Advanced Longevity Plan (Biohacker)

3-MONTH PRECISION LONGEVITY BLUEPRINT
Goal: Add healthy years while maximizing concurrent physical output (strength, VO₂max, reaction time) and cognitive bandwidth (processing speed, memory, creativity).
Target user: Healthy, data-driven, non-pregnant, non-medicated adult. Always obtain physician sign-off; adjust to labs.

──────────────────────────────────── 0. PRE-CYCLE BASELINE (WEEK 0) • Blood: CBC, CMP, fasting insulin, HbA1c, thyroid panel, IGF-1, testosterone (total & free), estradiol, SHBG, hs-CRP, ApoB, Lp(a), omega-3 index, ferritin, vitamin D, B-vitamins, homocysteine, uric acid.
• Imaging: DEXA (body comp + visceral fat), coronary calcium score if >35 y.
• Function: VO₂max (PNOĒ or lab), 1-RM back-squat, 5-min y-balance test, DSST cognitive test, PVT 10-min.
• Wearables: Oura 3 (sleep & HRV), Apple Watch Ultra (ECG & training load), Dexcom G7 (2-week CGM), Continuous blood pressure (Omron HeartGuide).
• Microbiome: Viome or Ombre.

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1. MACRO-CALENDAR OVERVIEW MONTH 1 – “Priming & Sensitization”
   MONTH 2 – “Amplification & Adaptive Stress”
   MONTH 3 – “Consolidation & Renewal”

Each 28-day block is further broken into 4 micro-weeks (3 build + 1 deload). All numbers assume ~75 kg male; females scale BW% and cycle with luteal/follicular phases.

──────────────────────────────────── 2. NUTRITION PROTOCOLS 2.1 Framework
• Base: Cyclical ketogenic diet (CKD) 5 days SKD → 2 days targeted refeed (TKD).
• Protein: 1.6 g kg⁻¹ on lifting days, 1.2 g kg⁻¹ on rest.
• Fats: 65–70 % kcal; emphasize MUFAs + ω-3.
• Carbs: <30 g net on SKD; up to 150 g on refeed (evening only, resistant starch + honey).
• Fiber: 25–40 g from leafy greens, chia, artichoke.
• Polyphenols: 900 mg/day (EGCG, quercetin, pomegranate, cacao).
• Methylation support: 800 µg 5-MTHF, 1 mg methyl-B12, 50 mg P5P.

2.2 Monthly Fasting Schedule
Week 1: 16/8 daily TRF.
Week 2: 24-h fast (Mon) + 20/4 TRF other days.
Week 3: 36-h fast (Wed) + refeed.
Week 4: 3-day FMD (day 1 1,100 kcal 10 % P / 45 % F / 45 % C; days 2-3 725 kcal 9 % P / 44 % F / 47 % C) → exit with broccoli sprout smoothie (sulforaphane 20 mg) and kefir.

2.3 Meal Timing
• Caffeine only within 90 min waking.
• Final meal ≥3 h pre-bed; 20 g glycine + 400 mg magnesium L-threonate if hungry.
• Post-workout: 40 g whey isolate + 5 g creatine + 2 g HMB + 500 mg sodium bicarbonate.

2.4 Monthly Gut Reset
Days 26-28 of each month:
• Remove dairy, grains, eggs, nuts.
• Add 500 g steamed then chilled potatoes (RS3).
• Synbiotic: 100 B CFU multi-strain + 15 g GOS prebiotic nightly.

──────────────────────────────────── 3. SUPPLEMENT STACKS & CYCLING Morning “Longevity Core” (daily)
• NMN – 500 mg sublingual
• Trans-Resveratrol – 500 mg with 2 g C8 MCT + 5 g leucine for SIRT1 synergy
• Ca-AKG – 1 g
• Vitamin D3 – 5,000 IU if serum <50 ng ml⁻¹
• Vitamin K2 (MK-7) – 200 µg
• Omega-3 (EPA 1 g, DHA 500 mg) – 3 caps
• Lithium orotate – 1 mg elemental
• NAD+ cycle: 4 weeks on / 1 week off to avoid methyl-group drain.

Workout “Neuro-Performance” (training days only)
• Citicoline (CDP-choline) – 250 mg
• Acetyl-L-carnitine – 1 g
• Rhodiola rosea 3 % rosavin – 200 mg pre-AM workout
• Creatine monohydrate – 5 g daily (no cycling)
• Beta-alanine – 3.2 g split doses (paresthesia monitor)

Evening “Repair”
• Magnesium L-threonate – 400 mg
• Glycine – 3 g
• L-theanine – 200 mg
• Apigenin (chamomile extract) – 50 mg
Cycle: 5 days on / 2 off (weekend) to preserve GABA sensitivity.

Month-Specific Boosters
Month 1: Senolytics – Fisetin 1,500 mg for 2 consecutive days (Days 8-9).
Month 2: AMPK activator – Berberine 500 mg 2×/day with largest meals (only when CGM >110 mg/dL).
Month 3: Mitochondrial biogenesis – PQQ 20 mg + CoQ10 200 mg (ubiquinol).

──────────────────────────────────── 4. TRAINING PROGRAM 4.1 Weekly Template (deload on week 4)
Mon – Lower Strength (Squat, RDL, Bulgarian split, core)
Tue – HIIT Run (8×400 m @ 105 % vVO₂max) + 10 min cold plunge
Wed – Upper Push + Pull (Weighted dips, bench, pull-ups, rows) + mobility
Thu – Zone-2 Aerobic 60-90 min (HR 120-140) nasal breathing
Fri – Complexes / Power (KB clean-press-snatch) + 8 min HRV biofeedback
Sat – Fasted Hike (Zone-1) + 30 min infrared sauna 80 °C
Sun – OFF / breathwork / 30 min yin yoga

Progression: Add 2.5 % load or 1 rep per micro-week.
Cold exposure: 3 min @ 8 °C post-HIIT (increase norepinephrine 200-300 %).
Heat: 20 min sauna, 5 min cold, repeat 3 rounds (heat shock proteins + FOXO3).

4.2 Neuromuscular & Cognitive
• 5 min “neuro sprints” – dual-n-back on iPad while pedaling @ 50 % VO₂max.
• VR gaze-stability drills (Xponential+ app) 3× week for vestibular longevity.

──────────────────────────────────── 5. WEARABLE & DATA LOOP • Daily: Oura readiness ≥80 go hard, <70 deload.
• HRV CV target: <5 % week-to-week.
• CGM: Keep <140 mg/dL post-prandial, 1-h peak <30 mg/dL delta.
• Training load: Apple Watch Training Load < 5 % week-to-week spike.
• VO₂max reassess end of each month.
• Sleep debt: <5 h per 14-day rolling.

Automated rules (Zapier + Notion):
If Oura HRV drops >15 % vs 7-day mean → trigger “red day” (mobility + breathwork only).
If CGM >150 mg/dL 1-h post-lunch → auto-text to reduce next meal carbs 20 g.

──────────────────────────────────── 6. STRESS RESILIENCE & NEUROFEEDBACK Morning (5 min) – HRV Coherence: 5.5 bpm breathing via EliteHRV + EMWave Pro.
Afternoon (12 min) – Muse S neurofeedback “calm” protocol; reward threshold 80 % stillness.
Night (20 min) – HRV-guided yoga nidra with 0.1 Hz resonance breathing (6 bpm).
Weekly – 1 float tank 60 min (1,200 lbs Epsom salt).
Monthly – 1 guided psilocybin microdose (0.1 g dried, Fadiman protocol) paired with intention journaling; skip if contraindicated.

──────────────────────────────────── 7. SLEEP & CIRCADIAN OPTIMIZATION • 10 lux max light 2 h pre-bed (use red bulbs, blue-blockers).
• 5 min outside 10,000 lux within 30 min waking.
• 67 °F bedroom; ChiliPad OOLER 8-h schedule.
• 2 mg timed-release melatonin only on travel or circadian shift nights (max 1× week).
Track sleep staging nightly; target ≥90 min SWS & 90 min REM.

──────────────────────────────────── 8. PEPTIDE & HORMETIC MODULATORS (LEGAL/SCIENTIFIC) Month 2 only:
• BPC-157 (oral) 250 µg BID on GI-stress days.
• Epithalon 10 mg (10-day course, sub-Q before bed) – telomerase activation.
Month 3 only:
• MOTS-c 10 mg (5-day course) – mitochondrial peptide.

──────────────────────────────────── 9. MONTH-BY-MONTH ACTION GRANULARITY MONTH 1 – PRIMING
• Establish HRV baseline >45 ms rMSSD.
• Stabilize blood ketones 0.5-1.2 mmol/L every morning.
• Strength focus: 5×5 linear progression.
• Supplements: Core + fisetin senolytic.
• Protocol metric: ≥90 % adherence to nutrition, ≥7 h sleep average.

MONTH 2 – AMPLIFICATION
• Shift to undulating periodization (DUP).
• Weekly 36-h fast.
• Add berberine, AMPK focus.
• Sauna volume ↑ 50 %.
• Cognitive: 1 microdose day + 30 min dual-n-back weekly.
• VO₂max retest; goal +5 %.

MONTH 3 – CONSOLIDATION
• Drop volume 20 %, increase intensity peaks (cluster sets).
• 3-day FMD week 3.
• Focus on sleep debt zeroing; ≥15 % rise in deep sleep vs Month 1.
• Hormetic peptides (MOTS-c).
• Final labs + DEXA; adjust long-term plan.

──────────────────────────────────── 10. SAFETY & ETHICS • Contraindications: Genetic hemochromatosis (avoid iron), bipolar disorder (avoid microdose), low BP (caution berberine).
• Liver enzymes ALT/AST check after Month 2 if using berberine or peptides.
• Women: Adjust fasting and carbs to luteal phase (add 100 mg magnesium glycinate + 50 g extra carbs Days 21-28).
• Pregnancy planning: Pause NMN, resveratrol, caffeine >100 mg, all peptides.

──────────────────────────────────── 11. EXIT CRITERIA & LONG-TERM ROADMAP After 90 days:
• VO₂max ≥10 % ↑, HOMA-IR ↓ 20 %, HbA1c <5.2 %.
• Deep sleep ≥90 min, HRV ↑ 15 %.
• DEXA: +2 kg lean, -1 kg fat.
• Subjective: Morning energy 8/10, stress resilience 8/10.

If achieved → Enter 6-month “Epigenetic Optimization Cycle” (rapalog micro-dosing, plasma dilution trial, zone-5 cycling block).
If not → Root-cause labs (apoE, APOC3, thyroid antibodies, myostatin SNP) and personalize.

──────────────────────────────────── 12. QUICK REFERENCE CHEAT SHEET Morning stack: NMN 500 mg + Resveratrol 500 mg + C8 2 g + Ca-AKG 1 g.
Pre-workout: Citrulline 6 g + Beta-alanine 3.2 g + Rhodiola 200 mg.
Post-workout: Whey 40 g + Creatine 5 g + HMB 2 g + sodium bicarb 500 mg.
Night: Mag-L-threonate 400 mg + Glycine 3 g + Theanine 200 mg + Apigenin 50 mg.
Fast: 36 h every Month 2 & 3; FMD 3 days Month 1 & 3.
Train: Strength 3×, HIIT 1×, Zone-2 1×, Mobility 1×, Sauna 3×, Cold 3×.
Track: Oura HRV, CGM glucose, Training load, Sleep stages.
Breathe: 5.5 bpm morning, 6 bpm night.
Check: Labs at Day 0, 30, 90.

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