< The plan should be highly detailed and actionable."

Advanced 3-Month Biohacker Longevity Optimization Protocol

Executive Summary

This comprehensive protocol integrates cutting-edge longevity science, performance optimization, and biohacking strategies into a systematic 3-month program. The plan emphasizes measurable outcomes, safety, and progressive adaptation.

Month 1: Foundation & Baseline Establishment

Week 1-2: Assessment & Preparation

Baseline Testing

• Comprehensive Blood Panel:

  • Complete metabolic panel, lipid profile, HbA1c, fasting insulin
  • Hormones: Testosterone, estradiol, DHEA-S, cortisol (4-point), TSH, Free T3/T4
  • Inflammatory markers: hs-CRP, homocysteine, fibrinogen
  • Nutrients: Vitamin D, B12, folate, magnesium RBC, zinc, copper
  • Advanced: ApoB, Lp(a), omega-3 index, oxidized LDL

• Physical Assessment:_

  • DEXA scan for body composition
  • VO2 max testing
  • Grip strength measurement
  • Heart Rate Variability baseline (morning readings for 7 days)

• Cognitive Baseline:_

  • Cambridge Brain Sciences assessment
  • Reaction time testing (Human Benchmark)
  • Sleep quality assessment (Pittsburgh Sleep Quality Index)

Dietary Protocol - Month 1

Weeks 1-2: Metabolic Reset

• Modified Ketogenic Diet (70% fat, 20% protein, 10% carbs)
• Daily caloric intake: Calculate TDEE × 0.9 for mild deficit
• Meal timing: 16:8 intermittent fasting window (12pm-8pm feeding)

Sample Daily Menu:

• First Meal (12pm):

  • 3 eggs cooked in 1 tbsp grass-fed butter
  • 1/2 avocado
  • 2 cups mixed greens with 2 tbsp olive oil
  • 4 oz wild-caught salmon

• Second Meal (4pm):

  • 6 oz grass-fed beef
  • 2 cups steamed broccoli with 1 tbsp MCT oil
  • 1 oz macadamia nuts

• Final Meal (7pm):

  • 4 oz chicken thigh
  • Cauliflower rice with coconut oil
  • Green salad with pumpkin seeds

Weeks 3-4: Fasting Integration

• Tuesday/Thursday: 24-hour fasts (dinner to dinner)
• Continue 16:8 on other days
• Sunday: Refeed day with 150% normal calories, 30% carbs

Supplement Stack - Month 1

Morning (with first meal):

• NAD+ Support Complex:

  • NMN: 500mg
  • Resveratrol: 500mg (with fat source)
  • Quercetin: 500mg
  • Fisetin: 100mg

• Mitochondrial Support:

  • CoQ10 (ubiquinol): 200mg
  • PQQ: 20mg
  • Alpha-lipoic acid: 300mg

• Essential Stack:

  • Vitamin D3: 5000 IU (adjust based on blood levels)
  • Vitamin K2 (MK-7): 200mcg
  • Magnesium glycinate: 400mg
  • Zinc picolinate: 15mg

Afternoon:

• Cognitive Enhancement:
  • Lion's Mane: 1000mg
  • Bacopa Monnieri: 300mg (standardized to 50% bacosides)
  • Rhodiola Rosea: 200mg (3% rosavins, 1% salidroside)

Evening (2 hours before bed):

• Sleep & Recovery:
  • Magnesium threonate: 2000mg
  • L-theanine: 200mg
  • Ashwagandha (KSM-66): 600mg
  • Glycine: 3g

Exercise Protocol - Month 1

Monday/Thursday: Strength Training (45-60 minutes)

Workout A:

• Barbell squat: 4×6-8 @ 80% 1RM
• Romanian deadlift: 3×8-10
• Walking lunges: 3×12 each leg
• Leg curls: 3×12-15
• Calf raises: 4×15-20

Workout B:

• Bench press: 4×6-8 @ 80% 1RM
• Bent-over row: 4×8-10
• Overhead press: 3×8-10
• Pull-ups: 3×max reps
• Face pulls: 3×15-20

Tuesday/Friday: HIIT (20 minutes)

• 5-minute warm-up
• 8 rounds: 20 seconds all-out, 40 seconds recovery
• 5-minute cool-down
• Track: Power output, heart rate recovery

Wednesday: Zone 2 Cardio (45-60 minutes)

• Target: 180 - age = max heart rate
• Activities: Brisk walking, cycling, swimming
• Nasal breathing only

Saturday: Active Recovery

• 30 minutes yoga or mobility work
• 20 minutes sauna (if available)
• Cold exposure: 3 minutes cold shower

Sunday: Rest

Stress Resilience & Recovery - Month 1

Daily Practices:

• Morning HRV Training (10 minutes):

  • Use HRV biofeedback device (WHOOP, Oura, or dedicated HRV sensor)
  • Resonance breathing: 5 seconds in, 5 seconds out
  • Target: Increase HRV by 10% over baseline

• Meditation (20 minutes):

  • Week 1-2: Guided mindfulness (Headspace/Calm)
  • Week 3-4: Transition to unguided practice

• Evening Routine:

  • Blue light blocking glasses 2 hours before bed
  • Room temperature: 65-68°F
  • Complete darkness (blackout curtains)
  • White noise or silence

Tracking & Metrics - Month 1

Wearables Setup:

• Primary: WHOOP 4.0 or Oura Ring Gen 3
• Secondary: Continuous Glucose Monitor (Levels or Supersapiens)
• Optional: Eight Sleep pod for sleep optimization

Daily Tracking:

• Morning: HRV, resting heart rate, body temperature
• Throughout day: Steps (target 10,000), glucose responses
• Evening: Sleep readiness score
• Weekly: Body weight, body measurements, photos

Month 2: Optimization & Advanced Protocols

Dietary Protocol - Month 2

Weeks 5-6: Cyclical Ketogenic Diet

• Monday-Friday: Strict keto (<20g carbs)
• Saturday: Carb refeed (2g/kg body weight from sweet potatoes, white rice)
• Sunday: Modified keto (50g carbs)

Weeks 7-8: Extended Fasting

• One 48-hour fast (Wednesday dinner to Friday dinner)
• Preparation: Increase electrolytes 2 days prior
• During fast:
  • Snake juice: 2L water, 1 tsp pink salt, 1 tsp potassium chloride
  • Black coffee, green tea allowed
  • Light walking only

Supplement Stack - Month 2 (Additions/Modifications)

Cycling Protocol:

• Week 5-6: Add Sulforaphane (from broccoli sprouts): 40mg daily
• Week 7-8: Cycle off NAD+ precursors, maintain others

New Additions:

• Methylene Blue (pharmaceutical grade): 0.5mg/kg body weight, 2x/week
• C60 in olive oil: 5ml daily
• Spermidine: 5mg daily
• Rapamycin (prescription required): 5mg once weekly (consult physician)

Exercise Protocol - Month 2

Progressive Overload:

• Increase weights by 5-10% from Month 1
• Add blood flow restriction training to last set of each exercise

Monday/Thursday: Modified Strength

• Incorporate cluster sets for main lifts
• Add 2 minutes rest-pause sets for accessories

Tuesday/Friday: Advanced HIIT

• Wingate protocol: 4×30 seconds all-out, 4 minutes recovery
• Track peak power and fatigue index

Wednesday: MAF Training

• 60-75 minutes at MAF heart rate (180 - age)
• Monthly MAF test to track improvement

Saturday: Contrast Training

• 20 minutes sauna
• 3-5 minutes ice bath
• Repeat 3 rounds
• End with cold

Advanced Biohacking - Month 2

Photobiomodulation:

• Red light therapy: 10 minutes morning, 10 minutes evening
• Target areas: Face, chest, back
• Wavelengths: 660nm and 850nm

Neurofeedback Training:

• 2 sessions/week using Muse or similar device
• Focus on increasing alpha waves and gamma bursts

Grounding/Earthing:

• 20 minutes barefoot contact with earth daily
• Track inflammatory markers

Cognitive Enhancement Protocol - Month 2

Nootropic Cycling:

Week 5-6:

• Modafinil: 100mg, 2x/week (Tuesday/Friday)
• Noopept: 10mg sublingual, daily
• Aniracetam: 750mg with fat source, 2x daily

Week 7-8:

• Phenylpiracetam: 100mg, 3x/week
• L-theanine + Caffeine: 200mg/100mg for focus sessions
• Nicotinamide riboside: 300mg daily

Month 3: Advanced Integration & Personalization

Dietary Protocol - Month 3

Weeks 9-10: Protein Cycling

• Monday/Wednesday/Friday: High protein (1.5g/kg)
• Tuesday/Thursday: Low protein (0.5g/kg) - activate autophagy
• Weekend: Moderate protein (1g/kg)

Weeks 11-12: Personalized Approach

• Based on CGM data, create personalized meal timing
• Implement targeted supplementation based on Month 2 blood work

Exercise Protocol - Month 3

Periodization:

• Week 9-10: Deload (70% intensity)
• Week 11-12: Peak phase (test new 1RMs)

Advanced Techniques:

• German Volume Training for hypertrophy
• Velocity-based training for power
• Heart rate variability-guided training intensity

Longevity Interventions - Month 3

Hormetic Stressors:

• Hypoxic training: 3x/week breath holds
• Heat shock: 4x/week sauna at 180°F for 20 minutes
• Cold shock: Daily cold showers progressing to ice baths

Advanced Supplementation:

• Plasmalogens: 1mg daily
• Urolithin A: 500mg daily
• Ergothioneine: 5mg daily
• Beta-alanine: 3g daily for muscle endurance

Sleep Optimization - Month 3

Advanced Protocol:

• Temperature regulation: ChiliPad set to drop 2°F every 2 hours
• Pink noise during deep sleep phases
• Morning light exposure: 10,000 lux for 30 minutes upon waking
• Evening: Red light only after sunset

Final Assessment & Future Planning

Week 12 Testing:

• Repeat all baseline blood work
• DEXA scan comparison
• VO2 max retest
• Cognitive assessments
• Compile 3-month data trends

Data Analysis:

• Identify top 20% interventions by impact
• Create personalized long-term protocol
• Plan quarterly testing schedule

Safety Considerations & Disclaimers

1. Medical Supervision: Consult healthcare providers before starting, especially for prescription items
2. Individual Variation: Adjust protocols based on personal response
3. Quality Sources: Use third-party tested supplements only
4. Gradual Implementation: Don't start everything at once
5. Listen to Your Body: Stop any intervention causing adverse effects

Expected Outcomes

Based on scientific literature and anecdotal reports:

• 10-20% improvement in VO2 max
• 15-25% increase in HRV
• 5-10% reduction in body fat (if starting >15%)
• 20-30% improvement in cognitive test scores
• Significant improvements in energy and recovery
• Optimized bloodwork markers

Monthly Investment Estimate

• Supplements: $400-600
• Testing: $500-1000 (Month 1 & 3)
• Devices/Wearables: $500-1500 (one-time)
• Food: $600-800 (quality sources)
• Professional services: $200-500 (optional)

This protocol represents the cutting edge of longevity science and biohacking. Individual results will vary, and continuous optimization based on personal data is essential for long-term success. joaquintournier@Joaquins-MacBook-Pro Rival %