Supplement Stack (Month 3: Refinement & Cycling)

  • Continue Month 2 stack, but introduce cycling.
  • Cycling Protocol:
    • Week 9-10: Full stack.
    • Week 11 (De-load): Take a break from all performance supplements (Citrulline, Beta-Alanine, Caffeine, NMN). Keep your foundational stack (Creatine, Vit D, Omega-3, Mag).
    • Week 12: Re-introduce the performance stack. Notice if their effects are enhanced after the break.
  • New Additions (Optional/Experimental):
    • Spermidine: 1-3mg daily. Another potent autophagy inducer.
    • Fisetin: 500mg, 2 consecutive days per month. A powerful senolytic (helps clear out senescent "zombie" cells).

Beyond Month 3: The Lifelong Practice

After 3 months, you will possess an unprecedented understanding of your own biology. The plan is no longer a prescription; it's a toolkit.

  • Continue quarterly blood work: Lipid panel, HbA1c, hs-CRP (inflammation), vitamin D, testosterone, cortisol, and a full metabolic panel.
  • Embrace Seasonality: Consider more intensive protocols (like extended fasts) in the winter, and more high-intensity activity in the summer.
  • Never Stop Learning: The science of longevity is evolving rapidly. Stay curious, be your own experiment, and prioritize long-term health and consistency over short-term intensity.
Advanced Longevity Plan (Biohacker)

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Provider
Zhipu
Released
2025-09-30
Size
XLARGE
Context
202,752 tokens

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