Advanced Longevity Plan (Biohacker)

Important note: The following is an intensive, experimental plan intended for healthy adults with physician oversight. It is not medical advice. Discuss all supplements, fasting, heat/cold exposure, and any prescription considerations with your clinician, especially if you have cardiovascular, metabolic, thyroid, psychiatric, or kidney/liver conditions, are on medication, or have a history of eating disorders. Stop or scale back if you experience red flags (dizziness, chest pain, fainting, persistent fatigue, sleep disruption).

Objective

• Maximize healthspan, physical and cognitive performance over 12 weeks, while building sustainable habits and measurable improvements in:
  • VO2max, strength, muscle mass, body fat, glycemic control, HRV, sleep quality, inflammation (hs-CRP), and subjective wellbeing.
• Approach: phased training, cyclical ketogenic nutrition with strategic refeeds, targeted supplementation with cycling, hormetic stress (heat/cold) with recovery, HRV/neurofeedback-based stress regulation, and dense biomonitoring.

Week 0 (Setup and Baseline)

1. Baseline testing

• Labs (fasting): apoB, lipid panel + Lp(a), CMP, CBC, hs-CRP, fasting glucose/insulin (HOMA-IR), HbA1c, uric acid, TSH+free T3/T4, ferritin/iron/TIBC, B12, folate, 25(OH)D, IGF-1, morning cortisol, testosterone/estradiol/SHBG (or DHEA-S), creatinine/eGFR, ALT/AST, urine albumin/creatinine. Optional: omega-3 index.
• Body comp and fitness: DEXA, resting BP, resting HR, grip strength, 1RM estimates (or 5RM) for squat/press/deadlift, VO2max estimate (Cooper test or wearables), 5-minute HRV baseline (supine, same time daily x5 days), sit-to-stand test, 1-minute push-ups, 1-minute sit-ups, 10-m gait speed.
• Cognitive baseline: simple reaction time (e.g., HumanBenchmark), N-back accuracy, Stroop task, Psychomotor Vigilance Task (PVT) app.
• Gut: note GI symptoms; consider 3-day food symptom log.

2. Gear and apps

• Wearables: Oura or Whoop (sleep/HRV), Apple Watch or Garmin (workouts/VO2), optional CGM for 4 weeks (Levels/Nutrisense), blood pressure monitor (AM/PM), blood glucose/ketone meter (Keto Mojo), breath ketone (optional Biosense).
• Software: Cronometer (macro/micro tracking), TrainingPeaks or TrainerRoad (programming), HRV4Training or Elite HRV (morning HRV), HeartMath or Breathwrk (biofeedback), MUSE S or FocusCalm (consumer neurofeedback), Notion/Google Sheet for dashboard.
• Environment: bedroom 17–19 C; blackout curtains; 10,000 lux lamp for mornings; blue-light filters; HEPA air purifier; water filter.

3. Targets and rules

• Body composition: protein 1.6–2.2 g/kg/day; body fat reduction if needed 0.3–0.7%/week.
• Activity floor: 8,000–12,000 steps/day; 3–5x/week sauna or hot bath; 2–4x/week cold exposure (timing away from strength days).
• HRV-based autoregulation: if 3-day rolling HRV drops >15% from personal baseline and RHR +5–7 bpm, reduce intensity/volume 30–50% for 48–72 hours.
• Post-meal glucose: aim <140 mg/dL peak, back to baseline within 3 hours; adjust carbs and order of eating accordingly.

Nutrition: cyclical ketogenic with strategic refeeds

• Default (Mon–Fri): low-carb ketogenic
  • Protein: 1.8–2.2 g/kg/day (prioritize lean, collagen-rich cuts + fish).
  • Net carbs: 20–50 g/day from non-starchy veg and berries.
  • Fat: to satiety (mostly mono/polyunsaturated, olive oil, avocado, nuts; include omega-3 fish).
  • Fiber: 30–50 g/day from non-starchy veg, chia/flax, psyllium if needed.
  • Electrolytes: sodium 4–6 g/day total (food + electrolytes), potassium 3–4.7 g/day, magnesium 300–400 mg/day from food/supp.
• Refeeds (Sat, optional Wed): 1–2 days/week higher carb to support thyroid, hormones, performance
  • Carbs: 2–3 g/kg/day from low-processed sources (potatoes, rice, oats, fruit), start meal with protein/veg, limit fat those days.
  • Place refeeds around heaviest strength/HIIT days.
• Meal timing
  • Most days: 16:8 time-restricted eating. Feed window noon–8 pm. Protein-forward first meal.
  • One 24-hour fast each week (e.g., dinner-to-dinner), skipped during deload weeks or if under-recovered.
  • Optional (with medical oversight): One 36-hour fast in Week 8 OR a 4–5 day fasting-mimicking diet (FMD) substitute; choose one, not both.
• Supplements to support keto transition: adequate sodium, magnesium; consider MCT oil 5–10 mL to ease early weeks.

Core supplement stack and cycling Note: Verify interactions (e.g., SSRIs, thyroid meds, anticoagulants, antihypertensives). Start one new item every 3–4 days to assess tolerance.

Daily foundation (generally continuous for 12 weeks)

• Creatine monohydrate: 5 g/day, any time. Supports strength and cognition.
• Omega-3 EPA/DHA: 1–2 g/day combined with meals. Aim for omega-3 index >8%.
• Vitamin D3: 1,000–4,000 IU/day to maintain 30–50 ng/mL; re-check at week 8. Pair with K2 MK-7 90–180 mcg/day.
• Magnesium glycinate: 200–400 mg in evening.
• Glycine: 3 g in evening (sleep/GLUT support); optional collagen 10 g + vitamin C 100–200 mg for connective tissue.
• Taurine: 1–2 g/day (cardiometabolic support; can take pre-bed or pre-workout).
• Electrolyte mix: enough to reach sodium/potassium targets above.

Metabolic and mitochondrial (cycle)

• Urolithin A: 500 mg/day with food for 12 weeks.
• Spermidine: 1 mg/day with food; cycle 5 days on, 2 days off.
• Berberine: 500 mg before largest carb meal, up to 2x/day on refeed days only; cycle 5 days on, 2 days off. Avoid if on hypoglycemics or with low BP; watch GI.
• NAD support: NR 300–500 mg/day or NMN 250–500 mg/day; cycle 5 days on, 2 days off, or 8 weeks on, 2 weeks off. Evidence mixed; optional.

Cognition and stress (cycle to avoid tolerance)

• Caffeine 50–200 mg AM only; optional L-theanine 100–200 mg with caffeine.
• Lion’s Mane extract: 500–1,000 mg/day (AM), 8 weeks on, 2 weeks off.
• Rhodiola rosea (3% rosavins): 200–400 mg AM, 3 weeks on, 1 week off. Avoid if bipolar.
• Bacopa monnieri (standardized): 300 mg/day with food for 8–12 weeks. May cause GI sedation initially.
• Ashwagandha (KSM-66 or Sensoril): 300–600 mg/day, 5 days on, 2 off. Caution with thyroid autoimmunity or sedatives.

Anti-inflammatory/polyphenols (optional)

• Curcumin phytosome: 500–1,000 mg/day with fat; avoid with anticoagulants.
• Cocoa flavanols: ~500 mg/day or 20–30 g 85% dark chocolate.

Sleep adjuncts (only if needed)

• Apigenin 50 mg or magnesium L-threonate 2 g in evening; try one at a time. Melatonin 0.3–1 mg short term for jet lag only.

Avoid self-directed use of prescription agents (e.g., metformin, GLP-1s, rapamycin). Discuss risks/benefits with a physician if considering them.

Training blueprint (12 weeks) Weekly structure (typical)

• Strength: 4 sessions/week (upper/lower split or push/pull/legs + full-body). Progressively overload with deload weeks.
• Zone 2 cardio: 3 sessions/week, 30–60 min each (Maffetone HR ≈ 180 − age ±5 bpm).
• HIIT/VO2: 1–2 sessions/week.
• Mobility/Prehab: 10–15 min daily.
• NEAT: 8–12k steps/day; add rucking 1–2x/week if joints tolerate.
• Power/Plyo: micro-dose 1–2x/week (low volume).
• Avoid cold immersion within 6–8 hours after strength sessions (may blunt hypertrophy).

Weeks 1–2 (Foundation and technique)

• Strength (RPE 6–7): Day A (Lower): Back squat 3×5, RDL 3×6, split squat 3×8/side, calf raise 3×12, core carry 3×40 m. Day B (Upper Push): Bench or DB press 3×5, incline DB 3×8, ring push-up 3×AMRAP, overhead press 3×6, face pulls 3×12. Day C (Lower Hinge): Deadlift 3×5, front squat 3×5, hip thrust 3×8, ham curl 3×10, Copenhagen plank 3×20 s. Day D (Upper Pull): Weighted pull-up 3×5 (or lat pulldown), bent row 3×6, rear delt 3×12, biceps/triceps 2×12.
• Zone 2: 3×40 min (bike/row/run).
• HIIT: 1× “10×1 min hard/1 min easy” at 90–95% max HR.
• Plyo/power: 3×3 box jumps + 3×10 med-ball slams, 1–2x/wk.
• Mobility: daily 10 min (couch stretch, thoracic extension, ankle dorsiflexion, hip airplanes).

Weeks 3–4 (Metabolic priming and base)

• Strength: same split; add one set or +2.5–5% load; keep RPE ≤8.
• Zone 2: progress to 3×50–60 min.
• HIIT: 1–2×/wk: Option 1: 4×4 min at ~90–95% max HR, 3 min easy between. Option 2: 6–8×30 s all-out / 2.5 min easy (once weekly only).
• Add 1 weekly 24-hour fast on rest day. Introduce 1 weekly carb refeed on heaviest leg day.

Weeks 5–7 (Build: performance and hypertrophy)

• Strength: periodize 3-week build. Week 5: 4×5 main lifts (RPE 7–8), accessories 3–4×8–12. Week 6: 5×3 main lifts (heavier, RPE 8), accessories 3×6–10. Week 7: 4×6 hypertrophy focus, tempo reps 3–1–X on first set.
• Add loaded carries and farmer’s walks 3×40–60 m twice weekly.
• HIIT/VO2: 2×/wk (one 4×4, one 30/30×12).
• Zone 2: 2×60 min + 1×30 min easy.
• One 24-hour fast per week; 1–2 carb refeeds/wk.
• Optional altitude/hypoxic interval (if safely available): 8–12 min total hypoxic intervals under supervision.

Week 8 (Autophagy block + deload)

• Training deload: reduce volume by 40–50%, intensity by 10–15%.
• Choose one: 36-hour fast (with electrolyte support; skip HIIT that week), OR 4–5 day FMD at ~40–50% of calories, ≥1.0 g/kg protein/day.
• Extra sauna emphasis. Sleep ≥8 hours.

Weeks 9–10 (Hormesis consolidation, peak VO2 focus)

• Strength: resume build, vary stimuli (front squats, incline press, snatch-grip RDL). RPE 7–8.
• Power: add 5–10 min sprint mechanics and plyos (bounds, low hurdle hops).
• VO2: 2×/wk: 5×3 min at 100–110% of power/pace at VO2max; 3 min recovery.
• Zone 2: maintain 2–3 sessions.
• Refeeds on VO2 days; keep weekly 24-hour fast if recovery allows.

Weeks 11–12 (Peak and consolidate)

• Week 11: Slightly reduced volume, maintain intensity (strength 3×3 main lifts).
• Week 12: Testing and deload. Retest 5RM estimates, VO2max test, 5K or 12-min run, grip strength, HRV trends, CGM metrics, sleep scores. Deload last 3–4 days; focus on mobility, Zone 2, and sleep.

Heat/cold protocols

• Sauna: 3–5 sessions/week. Start 10–15 min at 80–90 C, build to 20–30 min; include 1–3 cool-downs. Hydrate; add 1–2 g sodium post-session.
• Cold exposure: 2–4×/week, 2–5 min at 10–15 C or cold showers 3–5 min. Place away from strength sessions by ≥6–8 hours. Warm up naturally afterward.

Stress resilience & neurofeedback

• Morning HRV: adjust training when down.
• Breathwork: 10–15 min/day (coherent breathing ~6 breaths/min). Add physiological sighs during stress.
• CO2 tolerance: weekly BOLT test.
• Neurofeedback (consumer EEG): 10–20 min/day, 4–5 days/week. Alpha-up (Weeks 1–4), SMR/beta focus (Weeks 5–8), alternate in Weeks 9–12; stop 3–4 hours before bed.
• NSDR/Yoga Nidra: 10–20 min afternoons.
• Psychology: 3-minute gratitude nightly; daily 10-minute social connection.

Daily rhythm & sleep

• Morning outdoor light; dim evening light. Cool bedroom 17–19 C. Caffeine cutoff 8–10 hours before bed. 7.5–9 hours/night. Simple wind-down routine.

Nutrition tactics

• Protein 3–4 meals at 0.4–0.6 g/kg per meal; leucine-rich.
• Refeed order: veg → protein → carbs; optional vinegar before high-carb meals.
• Fermented foods daily; selenium via 2 Brazil nuts/day; choline from eggs/liver.
• Hydration: 30–35 mL/kg/day; electrolytes as needed.
• Alcohol: ideally zero; ≤1 drink/week if any; avoid within 3 hours of bedtime.

Weekly outline (example)

• Mon: Upper + Z2 30–40; keto.
• Tue: Lower + mobility; sauna; keto.
• Wed: VO2 4×4 + plyos; refeed; HRV/coherence work.
• Thu: Upper (hypertrophy) + Z2; keto.
• Fri: Lower (heavy); sauna; keto or start 24h fast.
• Sat: Cold AM; Z2/ruck 60; refeed dinner.
• Sun: Recovery (yoga, mobility, NSDR); prep; alpha-up neurofeedback; keto.

Guardrails

• HRV down >15% or RHR up ≥7 bpm: swap to Z2, cut volume 30–40% for 48–72 h.
• Poor sleep: pull intensity; shift HIIT earlier.
• CGM spikes: adjust carbs, add post-meal walks.
• Weight/mood dips: raise calories/refeeds.

Targets after 12 weeks

• VO2max +5–15%; strength +5–15%; body fat −3–6% (if needed) with lean mass preserved; HRV trend +5–20%; RHR −3–7 bpm; hs-CRP toward <1 mg/L; fasting insulin <7 μIU/mL.

Contingencies

• Suspected thyroid slowdown: increase refeeds to 2×/week, carbs around training, check labs.
• Sleep issues on keto: add 20–40 g slow carbs at dinner; Mg + glycine; move HIIT earlier.
• Vegan/vegetarian: prioritize complete proteins; supplement creatine, B12, algal DHA/EPA; consider taurine.
• Joint issues: swap running HIIT for bike/row; collagen + vitamin C 60 min pre-session.

Clinician discussion list

• apoB strategy, ferritin source, sleep apnea screening, and any Rx longevity agents under supervision.