Advanced Longevity Plan (Biohacker)

Below is a comprehensive, cutting-edge 3-month longevity plan designed for an advanced biohacker. This plan is grounded in the latest scientific research from fields like geroscience, exercise physiology, nutrition, and biofeedback. It aims to optimize longevity (e.g., via cellular repair and anti-aging mechanisms), physical performance (e.g., strength, endurance, and recovery), and cognitive performance (e.g., focus, memory, and neuroplasticity).

Key Principles and Prerequisites:

• Goals: Extend healthspan by targeting hallmarks of aging (e.g., mitochondrial health, inflammation reduction, autophagy), enhance physical capabilities (e.g., VO2 max, muscle mass), and boost cognitive function (e.g., through neuroprotection and synaptic plasticity).
• Customization: This plan assumes a baseline of good health (e.g., no major medical conditions). Start with a doctor's consultation to test for biomarkers (e.g., blood work for inflammation markers like CRP, hormones like testosterone, and nutrients like NAD+ levels). Adjust based on your data from wearables.
• Tracking Tools: Use advanced wearables like the Oura Ring (for sleep, HRV, and activity), Whoop (for recovery and strain), and a continuous glucose monitor (CGM) like Levels for real-time metabolic insights. Integrate apps like Apple Health or Google Fit for data aggregation.
• Safety and Monitoring: Track biometrics weekly (e.g., HRV, sleep quality, blood glucose). Cycle supplements to prevent tolerance. If adverse effects occur, pause and consult a professional. This plan is high-intensity; ensure adequate rest.
• Structure: The plan is divided into three months, with weekly themes. Each month builds on the previous one. Daily routines include diet, supplements, exercise, tracking, and stress techniques.
• Actionability: I've included specific dosages, schedules, and protocols. Track progress in a journal or app (e.g., Notion or Daylio).

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Month 1: Foundation Building

Focus: Establish baseline habits, optimize metabolic health, and build resilience. Emphasize learning your body's responses through tracking.

Dietary Protocols

• Primary Protocol: Cyclical Ketogenic Diet (CKD) with Intermittent Fasting (IF).
  • Why: Keto promotes ketosis for fat adaptation and mitochondrial biogenesis; IF enhances autophagy and insulin sensitivity.
  • Daily Structure:
    • IF Window: 16:8 (e.g., eat between 12 PM and 8 PM). On Days 1-5, maintain strict keto; on Days 6-7, allow a "refeed" with higher carbs for hormone balance.
    • Macro Breakdown:
      • Days 1-5 (Keto): 70-80% fats (e.g., avocados, MCT oil), 15-20% protein (e.g., wild-caught fish, grass-fed meat), 5-10% carbs (e.g., leafy greens).
      • Days 6-7 (Refeed): Increase carbs to 30-40% (e.g., sweet potatoes, berries) to replenish glycogen and boost thyroid hormones.
    • Caloric Intake: 2,000-2,500 calories/day (adjust based on wearable data; aim for a 0.5-1 lb/week fat loss if overweight).
    • Sample Meal Plan:
      • Breakfast (12 PM): Bulletproof coffee (e.g., coffee with 1 tbsp MCT oil and 1 tbsp grass-fed butter).
      • Lunch: Grilled salmon salad with olive oil dressing and spinach.
      • Dinner: Grass-fed steak with broccoli (pre-8 PM).
      • Refeed Day Example: Add a post-workout sweet potato with eggs.
  • Tracking: Use a CGM to monitor blood glucose stability; aim for fasting glucose <90 mg/dL.

Supplement Stacks

• Focus: Build foundational longevity and cognitive support. Cycle: 5 days on, 2 days off to prevent downregulation.
• Daily Stack (Morning):
  • Nicotinamide Riboside (NR) or NMN: 500 mg – Supports NAD+ for cellular energy and DNA repair.
  • Omega-3 (EPA/DHA): 2,000 mg – Reduces inflammation; take with food.
  • Vitamin D3: 2,000-5,000 IU (based on blood levels) – For immune and bone health.
• Daily Stack (Afternoon, for Cognition):
  • Lion's Mane Mushroom: 500 mg – Enhances neurogenesis and focus.
  • Bacopa Monnieri: 300 mg – Improves memory; cycle as above.
• Evening Stack (Before Bed):
  • Magnesium Glycinate: 400 mg – Aids sleep and muscle recovery.
  • Melatonin: 0.5 mg (only if needed for sleep adaptation) – Use sparingly to avoid dependency.
• Tracking: Log supplements in an app like MyFitnessPal and monitor HRV for effects.

Exercise Routines

• Frequency: 5 days/week (3 strength, 2 cardio/recovery).
• Strength Training (3x/week, e.g., Mon, Wed, Fri):
  • Full-body routine: 45-60 minutes. Focus on compound movements for muscle protein synthesis and bone density.
  • Sample Routine:
    • Squats: 3 sets of 8-10 reps at 70-80% max weight.
    • Deadlifts: 3 sets of 6-8 reps.
    • Bench Press: 3 sets of 8-10 reps.
    • Finish with core (e.g., planks: 3x 30-60 seconds).
    • Progression: Increase weight by 5% weekly if form allows.
• HIIT and Cardio (2x/week, e.g., Tue, Thu):
  • 20-30 minutes: Alternate 30 seconds high-intensity (e.g., sprints on a bike) with 90 seconds recovery. Aim for 80-90% max heart rate.
• Recovery (Daily): 10-15 minutes of walking or light yoga. Use a sauna (15-20 minutes at 160-180°F) 2x/week for heat shock proteins.
• Tracking: Use Whoop to monitor strain and recovery scores; aim for >80% recovery before hard days.

Stress Resilience Techniques

• Focus: Build baseline stress management.
• Daily Protocol:
  • HRV Training: 5-10 minutes/day using an app like Elite HRV. Breathe at 6 breaths/minute to optimize vagal tone.
  • Meditation: 10 minutes of mindfulness via apps like Calm.
• Weekly Advanced Technique: Introduce basic neurofeedback (e.g., use a device like Muse headband 1x/week for 10 minutes to train focus).
• Tracking: Log HRV daily; aim for an average >50 ms.

Weekly Schedule Overview

• Monday: Strength training + HRV training.
• Tuesday: HIIT + meditation.
• Wednesday: Strength training + sauna.
• Thursday: Cardio + neurofeedback.
• Friday: Strength training + journaling.
• Saturday: Active recovery (walk) + refeed day.
• Sunday: Rest + review wearable data.

Monitoring and Adjustments

• Weekly Review: Check wearable data for trends (e.g., if HRV drops, reduce intensity). Adjust diet based on CGM (e.g., if glucose spikes, tighten keto).
• Goal: By end of Month 1, achieve stable ketosis (test with urine strips) and improve HRV by 10-20%.

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Month 2: Optimization

Focus: Intensify protocols based on Month 1 data. Introduce advanced variations for deeper longevity benefits.

Dietary Protocols

• Primary Protocol: Targeted Ketogenic Diet (TKD) with Extended Fasting.
  • Why: TKD allows targeted carb intake around workouts for performance; extended fasting (e.g., 24-hour fasts) boosts autophagy.
  • Daily Structure:
    • IF Window: Advance to 18:6 (e.g., eat between 12 PM and 6 PM).
    • Macro Breakdown: Same as Month 1, but on workout days, add 20-30g carbs pre-workout (e.g., from exogenous ketones).
    • Weekly Fast: One 24-hour fast (e.g., water only on Wednesdays).
    • Sample Meal Plan: Similar to Month 1, but add exogenous ketones (e.g., beta-hydroxybutyrate) on HIIT days for fuel.
  • Tracking: Use CGM to ensure fasting improves glucose variability.

Supplement Stacks

• Focus: Optimize with anti-aging and performance enhancers. Cycle: 4 days on, 3 days off.
• Daily Stack (Morning):
  • Resveratrol: 500 mg – Activates sirtuins for longevity; combine with NMN for synergy.
  • Curcumin (with piperine): 500 mg – Reduces inflammation.
  • Previous Month 1 stack (e.g., NR, Omega-3).
• Daily Stack (Afternoon, for Cognition and Performance):
  • Alpha-GPC: 300 mg – Boosts acetylcholine for focus and muscle strength.
  • Rhodiola Rosea: 200 mg – Enhances stress resilience and energy.
• Evening Stack:
  • Apigenin: 50 mg – Promotes sleep and reduces oxidative stress.
  • Add Ashwagandha: 300 mg if stress is high (based on HRV).
• Tracking: Use blood tests mid-month to check NAD+ levels; adjust dosages.

Exercise Routines

• Frequency: 6 days/week (3 strength, 2 HIIT, 1 recovery-focused).
• Strength Training (3x/week): Progress from Month 1 by adding supersets (e.g., squats immediately followed by lunges).
• HIIT (2x/week): Increase to 4-6 intervals of 40 seconds high-intensity.
• Recovery (1x/week + daily elements): Introduce cold therapy (e.g., 5-10 minutes in a cold plunge or ice bath post-workout for inflammation reduction). Add mobility work like yoga.
• Tracking: Aim for VO2 max improvement (track via Garmin); use Oura for sleep optimization.

Stress Resilience Techniques

• Daily Protocol: Advance HRV training to 15 minutes; add breathwork (e.g., Wim Hof method for 5 minutes).
• Weekly Advanced Technique: Neurofeedback 2x/week (e.g., focus on alpha waves for relaxation).
• Tracking: Target HRV >60 ms; integrate cognitive exercises (e.g., dual n-back apps for 10 minutes/day).

Weekly Schedule Overview

• Build on Month 1, but add: Wednesday as fasting day with light activity; Saturday for advanced recovery (e.g., cold therapy + yoga).

Monitoring and Adjustments

• Biweekly Review: Analyze wearable data for overtraining (e.g., if strain exceeds recovery, add rest). Fine-tune diet based on energy levels.

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Month 3: Peak Performance and Maintenance

Focus: Fine-tune for lifelong sustainability. Emphasize biofeedback for personalized adjustments.

Dietary Protocols

• Primary Protocol: Advanced Autophagy-Focused Regimen.
  • Why: Combine keto, IF, and periodic extended fasts for maximal cellular cleanup.
  • Daily Structure: 20:4 IF; maintain keto macros but include one 36-hour fast biweekly.
  • Sample Meal Plan: Focus on nutrient-dense foods (e.g., add organ meats for micronutrients).

Supplement Stacks

• Focus: Cycle aggressively (3 days on, 4 days off) and monitor for peak effects.
• Stacks: Include all prior supplements; add Coenzyme Q10: 200 mg for mitochondrial support.

Exercise Routines

• Frequency: 5-6 days/week, with emphasis on recovery (e.g., add infrared sauna for enhanced benefits).
• Tracking: Use data to create a personalized routine (e.g., if HRV is low, prioritize recovery days).

Stress Resilience Techniques

• Daily Protocol: 20 minutes of integrated techniques (e.g., HRV + neurofeedback).
• Tracking: Aim for cognitive benchmarks (e.g., improved focus via app scores).

Weekly Schedule Overview

• Peak days: High-intensity training; maintenance days: Recovery and fasting.

Monitoring and Adjustments

• Monthly Review: Full biomarker panel; adjust the entire plan based on data for long-term use.

This plan is dynamic—use your wearables and journal to iterate. Remember, longevity is a marathon; track joy and sustainability too. Consult professionals regularly.