Advanced Longevity Plan (Biohacker)

This comprehensive 3-month longevity plan is designed to push your physiological systems to their adaptive ceiling while ensuring sustainability. It utilizes the principles of Mitochondrial Biogenesis, Nervous System Regulation, and Nutrient Timing.

Disclaimer: This plan involves advanced biohacking protocols. Always consult with a physician before starting, especially regarding supplements and heavy exercise.

---

Phase 1: The Reset & Adaptation (Weeks 1-4)

Objective: Establish circadian rhythms, reduce systemic inflammation, and prepare the nervous system for higher intensity.

1. The Nutritional Protocol: "Targeted Fasting & Polyphenol Loading"

• Protocol: Targeted Fasting (16:8 + 1hr Carb Window).
  • 12:00 PM – 8:00 PM: Eating window (High nutrient density).
  • 8:00 PM – 12:00 PM: Overnight fast (allows autophagy).
  • 1 Hour before workouts: Consume 25-50g of fast-acting carbs (white rice, dextrose) to spare muscle glycogen and fuel the mitochondria without spiking insulin too high.
• Dietary Focus: Low PUFA, High Polyphenol.
  • Eliminate vegetable oils (soybean, corn, canola) and processed seed oils.
  • Focus on Wild-Caught Salmon (Omega-3), Avocados, Walnuts, and Berries.
  • Superfood Add-in: 1 tbsp of MCT Oil (caprylic acid) daily for ketone production during fasts.

2. The Supplement Stack (The Foundation)

• Nootropic/Cognitive:
  • Lion’s Mane Mushroom (500mg 2x/day): Neurogenesis support.
  • Phosphatidylserine (100mg 2x/day): Cortisol management and memory.
• Longevity/Mitochondria:
  • Coenzyme Q10 (Ubiquinol) (200mg daily): Mitochondrial electron transport.
  • Vitamin D3 + K2 (5000 IU / 100mcg): Hormonal optimization.
  • Magnesium Glycinate (400mg): Sleep and parasympathetic tone.
• Detoxification:
  • N-Acetylcysteine (NAC) (600mg 2x/day): Glutathione precursor and lung support.

3. The Exercise Protocol

• Strength (3x/week): Full-body compound movements. Focus on eccentric control (slow lowering).
• Zone 2 Cardio (4x/week): 45 mins brisk walk, cycling, or swimming where you can hold a conversation but are breathing harder than normal. This builds mitochondrial density.
• Recovery: Cold plunge (2 mins) immediately post-workout.

---

Phase 2: The Optimization & Intensity (Weeks 5-8)

Objective: Maximize mitochondrial efficiency, spike NAD+ levels, and train the nervous system to handle stress.

1. The Supplement Stack (The Upgrade)

• NAD+ Boosters (Cycle these):
  • Nicotinamide Riboside (NR) or NMN (500mg 2x/day) for 4 weeks, then pause.
• Mitochondrial Biogenesis:
  • PQQ (Pyrroloquinoline Quinone) (20mg daily): Co-factors for mitochondrial growth.
• Inflammation Control:
  • Curcumin Phytosome (500mg 2x/day): High absorption anti-inflammatory.

2. The Nutritional Protocol: "Cyclical Ketosis"

• Protocol: Cyclical Ketogenic Diet (CKD).
  • Fasting Days (1-2x/week): OMAD (One Meal A Day) to maximize autophagy.
  • Carb Re-feed Days: High carbohydrate intake (6g carbs/kg body weight) specifically post-workout to spike insulin and drive muscle glycogen.
• Hydration: Add Sodium Citrate (1/4 tsp) to water to buffer lactic acid and improve endurance.

3. The Exercise Protocol: "The Big 3"

• Strength (4x/week): Hypertrophy/Strength hybrid. Focus on 5x5 or 5/3/1 style lifting.
• HIIT (2x/week): 20 mins total time.
  • 10 mins: 30s sprint / 30s rest.
  • 10 mins: 60s sprint / 60s rest.
• Neuro-Link: Perform 5 minutes of "Brain Loading" (complex cognitive puzzles) immediately before lifting weights to synchronize mind-muscle connection.

---

Phase 3: The Peak & Consolidation (Weeks 9-12)

Objective: Test peak performance, consolidate gains, and fine-tune hormonal baselines.

1. The Supplement Stack (The Polish)

• Stress Adaptation:
  • Ashwagandha KSM-66 (600mg 1x/day): Reduces cortisol by 30% in studies.
• Joint/Ligament Health:
  • Collagen Peptides (20g daily): Crucial for tendon density.

2. The Nutritional Protocol: "Protein Cycling"

• Protocol: High protein on training days (2g/kg), Moderate protein on rest days (1.2g/kg).
• Fasting: Extend the overnight fast to 18 hours on non-training days.

3. The Exercise Protocol: "Peaking & Deload"

• Strength (5x/week): Intensity technique focus (Drop sets, rest-pause).
• Active Recovery: 20 mins of mobility work + 10 mins of meditation daily.
• Cold Exposure: Progressive overload. Increase duration to 5-10 minutes.

---

Advanced Recovery & Stress Resilience

Wearable Tracking & HRV Biofeedback

You must track Heart Rate Variability (HRV).

• The Rule: If your HRV is more than 10% below your personal baseline, do not do HIIT or heavy lifting. Perform Zone 2 cardio or complete rest.
• Technology: Use Oura Ring or WHOOP.
  • Sleep Score > 80: Proceed with high intensity.
  • Sleep Score < 75: Prioritize sleep hygiene and reduce sodium.

Morning Routine (The "Biohack" Clock)

1. 06:00 AM: Wake up, expose eyes to sunlight (10 mins) to set circadian rhythm.
2. 06:15 AM: 10 minutes of Wim Hof Breathing (3 rounds of 30 deep breaths, holding last breath, hyperventilating). Follow with a 1-minute cold water hold.
3. 06:30 AM: Black coffee or green tea (L-Theanine) to sharpen focus.
4. 06:45 AM: Magnesium Glycinate and Omega-3s.
5. 07:00 AM: Workout (if planned for morning) or Cognitive work.

Neurofeedback Concepts

• Heart Rate Coherence (HRC): Use the HeartMath app or similar. Sync your breath to your heart rate. Inhale 5s, hold 5s, exhale 5s, hold 5s. This lowers cortisol and improves cognitive performance within 5 minutes.
• Sensory Deprivation: Once a week, spend 60 minutes in a quiet, dimly lit room with no screens to recalibrate dopamine receptors.

Summary of Key Metrics to Track

To verify the success of this plan, you must measure:

1. VO2 Max (Wearable estimate).
2. Body Composition (DEXA scan at start and end of Month 3).
3. Blood Biomarkers (HbA1c, LDL/HDL, Vitamin D, Inflammatory markers like CRP).
4. Subjective Energy Levels (RPE - Rate of Perceived Exertion should drop over time for the same workload).