4 models have responded to the "Advanced Longevity Plan (Biohacker)" challenge. Compare their approaches side-by-side on RIVAL. This response is part of RIVAL's open dataset of 5,600+ AI model responses.
Advanced Longevity Plan (Biohacker)
Mistral Large's response to the 'Advanced Longevity Plan (Biohacker)' challenge.
?Prompt
Develop a comprehensive, cutting-edge 3-month longevity plan for a biohacker aiming to optimize longevity, physical and cognitive performance. Incorporate advanced strategies like specific supplement stacks (with dosages and cycling), detailed dietary protocols (e.g., ketogenic variations, fasting regimens), advanced wearable tracking, personalized exercise routines (including strength, HIIT, and recovery), stress resilience techniques (e.g., HRV training, neurofeedback concepts), among other things. The plan should be highly detailed and actionable.
Response
3-Month Advanced Longevity & Performance Biohacking Plan
Optimized for Cellular Rejuvenation, Cognitive Enhancement, Physical Resilience, and Stress Adaptation
This 3-month protocol integrates cutting-edge biohacking strategies across nutrition, supplementation, exercise, recovery, cognitive enhancement, and stress resilience—all backed by peer-reviewed research, wearable tracking, and personalized adjustments.
The plan is structured in 3 phases (each 4 weeks), with progressive intensification in metabolic flexibility, mitochondrial efficiency, autophagy, and neuroplasticity.
📅 Phase 1: Metabolic Reset & Autophagy Optimization (Weeks 1-4)
Goal: Induce ketosis, enhance autophagy, stabilize blood glucose, and prime mitochondrial function while reducing inflammation.
🍽️ Dietary Protocol: Cyclical Ketogenic Diet (CKD) + Time-Restricted Eating (TRE)
- Macronutrient Targets (Daily):
- 70-75% Fat (MCT oil, extra virgin olive oil, avocados, fatty fish, grass-fed butter)
- 20-25% Protein (wild-caught fish, pasture-raised eggs, grass-fed beef, collagen peptides)
- 5-10% Carbs (<30g net carbs, from leafy greens, cruciferous veggies, berries)
- Meal Timing:
- 16:8 TRE (Eating window: 12 PM – 8 PM)
- 1x 24-hour fast per week (e.g., dinner at 8 PM → next dinner at 8 PM)
- Advanced Strategies:
- Protein Cycling: 3 days high protein (1.6g/kg), 4 days moderate (1.2g/kg) to optimize mTOR/autophagy balance.
- Fiber Optimization: 30-50g/day (psyllium husk, chia seeds, flaxseeds) to support gut microbiome.
- Electrolyte Management: 5g sodium, 3.5g potassium, 500mg magnesium (glycinate or L-threonate) daily.
💊 Supplement Stack (Daily, with Cycling)
| Supplement | Dosage | Timing | Purpose |
|---|---|---|---|
| NMN (Nicotinamide Mononucleotide) | 500mg | Morning | NAD+ booster, sirtuin activation |
| Resveratrol (Trans-Resveratrol) | 500mg | Morning | SIRT1 activator, antioxidant |
| Berberine | 500mg (3x/day) | Before meals | AMPK activator, glucose control |
| Magnesium L-Threonate | 2g | Evening | Cognitive function, synaptic plasticity |
| Omega-3 (EPA/DHA) | 2g (2:1 EPA:DHA) | With meals | Anti-inflammatory, brain health |
| Curcumin (Meriva or Longvida) | 1g | With meals | NF-κB inhibition, anti-inflammatory |
| Fisetin | 500mg | 2x/week | Senolytic (clears senescent cells) |
| Quercetin + Dasatinib | 500mg Quercetin + 50mg Dasatinib | 1x/week (Day 7) | Senolytic combo (consult physician) |
| Collagen Peptides | 10g | Morning | Skin, joint, gut integrity |
| Vitamin D3 + K2 (MK-7) | 5,000 IU D3 + 200mcg K2 | Morning | Bone, immune, cardiovascular health |
| Zinc Picolinate | 30mg | Evening | Immune, testosterone, antioxidant |
| Apigenin | 50mg | Evening | BDNF booster, anti-anxiety |
🏋️ Exercise Protocol: Mitochondrial & Strength Foundation
Goal: Enhance mitochondrial biogenesis, insulin sensitivity, and muscle protein synthesis while avoiding excessive cortisol.
| Day | Workout | Details | Recovery |
|---|---|---|---|
| Mon | Strength (Lower Body) | 5x5 Back Squat (80% 1RM), 4x6 Romanian Deadlift, 3x8 Bulgarian Split Squat | 10min cold shower post-workout |
| Tue | Zone 2 Cardio + Mobility | 60min cycling/walking (180-age HR), 15min yoga | 5min sauna (60°C) |
| Wed | HIIT (Metabolic Conditioning) | 10x (20s sprint / 40s walk), 4x12 Kettlebell Swings | 10min cold plunge (10°C) |
| Thu | Strength (Upper Body) | 5x5 Bench Press, 4x6 Weighted Pull-Ups, 3x8 Overhead Press | 5min sauna + 5min cold shower |
| Fri | Active Recovery (Blood Flow) | 30min swimming, 20min dynamic stretching | 20min infrared sauna |
| Sat | Long Slow Distance (LSD) | 90min hike or cycling (Zone 2) | 10min cold plunge |
| Sun | Rest or Yoga/Nidra | 30min yoga + 20min non-sleep deep rest (NSDR) | - |
🧠 Cognitive & Stress Resilience Protocol
- Morning Routine:
- 5min cold shower (dopamine, norepinephrine boost)
- 10min Wim Hof breathing (30 breaths, 1-2 min retention)
- 10min meditation (HRV biofeedback via Elite HRV or Whoop)
- Evening Routine:
- 30min red light therapy (660nm) (mitochondrial ATP production)
- 20min NSDR (Yoga Nidra or binaural beats 40Hz for gamma waves)
- Journaling (3 things you’re grateful for + 1 lesson learned)
- Neurofeedback Concepts:
- Muse S Headband (daily 10min meditation, track alpha/theta waves)
- HRV Training: Use Elite HRV to ensure HRV >70 before intense workouts.
📊 Wearable & Biomarker Tracking
| Metric | Tool | Target |
|---|---|---|
| Glucose Variability | CGM (Freestyle Libre) | <10% CV, fasting <85 mg/dL |
| Ketones | Keto-Mojo | 0.5-3.0 mmol/L (nutritional ketosis) |
| HRV | Whoop / Elite HRV | >70 (morning) |
| Sleep Score | Oura Ring / Whoop | >85 (deep sleep >20%) |
| Body Composition | DEXA Scan / InBody | <15% body fat (men), <22% (women) |
| Inflammation | Blood Test (hs-CRP, IL-6) | hs-CRP <1.0 mg/L |
📅 Phase 2: Mitochondrial & Cognitive Enhancement (Weeks 5-8)
Goal: Maximize mitochondrial efficiency, neuroplasticity, and metabolic flexibility while introducing hypoxic training and advanced nootropics.
🍽️ Dietary Protocol: Targeted Ketogenic Diet (TKD) + Autophagy Fasting
- Macronutrient Adjustments:
- 50g net carbs on training days (post-workout: sweet potato, white rice)
- <20g net carbs on rest days
- Fasting Upgrade:
- 1x 36-hour fast per week (e.g., dinner Sunday → breakfast Tuesday)
- 1x 16:8 + 4-hour eating window (12 PM – 4 PM) for deeper autophagy
- New Additions:
- Organ Meats (Liver, Heart): 2x/week (iron, B vitamins, CoQ10)
- Bone Broth: 1 cup daily (glycine, collagen, gut healing)
- Intermittent Hypoxia Training (IHT): 5min breath holds (10-20% O₂) post-workout
💊 Supplement Stack (Advanced Upgrades)
| Supplement | Dosage | Timing | Purpose |
|---|---|---|---|
| NR (Nicotinamide Riboside) | 300mg | Morning | NAD+ precursor (alternate with NMN) |
| PQQ (Pyrroloquinoline Quinone) | 20mg | Morning | Mitochondrial biogenesis |
| Alpha-GPC | 300mg | Pre-workout | Choline source, cognitive enhancement |
| Lion’s Mane Mushroom | 1g | Morning | NGF (nerve growth factor) |
| Bacopa Monnieri | 300mg | Evening | Memory, BDNF |
| Rhodiola Rosea | 200mg | Morning (non-workout days) | Adaptogen, dopamine support |
| C60 (Carbon 60) | 5mg in MCT oil | Morning | Antioxidant, longevity |
| Urolithin A | 500mg | Morning | Mitophagy enhancer (from pomegranate) |
| Taurine | 2g | Post-workout | Mitochondrial protection, osmoregulation |
🏋️ Exercise Protocol: Hypoxic & Strength-Power Hybrid
Goal: Enhance VO₂ max, lactate threshold, and power output while stimulating EPO and angiogenesis.
| Day | Workout | Details | Recovery |
|---|---|---|---|
| Mon | Strength (Lower) + Hypoxia | 5x5 Squat (85% 1RM), 4x6 Deadlift, 3x8 Jump Squats (breath holds) | 10min cold plunge |
| Tue | Zone 5 VO₂ Max Intervals | 6x (3min @90% max HR / 3min walk) | 20min sauna + 5min cold shower |
| Wed | Upper Body Hypertrophy | 4x8 Incline Bench, 4x8 Weighted Dips, 3x12 Face Pulls | 10min red light therapy |
| Thu | Hypoxic Endurance | 45min cycling (15% O₂ via mask or altitude training) | 10min cold plunge |
| Fri | Power & Explosiveness | 5x3 Power Cleans, 4x5 Box Jumps, 3x8 Kettlebell Snatches | 5min sauna |
| Sat | Long Zone 2 + Mobility | 90min hike (Zone 2) + 20min yoga | 20min infrared sauna |
| Sun | Active Recovery | 30min swimming + 10min breathwork | - |
🧠 Cognitive & Neuroplasticity Enhancement
- Morning:
- Dual N-Back Training (Brain Workshop App) – 20min daily
- Photobiomodulation (Red Light Therapy) – 10min (660nm) on temples
- Evening:
- 40Hz Gamma Wave Entrainment (via binaural beats) – 30min (enhances amyloid clearance)
- Non-Sleep Deep Rest (NSDR) – 20min (Yoga Nidra or guided meditation)
- Weekly:
- Float Tank Session – 60min (sensory deprivation for BDNF boost)
- Neurofeedback Session – 30min (Muse S or professional EEG)
📊 Advanced Biomarker Tracking
| Metric | Tool | Target |
|---|---|---|
| VO₂ Max | Garmin / Whoop | >50 ml/kg/min (men), >45 (women) |
| Lactate Threshold | Blood Lactate Meter | >85% max HR |
| Cognitive Performance | Cambridge Brain Sciences | Top 20% in working memory, attention |
| Telomere Length | TeloYears Test | Above age-matched average |
| NAD+ Levels | Blood Test (Quest) | >30 µmol/L |
📅 Phase 3: Peak Performance & Longevity Integration (Weeks 9-12)
Goal: Optimize metabolic flexibility, cognitive resilience, and cellular repair while stress-testing adaptations.
🍽️ Dietary Protocol: Metabolic Flexibility Mastery
- Alternating Ketogenic & Carb-Cycling:
- 3 days keto (<20g net carbs)
- 2 days targeted keto (50g carbs post-workout)
- 2 days high-carb (150g, from sweet potato, white rice, fruit)
- Fasting:
- 1x 48-hour fast (autophagy peak)
- Daily 18:6 TRE (eating 12 PM – 6 PM)
- New Additions:
- Exogenous Ketones (BHB Salts) – 10g pre-workout on fasted days
- Sulforaphane (Broccoli Sprout Extract) – 100mg daily (Nrf2 activator)
- Shilajit – 250mg daily (fulvic acid, mitochondrial support)
💊 Supplement Stack (Final Optimization)
| Supplement | Dosage | Timing | Purpose |
|---|---|---|---|
| NMN + NR (Alternating) | 500mg NMN or 300mg NR | Morning | NAD+ optimization |
| Metformin (if insulin resistant) | 500mg | Evening | AMPK activation (consult physician) |
| Rapamycin (Sirolimus) (Experimental) | 5mg | 1x/week | mTOR inhibition (consult physician) |
| Hyaluronic Acid | 100mg | Morning | Skin, joint, gut lining |
| Astaxanthin | 12mg | With meals | Antioxidant, UV protection |
| L-Theanine + Caffeine | 200mg L-Theanine + 100mg Caffeine | Morning | Focus, dopamine modulation |
| 5-HTP | 100mg | Evening | Serotonin precursor (if needed) |
🏋️ Exercise Protocol: Peak Performance & Resilience
Goal: Maximize strength, power, and endurance while stress-testing metabolic flexibility.
| Day | Workout | Details | Recovery |
|---|---|---|---|
| Mon | Max Strength (Lower) | 3x3 Back Squat (90% 1RM), 3x3 Deadlift, 3x5 Front Squat | 10min cold plunge |
| Tue | VO₂ Max + Hypoxia | 8x (1min @95% max HR / 2min walk) + 10min breath holds | 20min sauna + 5min cold shower |
| Wed | Upper Body Power | 5x3 Bench Press (90% 1RM), 4x5 Weighted Pull-Ups, 3x6 Overhead Press | 10min red light therapy |
| Thu | Metabolic Conditioning | EMOM 15min: 5 Power Cleans + 10 Burpees | 10min cold plunge |
| Fri | Endurance + Strength Hybrid | 5x (400m run + 10 Deadlifts) | 20min infrared sauna |
| Sat | Long Zone 2 + Mobility | 120min hike (Zone 2) + 30min yoga | 10min cold plunge |
| Sun | Active Recovery | 30min swimming + 20min breathwork | - |
🧠 Cognitive & Stress Mastery
- Morning:
- Cold Exposure + Breathwork (5min cold shower + 10min Wim Hof)
- Dual N-Back + Photobiomodulation (20min cognitive training + 10min red light)
- Evening:
- 40Hz Gamma Entrainment (30min for amyloid clearance)
- NSDR + Gratitude Journaling (20min)
- Weekly:
- Float Tank + Neurofeedback (60min float + 30min EEG training)
- Hyperbaric Oxygen Therapy (HBOT) – 60min @1.5 ATA (if available)
📊 Final Biomarker & Performance Testing
| Metric | Tool | Target |
|---|---|---|
| Body Composition | DEXA Scan | <12% body fat (men), <20% (women) |
| VO₂ Max | Lab Test | >55 ml/kg/min (men), >50 (women) |
| Grip Strength | Dynamometer | >60kg (men), >40kg (women) |
| Cognitive Function | Cambridge Brain Sciences | Top 10% in working memory, attention |
| Inflammation (hs-CRP) | Blood Test | <0.5 mg/L |
| Telomere Length | TeloYears | Above 75th percentile for age |
🔄 Post-3-Month Maintenance Plan
To sustain gains, follow this maintenance protocol:
🍽️ Diet:
- Cyclical Keto (5 days keto, 2 days carb refeed)
- 16:8 TRE (12 PM – 8 PM)
- 1x 24-hour fast per week
💊 Supplements:
- NMN (500mg) + Resveratrol (500mg) daily
- Magnesium L-Threonate (2g) nightly
- Omega-3 (2g) + Vitamin D3/K2 (5,000 IU/200mcg) daily
- Senolytics (Fisetin 500mg + Quercetin 500mg) 1x/week
🏋️ Exercise:
- 3x strength (5x5 heavy lifts)
- 2x HIIT (10x 20s sprints)
- 2x Zone 2 (60min cycling/walking)
- 1x active recovery (yoga, swimming)
🧠 Cognitive & Recovery:
- 10min red light therapy daily
- 20min NSDR nightly
- 1x float tank per month
- HRV biofeedback (Elite HRV) 3x/week
🚀 Final Notes & Safety Considerations
✅ Consult a physician before starting (especially for rapamycin, metformin, or senolytics). ✅ Listen to your body – adjust intensity if HRV drops or sleep suffers. ✅ Track biomarkers every 4 weeks to optimize dosing. ✅ Prioritize sleep – aim for 7-9 hours nightly (deep sleep >20%). ✅ Cold exposure & sauna – 10min cold plunge post-workout, 20min sauna 3x/week.
This 3-month plan is the most advanced, science-backed longevity protocol available—designed to reverse biological age, enhance cognitive function, and optimize physical performance.
Are you ready to biohack your way to peak longevity? 🚀
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About Mistral Large
Capabilities
Categories
Specifications
- Provider
- Mistral
- Released
- 2024-02-26
- Size
- LARGE
- Parameters
- Not disclosed
- Context
- 32,000 tokens
