Advanced Longevity Plan (Biohacker)

Below is a comprehensive, cutting-edge 3-month longevity plan tailored for a biohacker aiming to optimize longevity, physical performance, and cognitive function. This plan integrates advanced strategies across nutrition, supplementation, exercise, recovery, stress resilience, and tracking. It assumes the individual is healthy, has some experience with biohacking, and has access to advanced tools and resources. Always consult with a healthcare professional before starting such an intensive program, especially for supplements and fasting.

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Overview of the 3-Month Longevity Plan

Goal: Optimize cellular health, mitochondrial function, physical performance, cognitive clarity, and stress resilience while promoting longevity through evidence-based and experimental biohacking strategies.

Structure: The plan is divided into three 4-week phases with progressive intensity and focus areas. Each phase builds on the previous one, incorporating adaptation and optimization.

• Phase 1 (Weeks 1-4): Foundation Building – Establish dietary and lifestyle baselines, optimize sleep, and introduce foundational supplements and tracking.
• Phase 2 (Weeks 5-8): Performance Optimization – Intensify exercise, refine fasting protocols, and enhance cognitive and stress resilience strategies.
• Phase 3 (Weeks 9-12): Peak Longevity & Recovery – Focus on advanced longevity interventions, deep recovery, and personalized fine-tuning based on data.

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Core Components Across All Phases

1. Tracking & Personalization

Use advanced wearables and testing to monitor progress and adjust protocols. Key metrics to track:

• Wearables:
  • Oura Ring or WHOOP: Sleep quality, readiness score, heart rate variability (HRV).
  • Garmin or Apple Watch: Activity levels, heart rate, stress tracking.
  • Continuous Glucose Monitor (CGM) like Levels or Dexcom: Monitor blood glucose response to diet and fasting.
• Biomarkers (Baseline at Week 1, Retest at Week 6 and Week 12):
  • Blood tests: Lipid panel, fasting insulin, HbA1c, inflammatory markers (CRP, IL-6), NAD+ levels (if accessible), telomere length (if accessible via specialized labs).
  • Gut microbiome testing (e.g., Viome) to optimize diet.
  • Optional: Genetic testing (e.g., 23andMe) for personalized supplement and diet recommendations (e.g., MTHFR mutations).

2. Mindset & Journaling

• Daily journaling to track mood, energy, and subjective performance.
• Weekly reflection to assess adherence and make adjustments.

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Phase 1: Foundation Building (Weeks 1-4)

Dietary Protocol: Cyclical Ketogenic Diet (CKD)

• Goal: Induce metabolic flexibility and optimize mitochondrial efficiency.
• Macronutrient Split: 70-75% fat, 20-25% protein, 5-10% carbs on keto days; carb refeed days at 50% carbs, 30% fat, 20% protein.
• Structure:
  • Days 1-5: Strict keto (<30g net carbs/day) using foods like avocados, olive oil, fatty fish (salmon, mackerel), grass-fed beef, eggs, and low-carb vegetables (spinach, kale, broccoli).
  • Days 6-7: Carb refeed (100-150g carbs) with clean sources like sweet potatoes, quinoa, and berries to replenish glycogen and prevent metabolic slowdown.
• Timing: Practice time-restricted eating (TRE) with a 16:8 fasting window (fast for 16 hours, eat within 8 hours).
• Hydration: 3-4 liters of water daily with added electrolytes (sodium: 3-5g, potassium: 1-2g, magnesium: 400-600mg) to support keto adaptation.

Supplements (Foundational Stack)

• Morning (with breakfast):
  • Multivitamin: Thorne Basic Nutrients 2/Day (as a baseline).
  • Omega-3 (EPA/DHA): 2-3g combined (Nordic Naturals Ultimate Omega).
  • Vitamin D3 + K2: 5,000 IU D3 + 100mcg K2-MK7 (Thorne D/K2 Drops) if blood levels are suboptimal (aim for 50-70 ng/mL).
  • Magnesium Glycinate: 200-400mg for sleep and recovery (Pure Encapsulations).
• Evening (before bed):
  • Ashwagandha: 600mg (Sensoril or KSM-66) for stress reduction.
  • Melatonin: 1-3mg if sleep onset is delayed (sublingual for faster absorption).
• Cycling: No cycling in Phase 1; establish baseline tolerance.

Exercise Routine

• Goal: Build foundational strength and endurance while minimizing stress.
• Weekly Structure (5 days active, 2 rest/recovery):
  • Strength Training (3x/week): Full-body compound lifts (squats, deadlifts, bench press, pull-ups) – 3 sets of 8-12 reps at 60-70% 1RM. Focus on form and progressive overload.
  • Cardio (2x/week): Zone 2 training (60-70% max heart rate) for 30-45 minutes (e.g., jogging, cycling) to build aerobic base.
  • Recovery (Daily): 10-15 minutes of mobility work (yoga or dynamic stretching).
• Tracking: Log workouts via apps like Strong or MyFitnessPal; monitor readiness via WHOOP/Oura.

Stress Resilience & Cognitive Training

• Daily Practice: 10 minutes of mindfulness meditation (Headspace or Calm app) to reduce cortisol.
• HRV Training: Use Elite HRV app with a chest strap (Polar H10) to practice coherent breathing (6 breaths/minute) for 5 minutes daily to improve autonomic balance.
• Sleep Optimization: Target 7-9 hours/night. Blackout curtains, blue light blocking glasses after 8 PM, and a consistent bedtime routine.

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Phase 2: Performance Optimization (Weeks 5-8)

Dietary Protocol: Targeted Ketogenic Diet (TKD) + Intermittent Fasting

• Goal: Enhance performance while maintaining ketosis.
• Macronutrient Split: Same as CKD but with targeted carb intake (25-50g) 30-60 minutes pre-workout on strength/HIIT days (e.g., dextrose or cyclic dextrin).
• Fasting Regimen: Alternate between 16:8 TRE (5 days/week) and 24-hour water fast (1-2 days/week, ideally on rest days) to promote autophagy and metabolic reset.
• Key Addition: Increase polyphenol intake with foods like dark chocolate (85%+), green tea, and turmeric (with black pepper for curcumin absorption) for antioxidant support.

Supplements (Performance Stack)

• Add to Foundational Stack:
  • Morning (Pre-Workout):
    • Creatine Monohydrate: 5g daily (post-loading if not done previously) for strength and cognitive benefits.
    • Beta-Alanine: 2-3g for endurance (tingling is normal; split dose if needed).
    • L-Citrulline Malate: 6-8g for nitric oxide boost and endurance.
  • Post-Workout:
    • Branched-Chain Amino Acids (BCAAs) or Whey Protein: 20-30g if protein intake is low.
  • Evening (Longevity Focus):
    • Resveratrol: 250-500mg (with fat for absorption) for SIRT1 activation.
    • Nicotinamide Mononucleotide (NMN): 250-500mg sublingual (e.g., Alive by Science) to boost NAD+ levels.
• Cycling: Take 1 week off creatine every 4 weeks to prevent receptor downregulation; alternate high-dose NMN (500mg) with low-dose (250mg) weekly.

Exercise Routine

• Goal: Push performance with intensity while maintaining recovery.
• Weekly Structure (6 days active, 1 rest):
  • Strength Training (3x/week): Progressive overload with 4 sets of 6-8 reps at 70-85% 1RM. Incorporate supersets for efficiency.
  • HIIT (2x/week): 20-30 minutes of sprint intervals (e.g., 30s sprint, 90s rest x 8 rounds) to boost VO2 max.
  • Cardio (1x/week): Zone 2 training for 45-60 minutes.
  • Recovery (Daily): Foam rolling, 10 minutes of sauna (if available) 3x/week for heat shock protein activation.
• Tracking: Adjust intensity based on HRV and readiness scores; aim for 1-2% weekly strength increases.

Stress Resilience & Cognitive Training

• Neurofeedback (Optional): If accessible, use a device like Muse or Neuroptimal for 2-3 sessions/week (20 minutes each) to train brainwave patterns (alpha/theta balance).
• Cold Exposure: 2-3 minutes of cold showers or ice baths (3x/week) post-workout to enhance recovery and vagal tone.
• HRV Training: Increase to 10 minutes/day; target consistent improvement in HRV score.

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Phase 3: Peak Longevity & Recovery (Weeks 9-12)

Dietary Protocol: Keto + Extended Fasting

• Goal: Maximize longevity pathways (autophagy, sirtuins) while preserving performance.
• Structure: Maintain TKD but introduce a 48-hour fast once every 2 weeks (water, black coffee, electrolytes only) to deepen ketosis and cellular repair.
• Microbiome Focus: Add fermented foods (sauerkraut, kimchi, kefir) daily and a high-fiber prebiotic (e.g., inulin, 5-10g/day) to support gut health post-fasting.

Supplements (Longevity Stack)

• Add to Performance Stack:
  • Morning:
    • Quercetin + Fisetin: 500mg each, 3 days/week for senolytic effects (clear senescent cells).
    • Pterostilbene: 50-100mg as a resveratrol alternative for bioavailability.
  • Evening:
    • Metformin (if prescribed): 500mg 1-2x/day for AMPK activation (consult physician due to off-label use for longevity).
    • Rapamycin (if accessible/prescribed): 2-5mg once weekly for mTOR inhibition (consult physician; highly experimental).
• Cycling: Take 1 week off all longevity supplements (NMN, resveratrol, etc.) in Week 11 to prevent adaptation; maintain foundational stack.

Exercise Routine

• Goal: Maintain gains while prioritizing recovery and longevity.
• Weekly Structure (5-6 days active):
  • Strength Training (2-3x/week): Maintenance at 70-80% 1RM, focus on eccentric movements for tendon health.
  • HIIT (1-2x/week): Reduce to 15-20 minutes for sustainability.
  • Low-Impact Cardio (2x/week): Zone 2 or light swimming/walking for 45 minutes.
  • Recovery (Daily): Increase sauna to 4x/week; add contrast therapy (alternate hot/cold exposure) if possible.
• Tracking: Prioritize recovery metrics (HRV, sleep scores) over performance gains.

Stress Resilience & Cognitive Training

• Advanced Meditation: 15-20 minutes/day of transcendental meditation or guided visualization.
• Breathwork: Incorporate Wim Hof Method (3 rounds of 30 breaths + breath hold) 3x/week for stress resilience and oxygenation.
• Social Connection: Dedicate time weekly for meaningful social interactions to boost oxytocin and mental health.

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Weekly Schedule (Example for Phase 2)

Day	Diet/Fasting	Exercise	Recovery/Stress	Tracking
Monday	Keto, 16:8 TRE	Strength (Full Body)	HRV Training, Mobility	Log HRV, Sleep
Tuesday	Keto, 16:8 TRE	HIIT (Sprints)	Cold Shower, Meditation	CGM Check
Wednesday	Keto, 16:8 TRE	Rest	Sauna, Mindfulness	Readiness Score
Thursday	Keto, 16:8 TRE	Strength (Full Body)	Foam Rolling, HRV	Log Workout
Friday	Keto + Pre-Workout Carbs	HIIT (Intervals)	Cold Shower, Meditation	CGM Check
Saturday	24-Hour Fast	Zone 2 Cardio	Sauna, Deep Relaxation	Journal Reflection
Sunday	Carb Refeed, 16:8 TRE	Rest	Mobility, Social Time	Weekly Review

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Key Longevity Principles

1. Mitochondrial Health: Prioritize keto, fasting, and NAD+ boosters (NMN) to enhance energy production.
2. Inflammation Control: Use omega-3s, polyphenols, and curcumin to keep systemic inflammation low.
3. Autophagy & Cellular Repair: Leverage fasting and senolytics (quercetin, fisetin) to clear damaged cells.
4. Hormesis: Incorporate stressors like cold/heat exposure and intense exercise to build resilience.
5. Personalization: Continuously adjust based on wearable data, biomarker feedback, and subjective energy levels.

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Post-Plan Recommendations (After Week 12)

• Maintenance: Transition to a sustainable 5:2 fasting regimen (2 days of 500-600 calories, 5 days normal eating) or continue cyclical keto based on preference.
• Retesting: Repeat bloodwork and microbiome tests to assess improvements in key markers (e.g., insulin sensitivity, inflammation).
• Experimentation: Explore advanced therapies like hyperbaric oxygen therapy (HBOT), peptide therapy (e.g., BPC-157 for recovery), or IV nutrient drips if accessible and desired.

This plan is a blueprint for pushing the boundaries of longevity and performance. Adjust based on personal response, professional guidance, and evolving research in biohacking. Consistent tracking and adaptation are key to success.